Integrating QSAR modelling with reinforcement learning for Syk inhibitor discovery

Integrating QSAR modelling with reinforcement learning for Syk inhibitor discovery

Abstract Spleen tyrosine kinase (Syk) is a crucial mediator of inflammatory processes and a promising therapeutic target for the management of autoimmune disorders, such as immune thrombocytopenia. While several Syk inhibitors are known to date, their efficacy and safety profiles remain suboptimal,...

Full description

Saved in:
Bibliographic Details
Main Authors: Maria Zavadskaya, Anastasia Orlova, Andrei Dmitrenko, Vladimir Vinogradov
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Cheminformatics
Subjects:
Generative design
Drug discovery
QSAR
Machine learning
Syk inhibitors
Reinforcement learning
Online Access:https://doi.org/10.1186/s13321-025-00998-2
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items