Serum hydroxycotinine was associated with chronic kidney disease (CKD): a cross-sectional study based on NHANES
Objective Smoking has been suggested as a modifiable and cardiovascular risk factor for chronic kidney disease (CKD). Although long-term smoking has been associated with CKD, the potential relationship between its metabolite hydroxycotinine and CKD has not been clarified.Methods A total of 8,544 par...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2356024 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591089121361920 |
|---|---|
| author | Meng’en Zhu Zhimin Bi Yaoling Wang Wei Li |
| author_facet | Meng’en Zhu Zhimin Bi Yaoling Wang Wei Li |
| author_sort | Meng’en Zhu |
| collection | DOAJ |
| description | Objective Smoking has been suggested as a modifiable and cardiovascular risk factor for chronic kidney disease (CKD). Although long-term smoking has been associated with CKD, the potential relationship between its metabolite hydroxycotinine and CKD has not been clarified.Methods A total of 8,544 participants aged 20 years and above from the National Health and Nutrition Examination Survey (NHANES) 2017 - March 2020 were enrolled in our study. CKD was defined by estimated glomerular filtration rate (eGFR) < 60 mL/(min*1.73 m2). Serum hydroxycotinine was measured by an isotope-dilution high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometric (ID HPLC-APCI MS/MS) method with a lower limit of detections (LLOD) at 0.015 ng/mL. The non-linear relationship was explored with restricted cubic splines (RCS). Pearson’s correlation coefficient and a multivariate logistic regression model were used for correlation analysis.Results Serum hydroxycotinine and eGFR were negatively correlated in both non-CKD group (r= −0.05, p < 0.001) and CKD group (r= −0.04, p < 0.001). After serum hydoxycotinine dichotominzed with LLOD, serum hydroxycotinine ≥ 0.015 ng/mL was negatively correlated with eGFR not only in non-CKD group (r = −0.05, p < 0.001) but also in CKD group (r = −0.09, p < 0.001). After adjusting for comprehensive confounders, results from the multivariate logistic regression analysis showed that participants with serum hydroxycotinine ≥ 0.015 ng/mL had increased odds of CKD (OR = 1.505, p < 0.001).Conclusions Serum hydroxycotinine might be positively associated with CKD. Further study is warranted to find the right concentration of hydroxycotinine to measure the CKD. |
| format | Article |
| id | doaj-art-3f81504fbc894a5ba532c3d4ff2862e3 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-3f81504fbc894a5ba532c3d4ff2862e32025-01-23T04:17:47ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2356024Serum hydroxycotinine was associated with chronic kidney disease (CKD): a cross-sectional study based on NHANESMeng’en Zhu0Zhimin Bi1Yaoling Wang2Wei Li3Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Nephrology, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan University, Wuhan, P.R. ChinaDepartment of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaObjective Smoking has been suggested as a modifiable and cardiovascular risk factor for chronic kidney disease (CKD). Although long-term smoking has been associated with CKD, the potential relationship between its metabolite hydroxycotinine and CKD has not been clarified.Methods A total of 8,544 participants aged 20 years and above from the National Health and Nutrition Examination Survey (NHANES) 2017 - March 2020 were enrolled in our study. CKD was defined by estimated glomerular filtration rate (eGFR) < 60 mL/(min*1.73 m2). Serum hydroxycotinine was measured by an isotope-dilution high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometric (ID HPLC-APCI MS/MS) method with a lower limit of detections (LLOD) at 0.015 ng/mL. The non-linear relationship was explored with restricted cubic splines (RCS). Pearson’s correlation coefficient and a multivariate logistic regression model were used for correlation analysis.Results Serum hydroxycotinine and eGFR were negatively correlated in both non-CKD group (r= −0.05, p < 0.001) and CKD group (r= −0.04, p < 0.001). After serum hydoxycotinine dichotominzed with LLOD, serum hydroxycotinine ≥ 0.015 ng/mL was negatively correlated with eGFR not only in non-CKD group (r = −0.05, p < 0.001) but also in CKD group (r = −0.09, p < 0.001). After adjusting for comprehensive confounders, results from the multivariate logistic regression analysis showed that participants with serum hydroxycotinine ≥ 0.015 ng/mL had increased odds of CKD (OR = 1.505, p < 0.001).Conclusions Serum hydroxycotinine might be positively associated with CKD. Further study is warranted to find the right concentration of hydroxycotinine to measure the CKD.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2356024NHANESCKDeGFRsmokeserum hydroxycotinine |
| spellingShingle | Meng’en Zhu Zhimin Bi Yaoling Wang Wei Li Serum hydroxycotinine was associated with chronic kidney disease (CKD): a cross-sectional study based on NHANES Renal Failure NHANES CKD eGFR smoke serum hydroxycotinine |
| title | Serum hydroxycotinine was associated with chronic kidney disease (CKD): a cross-sectional study based on NHANES |
| title_full | Serum hydroxycotinine was associated with chronic kidney disease (CKD): a cross-sectional study based on NHANES |
| title_fullStr | Serum hydroxycotinine was associated with chronic kidney disease (CKD): a cross-sectional study based on NHANES |
| title_full_unstemmed | Serum hydroxycotinine was associated with chronic kidney disease (CKD): a cross-sectional study based on NHANES |
| title_short | Serum hydroxycotinine was associated with chronic kidney disease (CKD): a cross-sectional study based on NHANES |
| title_sort | serum hydroxycotinine was associated with chronic kidney disease ckd a cross sectional study based on nhanes |
| topic | NHANES CKD eGFR smoke serum hydroxycotinine |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2356024 |
| work_keys_str_mv | AT mengenzhu serumhydroxycotininewasassociatedwithchronickidneydiseaseckdacrosssectionalstudybasedonnhanes AT zhiminbi serumhydroxycotininewasassociatedwithchronickidneydiseaseckdacrosssectionalstudybasedonnhanes AT yaolingwang serumhydroxycotininewasassociatedwithchronickidneydiseaseckdacrosssectionalstudybasedonnhanes AT weili serumhydroxycotininewasassociatedwithchronickidneydiseaseckdacrosssectionalstudybasedonnhanes |