The Association of the GABRP Polymorphisms with Systemic Lupus Erythematosus
Gamma-aminobutyric acid receptor subunit pi (GABRP) is involved in inhibitory synaptic transmission in the central nervous system. This gene encodes multisubunit chloride channels and is also expressed in numerous nonneuronal tissues such as the uterus and the ovaries. This study was aimed to valida...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/602154 |
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| author | Hun-Soo Kim Eun-Heui Jin Ji-Su Mo Hyeok Shim Shin-Seok Lee Soo-Cheon Chae |
| author_facet | Hun-Soo Kim Eun-Heui Jin Ji-Su Mo Hyeok Shim Shin-Seok Lee Soo-Cheon Chae |
| author_sort | Hun-Soo Kim |
| collection | DOAJ |
| description | Gamma-aminobutyric acid receptor subunit pi (GABRP) is involved in inhibitory synaptic transmission in the central nervous system. This gene encodes multisubunit chloride channels and is also expressed in numerous nonneuronal tissues such as the uterus and the ovaries. This study was aimed to validate whether the polymorphisms in the GABRP gene are associated with the susceptibility to systematic lupus erythematosus (SLE). The genotype frequencies of the rs929763, rs732157, and rs3805455 of the GABRP gene in SLE patients were significantly different from those of the control group (P<0.0001, P=0.05 and 0.002, resp.). Additional analysis showed that the genotype of the rs929763 and rs3805455 of the GABRP gene were also significantly associated with female SLE patients (P<0.0001, P=0.005, resp.). Two haplotype frequencies including a major haplotype of GABRP SNPs were more significantly different between the SLE patients and the healthy controls (P=0.038 and 4.2E-24, resp.). These results suggest that the polymorphisms in the GABRP gene might be associated with the susceptibility to SLE and the haplotype of GABRP SNPs is useful genetic marker for SLE. |
| format | Article |
| id | doaj-art-3f85dfcdb0a64c668026439109ed3bd8 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-3f85dfcdb0a64c668026439109ed3bd82025-02-03T01:26:44ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/602154602154The Association of the GABRP Polymorphisms with Systemic Lupus ErythematosusHun-Soo Kim0Eun-Heui Jin1Ji-Su Mo2Hyeok Shim3Shin-Seok Lee4Soo-Cheon Chae5Department of Pathology, School of Medicine, Wonkwang University, Iksan, Chonbuk 570-749, Republic of KoreaDepartment of Pathology, School of Medicine, Wonkwang University, Iksan, Chonbuk 570-749, Republic of KoreaDepartment of Pathology, School of Medicine, Wonkwang University, Iksan, Chonbuk 570-749, Republic of KoreaDepartment of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Chonbuk 570-749, Republic of KoreaDivision of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju 501-746, Republic of KoreaDepartment of Pathology, School of Medicine, Wonkwang University, Iksan, Chonbuk 570-749, Republic of KoreaGamma-aminobutyric acid receptor subunit pi (GABRP) is involved in inhibitory synaptic transmission in the central nervous system. This gene encodes multisubunit chloride channels and is also expressed in numerous nonneuronal tissues such as the uterus and the ovaries. This study was aimed to validate whether the polymorphisms in the GABRP gene are associated with the susceptibility to systematic lupus erythematosus (SLE). The genotype frequencies of the rs929763, rs732157, and rs3805455 of the GABRP gene in SLE patients were significantly different from those of the control group (P<0.0001, P=0.05 and 0.002, resp.). Additional analysis showed that the genotype of the rs929763 and rs3805455 of the GABRP gene were also significantly associated with female SLE patients (P<0.0001, P=0.005, resp.). Two haplotype frequencies including a major haplotype of GABRP SNPs were more significantly different between the SLE patients and the healthy controls (P=0.038 and 4.2E-24, resp.). These results suggest that the polymorphisms in the GABRP gene might be associated with the susceptibility to SLE and the haplotype of GABRP SNPs is useful genetic marker for SLE.http://dx.doi.org/10.1155/2015/602154 |
| spellingShingle | Hun-Soo Kim Eun-Heui Jin Ji-Su Mo Hyeok Shim Shin-Seok Lee Soo-Cheon Chae The Association of the GABRP Polymorphisms with Systemic Lupus Erythematosus Journal of Immunology Research |
| title | The Association of the GABRP Polymorphisms with Systemic Lupus Erythematosus |
| title_full | The Association of the GABRP Polymorphisms with Systemic Lupus Erythematosus |
| title_fullStr | The Association of the GABRP Polymorphisms with Systemic Lupus Erythematosus |
| title_full_unstemmed | The Association of the GABRP Polymorphisms with Systemic Lupus Erythematosus |
| title_short | The Association of the GABRP Polymorphisms with Systemic Lupus Erythematosus |
| title_sort | association of the gabrp polymorphisms with systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2015/602154 |
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