Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Treatment of Parkinson’s Disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the gradual loss of dopamine-producing neurons. Oxidative stress, mitochondrial dysfunction, detrimental immune response, and neuroinflammation are mainly responsible for the injury and degeneration of dopaminergic...
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MDPI AG
2025-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/8/600 |
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| author | Ana Volarevic Carl Randall Harrell Aleksandar Arsenijevic Valentin Djonov Vladislav Volarevic |
| author_facet | Ana Volarevic Carl Randall Harrell Aleksandar Arsenijevic Valentin Djonov Vladislav Volarevic |
| author_sort | Ana Volarevic |
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| description | Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the gradual loss of dopamine-producing neurons. Oxidative stress, mitochondrial dysfunction, detrimental immune response, and neuroinflammation are mainly responsible for the injury and degeneration of dopaminergic neurons in the brains of patients suffering from PD. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as a promising therapeutic approach for treating PD due to their ability to suppress the activation of inflammatory immune cells and enhance the viability and function of dopamine-producing neurons. MSC-EVs can easily bypass the blood-brain barrier and deliver their cargo (neuroprotective factors, immunosuppressive proteins, and microRNAs) to injured dopamine-producing neurons and brain-infiltrated inflammatory immune cells. A large number of recently published experimental studies demonstrated that MSC-EVs efficiently alleviated PD-related motor and behavioral deficits in animal models, indicating that MSC-EVs should be considered as potentially new therapeutic agents for the treatment of PD. Accordingly, in this review article, we summarized current knowledge about the therapeutic potential of MSCs-EVs in the treatment of PD, paving the way for their future clinical use in the treatment of neurodegenerative and neuroinflammatory disorders. |
| format | Article |
| id | doaj-art-3f76c3e42836477db4ab112a2b5e6db4 |
| institution | OA Journals |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-04-01 |
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| series | Cells |
| spelling | doaj-art-3f76c3e42836477db4ab112a2b5e6db42025-08-20T02:24:42ZengMDPI AGCells2073-44092025-04-0114860010.3390/cells14080600Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Treatment of Parkinson’s DiseaseAna Volarevic0Carl Randall Harrell1Aleksandar Arsenijevic2Valentin Djonov3Vladislav Volarevic4Departments of Psychology, Center for Research on Harmful Effects of Biological and Chemical Hazards, Faculty of Medical Sciences University of Kragujevac, 69 Svetozara Markovica Street, 34000 Kragujevac, SerbiaRegenerative Processing Plant, LLC, 34176 US Highway 19 N, Palm Harbor, FL 34684, USADepartments of Genetics, Microbiology and Immunology, Center for Research on Harmful Effects of Biological and Chemical Hazards, Faculty of Medical Sciences University of Kragujevac, 69 Svetozara Markovica Street, 34000 Kragujevac, SerbiaInstitute of Anatomy, University of Bern, Baltzerstrasse 2, 3012 Bern, SwitzerlandDepartments of Genetics, Microbiology and Immunology, Center for Research on Harmful Effects of Biological and Chemical Hazards, Faculty of Medical Sciences University of Kragujevac, 69 Svetozara Markovica Street, 34000 Kragujevac, SerbiaParkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the gradual loss of dopamine-producing neurons. Oxidative stress, mitochondrial dysfunction, detrimental immune response, and neuroinflammation are mainly responsible for the injury and degeneration of dopaminergic neurons in the brains of patients suffering from PD. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as a promising therapeutic approach for treating PD due to their ability to suppress the activation of inflammatory immune cells and enhance the viability and function of dopamine-producing neurons. MSC-EVs can easily bypass the blood-brain barrier and deliver their cargo (neuroprotective factors, immunosuppressive proteins, and microRNAs) to injured dopamine-producing neurons and brain-infiltrated inflammatory immune cells. A large number of recently published experimental studies demonstrated that MSC-EVs efficiently alleviated PD-related motor and behavioral deficits in animal models, indicating that MSC-EVs should be considered as potentially new therapeutic agents for the treatment of PD. Accordingly, in this review article, we summarized current knowledge about the therapeutic potential of MSCs-EVs in the treatment of PD, paving the way for their future clinical use in the treatment of neurodegenerative and neuroinflammatory disorders.https://www.mdpi.com/2073-4409/14/8/600mesenchymal stem cellsextracellular vesiclesParkinson’s diseasetherapydopaminergic neurons |
| spellingShingle | Ana Volarevic Carl Randall Harrell Aleksandar Arsenijevic Valentin Djonov Vladislav Volarevic Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Treatment of Parkinson’s Disease Cells mesenchymal stem cells extracellular vesicles Parkinson’s disease therapy dopaminergic neurons |
| title | Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Treatment of Parkinson’s Disease |
| title_full | Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Treatment of Parkinson’s Disease |
| title_fullStr | Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Treatment of Parkinson’s Disease |
| title_full_unstemmed | Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Treatment of Parkinson’s Disease |
| title_short | Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Treatment of Parkinson’s Disease |
| title_sort | therapeutic potential of mesenchymal stem cell derived extracellular vesicles in the treatment of parkinson s disease |
| topic | mesenchymal stem cells extracellular vesicles Parkinson’s disease therapy dopaminergic neurons |
| url | https://www.mdpi.com/2073-4409/14/8/600 |
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