Non-Invasive Detection of Tumors by Volatile Organic Compounds in Urine
Cancer is one of the major causes of death, and as it becomes more malignant, it becomes an intractable disease that is difficult to cure completely. Therefore, early detection is important to increase the survival rate. For this reason, testing with blood biomarkers is currently common. However, in...
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| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/1/109 |
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| author | Tomoaki Hara Sikun Meng Yasuko Arao Yoshiko Saito Kana Inoue Aya Hasan Alshammari Hideyuki Hatakeyama Eric di Luccio Andrea Vecchione Takaaki Hirotsu Hideshi Ishii |
| author_facet | Tomoaki Hara Sikun Meng Yasuko Arao Yoshiko Saito Kana Inoue Aya Hasan Alshammari Hideyuki Hatakeyama Eric di Luccio Andrea Vecchione Takaaki Hirotsu Hideshi Ishii |
| author_sort | Tomoaki Hara |
| collection | DOAJ |
| description | Cancer is one of the major causes of death, and as it becomes more malignant, it becomes an intractable disease that is difficult to cure completely. Therefore, early detection is important to increase the survival rate. For this reason, testing with blood biomarkers is currently common. However, in order to accurately diagnose early-stage cancer, new biomarkers and diagnostic methods that enable highly accurate diagnosis are needed. This review summarizes recent studies on cancer biomarker detection. In particular, we focus on the analysis of volatile organic compounds (VOCs) in urine and the development of diagnostic methods using olfactory receptors in living organisms. Urinary samples from cancer patients contain a wide variety of VOCs, and the identification of cancer specific compounds is underway. It has also been found that the olfactory sense of organisms can distinguish cancer-specific odors, which may be applicable to cancer diagnosis. We explore the possibility of novel cancer biomarker candidates and novel diagnostic methods. |
| format | Article |
| id | doaj-art-3f777a30da544310b8627ddb8d1debbb |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-3f777a30da544310b8627ddb8d1debbb2025-01-24T13:24:02ZengMDPI AGBiomedicines2227-90592025-01-0113110910.3390/biomedicines13010109Non-Invasive Detection of Tumors by Volatile Organic Compounds in UrineTomoaki Hara0Sikun Meng1Yasuko Arao2Yoshiko Saito3Kana Inoue4Aya Hasan Alshammari5Hideyuki Hatakeyama6Eric di Luccio7Andrea Vecchione8Takaaki Hirotsu9Hideshi Ishii10Department of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, JapanHirotsu Bio Science Inc., Chiyoda-Ku, Tokyo 102-0094, JapanHirotsu Bio Science Inc., Chiyoda-Ku, Tokyo 102-0094, JapanHirotsu Bio Science Inc., Chiyoda-Ku, Tokyo 102-0094, JapanDepartment of Clinical and Molecular Medicine, University of Rome “Sapienza”, Santo Andrea Hospital, Via di Grottarossa, 1035-00189 Rome, ItalyHirotsu Bio Science Inc., Chiyoda-Ku, Tokyo 102-0094, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, JapanCancer is one of the major causes of death, and as it becomes more malignant, it becomes an intractable disease that is difficult to cure completely. Therefore, early detection is important to increase the survival rate. For this reason, testing with blood biomarkers is currently common. However, in order to accurately diagnose early-stage cancer, new biomarkers and diagnostic methods that enable highly accurate diagnosis are needed. This review summarizes recent studies on cancer biomarker detection. In particular, we focus on the analysis of volatile organic compounds (VOCs) in urine and the development of diagnostic methods using olfactory receptors in living organisms. Urinary samples from cancer patients contain a wide variety of VOCs, and the identification of cancer specific compounds is underway. It has also been found that the olfactory sense of organisms can distinguish cancer-specific odors, which may be applicable to cancer diagnosis. We explore the possibility of novel cancer biomarker candidates and novel diagnostic methods.https://www.mdpi.com/2227-9059/13/1/109cancerbiomarkersdiagnosticsvolatile organic compoundsolfactory receptors |
| spellingShingle | Tomoaki Hara Sikun Meng Yasuko Arao Yoshiko Saito Kana Inoue Aya Hasan Alshammari Hideyuki Hatakeyama Eric di Luccio Andrea Vecchione Takaaki Hirotsu Hideshi Ishii Non-Invasive Detection of Tumors by Volatile Organic Compounds in Urine Biomedicines cancer biomarkers diagnostics volatile organic compounds olfactory receptors |
| title | Non-Invasive Detection of Tumors by Volatile Organic Compounds in Urine |
| title_full | Non-Invasive Detection of Tumors by Volatile Organic Compounds in Urine |
| title_fullStr | Non-Invasive Detection of Tumors by Volatile Organic Compounds in Urine |
| title_full_unstemmed | Non-Invasive Detection of Tumors by Volatile Organic Compounds in Urine |
| title_short | Non-Invasive Detection of Tumors by Volatile Organic Compounds in Urine |
| title_sort | non invasive detection of tumors by volatile organic compounds in urine |
| topic | cancer biomarkers diagnostics volatile organic compounds olfactory receptors |
| url | https://www.mdpi.com/2227-9059/13/1/109 |
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