Coniontins, lipopetaibiotics active against Candida auris identified from a microbial natural product fractionation library

Coniontins, lipopetaibiotics active against Candida auris identified from a microbial natural product fractionation library

Abstract The rise of drug-resistant fungal pathogens, including Candida auris, highlights the urgent need for innovative antifungal therapies. We have developed a cost-effective platform combining microbial extract prefractionation with rapid mass spectrometry-bioinformatics-based dereplication to e...

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Main Authors: Xuefei Chen, Kalinka Koteva, Sommer Chou, Allison Guitor, Daniel Pallant, Yunjin Lee, David Sychantha, Shawn French, Dirk Hackenberger, Nicole Robbins, Michael A. Cook, Eric D. Brown, Lesley T. MacNeil, Leah E. Cowen, Gerard D. Wright
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62630-z
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