Trifluridine- and tipiracil-induced DPD inhibition mimicking DPD deficiency: a case report

Fluoropyrimidines, including 5-fluorouracil (5-FU) and its derivatives, remain the standard first-line treatment for metastatic colorectal cancer (mCRC). In recent years, trifluridine/tipiracil (TAS-102), an orally administered combination drug, has become a common third-line therapy for mCRC and co...

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Bibliographic Details
Main Authors: Antonin Schmitt, Baptiste Bouillet, Bernard Royer, François Ghinringhelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1591120/full
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