Safety of Allogeneic Canine Adipose Tissue-Derived Mesenchymal Stem Cell Intraspinal Transplantation in Dogs with Chronic Spinal Cord Injury
This is a pilot clinical study primarily designed to assess the feasibility and safety of X-ray-guided percutaneous intraspinal injection of allogeneic canine adipose tissue-derived mesenchymal stem cells in dogs with chronic spinal cord injury. Six dogs with chronic paraplegia (≥six months) were in...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/3053759 |
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| author | Cláudia Cardoso Maciel Escalhão Isalira Peroba Ramos Camila Hochman-Mendez Tais Hanae Kasai Brunswick Sergio Augusto Lopes Souza Bianca Gutfilen Regina Coeli dos Santos Goldenberg Tatiana Coelho-Sampaio |
| author_facet | Cláudia Cardoso Maciel Escalhão Isalira Peroba Ramos Camila Hochman-Mendez Tais Hanae Kasai Brunswick Sergio Augusto Lopes Souza Bianca Gutfilen Regina Coeli dos Santos Goldenberg Tatiana Coelho-Sampaio |
| author_sort | Cláudia Cardoso Maciel Escalhão |
| collection | DOAJ |
| description | This is a pilot clinical study primarily designed to assess the feasibility and safety of X-ray-guided percutaneous intraspinal injection of allogeneic canine adipose tissue-derived mesenchymal stem cells in dogs with chronic spinal cord injury. Six dogs with chronic paraplegia (≥six months) were intraparenchymally injected with allogeneic cells in the site of lesion. Cells were obtained from subcutaneous adipose tissue of a healthy dog, cultured to passage 3, labeled with 99mTechnetium, and transplanted into the lesion by percutaneous X-ray-guided injection. Digital X-ray efficiently guided cell injection as 99mTechnetium-labeled cells remained in the injection site for at least 24 hours after transplantation. No adverse effects or complications (infection, neuropathic pain, or worsening of neurological function) were observed during the 16-week follow-up period after transplantation. Three animals improved locomotion as assessed by the Olby scale. One animal walked without support, but no changes in deep pain perception were observed. We conclude that X-ray-guided percutaneous intraspinal transplantation of allogeneic cells in dogs with chronic spinal cord injury is feasible and safe. The efficacy of the treatment will be assessed in a new study involving a larger number of animals. |
| format | Article |
| id | doaj-art-3f7876e05d26496783d17ee42c35ff5a |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-3f7876e05d26496783d17ee42c35ff5a2025-08-20T03:35:53ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/30537593053759Safety of Allogeneic Canine Adipose Tissue-Derived Mesenchymal Stem Cell Intraspinal Transplantation in Dogs with Chronic Spinal Cord InjuryCláudia Cardoso Maciel Escalhão0Isalira Peroba Ramos1Camila Hochman-Mendez2Tais Hanae Kasai Brunswick3Sergio Augusto Lopes Souza4Bianca Gutfilen5Regina Coeli dos Santos Goldenberg6Tatiana Coelho-Sampaio7Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Ave. Carlos Chagas Filho 373, Sala B1-011, Cidade Universitária, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, BrazilInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Ave. Carlos Chagas Filho 373, Sala G2-053, Cidade Universitária, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, BrazilInstitute of Biomedical Sciences, Federal University of Rio de Janeiro, Ave. Carlos Chagas Filho 373, Sala B1-011, Cidade Universitária, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, BrazilInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Ave. Carlos Chagas Filho 373, Sala G2-053, Cidade Universitária, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, BrazilDepartment of Radiology, University Hospital Clementino Fraga Filho and Federal University of Rio de Janeiro, Rua Prof Rodolpho Paulo Rocco, No. 255, Sala ss29, Cidade Universitária, Ilha do Fundão, 21941-913 Rio de Janeiro, RJ, BrazilDepartment of Radiology, University Hospital Clementino Fraga Filho and Federal University of Rio de Janeiro, Rua Prof Rodolpho Paulo Rocco, No. 255, Sala ss29, Cidade Universitária, Ilha do Fundão, 21941-913 Rio de Janeiro, RJ, BrazilInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Ave. Carlos Chagas Filho 373, Sala G2-053, Cidade Universitária, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, BrazilInstitute of Biomedical Sciences, Federal University of Rio de Janeiro, Ave. Carlos Chagas Filho 373, Sala B1-011, Cidade Universitária, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, BrazilThis is a pilot clinical study primarily designed to assess the feasibility and safety of X-ray-guided percutaneous intraspinal injection of allogeneic canine adipose tissue-derived mesenchymal stem cells in dogs with chronic spinal cord injury. Six dogs with chronic paraplegia (≥six months) were intraparenchymally injected with allogeneic cells in the site of lesion. Cells were obtained from subcutaneous adipose tissue of a healthy dog, cultured to passage 3, labeled with 99mTechnetium, and transplanted into the lesion by percutaneous X-ray-guided injection. Digital X-ray efficiently guided cell injection as 99mTechnetium-labeled cells remained in the injection site for at least 24 hours after transplantation. No adverse effects or complications (infection, neuropathic pain, or worsening of neurological function) were observed during the 16-week follow-up period after transplantation. Three animals improved locomotion as assessed by the Olby scale. One animal walked without support, but no changes in deep pain perception were observed. We conclude that X-ray-guided percutaneous intraspinal transplantation of allogeneic cells in dogs with chronic spinal cord injury is feasible and safe. The efficacy of the treatment will be assessed in a new study involving a larger number of animals.http://dx.doi.org/10.1155/2017/3053759 |
| spellingShingle | Cláudia Cardoso Maciel Escalhão Isalira Peroba Ramos Camila Hochman-Mendez Tais Hanae Kasai Brunswick Sergio Augusto Lopes Souza Bianca Gutfilen Regina Coeli dos Santos Goldenberg Tatiana Coelho-Sampaio Safety of Allogeneic Canine Adipose Tissue-Derived Mesenchymal Stem Cell Intraspinal Transplantation in Dogs with Chronic Spinal Cord Injury Stem Cells International |
| title | Safety of Allogeneic Canine Adipose Tissue-Derived Mesenchymal Stem Cell Intraspinal Transplantation in Dogs with Chronic Spinal Cord Injury |
| title_full | Safety of Allogeneic Canine Adipose Tissue-Derived Mesenchymal Stem Cell Intraspinal Transplantation in Dogs with Chronic Spinal Cord Injury |
| title_fullStr | Safety of Allogeneic Canine Adipose Tissue-Derived Mesenchymal Stem Cell Intraspinal Transplantation in Dogs with Chronic Spinal Cord Injury |
| title_full_unstemmed | Safety of Allogeneic Canine Adipose Tissue-Derived Mesenchymal Stem Cell Intraspinal Transplantation in Dogs with Chronic Spinal Cord Injury |
| title_short | Safety of Allogeneic Canine Adipose Tissue-Derived Mesenchymal Stem Cell Intraspinal Transplantation in Dogs with Chronic Spinal Cord Injury |
| title_sort | safety of allogeneic canine adipose tissue derived mesenchymal stem cell intraspinal transplantation in dogs with chronic spinal cord injury |
| url | http://dx.doi.org/10.1155/2017/3053759 |
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