Clinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patients
Adolescent and young adult (AYA, 15–39 years old) patients with papillary thyroid carcinoma (PTC) experience significant psychological distress and place great importance on obtaining information regarding the disease; however, their demands remain unmet. We aimed to investigate clinicopathological...
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| Format: | Article |
| Language: | English |
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The Japan Endocrine Society
2025-02-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/72/2/72_EJ24-0504/_html/-char/en |
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| author | Van Phu Thang Nguyen Hirokazu Kurohama Yuko Akazawa Thi Ngoc Anh Nguyen Katsuya Matsuda Yuki Matsuoka Zhanna Mussazhanova Kenichi Yokota Shinya Satoh Hiroyuki Yamashita Thi Nhung Nguyen Yerkerzhan Sailaubekova Masahiro Nakashima |
| author_facet | Van Phu Thang Nguyen Hirokazu Kurohama Yuko Akazawa Thi Ngoc Anh Nguyen Katsuya Matsuda Yuki Matsuoka Zhanna Mussazhanova Kenichi Yokota Shinya Satoh Hiroyuki Yamashita Thi Nhung Nguyen Yerkerzhan Sailaubekova Masahiro Nakashima |
| author_sort | Van Phu Thang Nguyen |
| collection | DOAJ |
| description | Adolescent and young adult (AYA, 15–39 years old) patients with papillary thyroid carcinoma (PTC) experience significant psychological distress and place great importance on obtaining information regarding the disease; however, their demands remain unmet. We aimed to investigate clinicopathological and molecular features of PTC in AYA patients and compare them to those of PTC in older patients (≥40 years). This retrospective study enrolled 1,677 patients diagnosed with PTC from January 2018 to December 2022, with 400 AYA patients and 1,277 older adults. At the time of diagnosis, AYA patients with PTC had higher rates of presentation in females, larger tumor size (>2.0 cm), lymphatic vessel invasion, chronic thyroiditis, clinical lymph node metastasis, and pathologic lymph node metastasis, but lower rates of multifocality and extrathyroidal extension compared with PTC in older adults. The two groups had no significant differences regarding surgical method and distant metastasis. The prevalences of BRAF p.V600E and TERT promoter mutations of PTC were significantly lower in AYA patients (69.1% vs. 82.6% and 1.3% vs. 18.8%, respectively; both p < 0.001). In conclusion, PTC in AYA patients differed from PTC in older patients. Particularly, BRAF p.V600E and TERT promoter mutations in AYA with PTC were less frequently observed than in older adults. |
| format | Article |
| id | doaj-art-3f7444afef704547b16dfd1187aed437 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-3f7444afef704547b16dfd1187aed4372025-02-03T01:08:32ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402025-02-0172222122710.1507/endocrj.EJ24-0504endocrjClinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patientsVan Phu Thang Nguyen0Hirokazu Kurohama1Yuko Akazawa2Thi Ngoc Anh Nguyen3Katsuya Matsuda4Yuki Matsuoka5Zhanna Mussazhanova6Kenichi Yokota7Shinya Satoh8Hiroyuki Yamashita9Thi Nhung Nguyen10Yerkerzhan Sailaubekova11Masahiro Nakashima12Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, JapanDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, JapanDepartment of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, JapanDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, JapanDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, JapanDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, JapanDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, JapanBiostatistics Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, JapanYamashita Thyroid Hospital, Fukuoka 812-0034, JapanYamashita Thyroid Hospital, Fukuoka 812-0034, JapanDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, JapanDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, JapanDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, JapanAdolescent and young adult (AYA, 15–39 years old) patients with papillary thyroid carcinoma (PTC) experience significant psychological distress and place great importance on obtaining information regarding the disease; however, their demands remain unmet. We aimed to investigate clinicopathological and molecular features of PTC in AYA patients and compare them to those of PTC in older patients (≥40 years). This retrospective study enrolled 1,677 patients diagnosed with PTC from January 2018 to December 2022, with 400 AYA patients and 1,277 older adults. At the time of diagnosis, AYA patients with PTC had higher rates of presentation in females, larger tumor size (>2.0 cm), lymphatic vessel invasion, chronic thyroiditis, clinical lymph node metastasis, and pathologic lymph node metastasis, but lower rates of multifocality and extrathyroidal extension compared with PTC in older adults. The two groups had no significant differences regarding surgical method and distant metastasis. The prevalences of BRAF p.V600E and TERT promoter mutations of PTC were significantly lower in AYA patients (69.1% vs. 82.6% and 1.3% vs. 18.8%, respectively; both p < 0.001). In conclusion, PTC in AYA patients differed from PTC in older patients. Particularly, BRAF p.V600E and TERT promoter mutations in AYA with PTC were less frequently observed than in older adults.https://www.jstage.jst.go.jp/article/endocrj/72/2/72_EJ24-0504/_html/-char/enadolescent and young adult (aya)papillary thyroid carcinomaclinicopathological featuresmoleculartumor recurrence |
| spellingShingle | Van Phu Thang Nguyen Hirokazu Kurohama Yuko Akazawa Thi Ngoc Anh Nguyen Katsuya Matsuda Yuki Matsuoka Zhanna Mussazhanova Kenichi Yokota Shinya Satoh Hiroyuki Yamashita Thi Nhung Nguyen Yerkerzhan Sailaubekova Masahiro Nakashima Clinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patients Endocrine Journal adolescent and young adult (aya) papillary thyroid carcinoma clinicopathological features molecular tumor recurrence |
| title | Clinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patients |
| title_full | Clinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patients |
| title_fullStr | Clinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patients |
| title_full_unstemmed | Clinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patients |
| title_short | Clinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patients |
| title_sort | clinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patients |
| topic | adolescent and young adult (aya) papillary thyroid carcinoma clinicopathological features molecular tumor recurrence |
| url | https://www.jstage.jst.go.jp/article/endocrj/72/2/72_EJ24-0504/_html/-char/en |
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