Inflammatory response to strenuous muscular exercise in man
Based on the humoral and cellular changes occurring during strenuous muscular work in humans, the concept of inflammatory response to exercise (IRE) is developed. The main indices of IRE consist of signs of an acute phase response, leucocytosis and leucocyte activation, release of inflammatory media...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1993-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935193000468 |
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| author | G. Camus G. Deby-Dupont C. Deby A. Juchmès-Ferir J. Pincemail M. Lamy |
| author_facet | G. Camus G. Deby-Dupont C. Deby A. Juchmès-Ferir J. Pincemail M. Lamy |
| author_sort | G. Camus |
| collection | DOAJ |
| description | Based on the humoral and cellular changes occurring during strenuous muscular work in humans, the concept of inflammatory response to exercise (IRE) is developed. The main indices of IRE consist of signs of an acute phase response, leucocytosis and leucocyte activation, release of inflammatory mediators, tissue damage and cellular infiltrates, production of free radicals, activation of complement, and coagulation and fibrinolytic pathways. Depending on exercise intensity and duration, it seems likely that muscle and/or associated connective tissue damage, contact system activation due to shear stress on endothelium and endotoxaemia could be the triggering mechanisms of IRE. Although this phenomenon can be considered in most cases as a physiological process associated with tissue repair, exaggerated IRE could have physiopathological consequences. On the other hand, the influence of several factors such as age, sex, training, hormonal status, nutrition, anti-inflammatory drugs, and the extent to which IRE could be a potential risk for subjects undergoing intense physical training require further study. |
| format | Article |
| id | doaj-art-3f7e9a6646ff4e6b8e3767f5bec283eb |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1993-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3f7e9a6646ff4e6b8e3767f5bec283eb2025-08-20T02:08:08ZengWileyMediators of Inflammation0962-93511466-18611993-01-012533534210.1155/S0962935193000468Inflammatory response to strenuous muscular exercise in manG. Camus0G. Deby-Dupont1C. Deby2A. Juchmès-Ferir3J. Pincemail4M. Lamy5Research Associate, FNRS, Laboratory of Human Applied Physiology, ISEPK, B21, University of Liège, Sart Tilman, Liège 4000, BelgiumDepartment of Anesthesiology, CHU, B35, University of Liège, Sart Tilman, Liège 4000, BelgiumCenter for the Biochemistry of Oxygen, Institute of Chemistry, B6, University of Liège, Sart Tilman, Liège 4000, BelgiumDepartment of Clinical Biology, University of Liège, Sart Tilman, Liège 4000, BelgiumCenter for the Biochemistry of Oxygen, Institute of Chemistry, B6, University of Liège, Sart Tilman, Liège 4000, BelgiumCenter for the Biochemistry of Oxygen, Institute of Chemistry, B6, University of Liège, Sart Tilman, Liège 4000, BelgiumBased on the humoral and cellular changes occurring during strenuous muscular work in humans, the concept of inflammatory response to exercise (IRE) is developed. The main indices of IRE consist of signs of an acute phase response, leucocytosis and leucocyte activation, release of inflammatory mediators, tissue damage and cellular infiltrates, production of free radicals, activation of complement, and coagulation and fibrinolytic pathways. Depending on exercise intensity and duration, it seems likely that muscle and/or associated connective tissue damage, contact system activation due to shear stress on endothelium and endotoxaemia could be the triggering mechanisms of IRE. Although this phenomenon can be considered in most cases as a physiological process associated with tissue repair, exaggerated IRE could have physiopathological consequences. On the other hand, the influence of several factors such as age, sex, training, hormonal status, nutrition, anti-inflammatory drugs, and the extent to which IRE could be a potential risk for subjects undergoing intense physical training require further study.http://dx.doi.org/10.1155/S0962935193000468 |
| spellingShingle | G. Camus G. Deby-Dupont C. Deby A. Juchmès-Ferir J. Pincemail M. Lamy Inflammatory response to strenuous muscular exercise in man Mediators of Inflammation |
| title | Inflammatory response to strenuous muscular exercise in man |
| title_full | Inflammatory response to strenuous muscular exercise in man |
| title_fullStr | Inflammatory response to strenuous muscular exercise in man |
| title_full_unstemmed | Inflammatory response to strenuous muscular exercise in man |
| title_short | Inflammatory response to strenuous muscular exercise in man |
| title_sort | inflammatory response to strenuous muscular exercise in man |
| url | http://dx.doi.org/10.1155/S0962935193000468 |
| work_keys_str_mv | AT gcamus inflammatoryresponsetostrenuousmuscularexerciseinman AT gdebydupont inflammatoryresponsetostrenuousmuscularexerciseinman AT cdeby inflammatoryresponsetostrenuousmuscularexerciseinman AT ajuchmesferir inflammatoryresponsetostrenuousmuscularexerciseinman AT jpincemail inflammatoryresponsetostrenuousmuscularexerciseinman AT mlamy inflammatoryresponsetostrenuousmuscularexerciseinman |