An Item Response Theory Model for Functional Assessment of Spinal Muscular Atrophy Based on the Hammersmith Functional Motor Scale Expanded
ObjectiveTo establish an item response theory (IRT) model for functional assessment of spinal muscular atrophy based on the Hammersmith functional motor scale expanded.MethodsA total of 23 patients with SMA were treated with corrective treatment in the Department of Geriatric Neurology and the Depar...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Editorial Office of Rehabilitation Medicine
2024-12-01
|
| Series: | 康复学报 |
| Subjects: | |
| Online Access: | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2024.06011 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850183791339896832 |
|---|---|
| author | FAN Yabei CHEN Jinjin GE Panli CHENG Xi ZHANG Yichen LIN Feng |
| author_facet | FAN Yabei CHEN Jinjin GE Panli CHENG Xi ZHANG Yichen LIN Feng |
| author_sort | FAN Yabei |
| collection | DOAJ |
| description | ObjectiveTo establish an item response theory (IRT) model for functional assessment of spinal muscular atrophy based on the Hammersmith functional motor scale expanded.MethodsA total of 23 patients with SMA were treated with corrective treatment in the Department of Geriatric Neurology and the Department of Pediatrics of the First Affiliated Hospital with Nanjing Medical University from February 2021 to June 2023. IRT was constructed using these repeated measurement data based on stack design. The comparisons between well-fitted models were based on likelihood ratio. And item guessing, carelessness, difficultyand personal abilities (θ) of selected optimal model were calculated. Differential test functioning (DTF) test was conducted for gender and rehabilitation therapy to test the bias. Monte Carlo simulation was used to prove that the item difficulty distribution of the model was not affected by the sampling process. And person-item plot was drawn according to the median expected difficulty. and the differences in the difficulty of each item in HFMSE scale and personal abilities among each evaluations were discussed.ResultsA total of 32items were included in this study and 4 alternative models were constructed. Three-parametric logistic model was selected as the optimal model with the best fitness (P＞0.05, M2 statistics = 479.75). In 3PLM, the caution of all items was 1, and the discrimination, guessing and difficulty of the items were calculated. There were no DTFs for gender and rehabilitation therapy. The results showed high reliability (Cronbach's α = 0.955, LCRC = 0.981) and validity [θ value is positively correlated with the original total score (P<0.001, r = 0.99)] of 3PLM. There was conversion between personal abilities θ value and the total score of the scale:θ=-1.63 + 0.0651TTS－1.39×10-5TTS2. A person-item plot showing the location of item parameters and individual parameters on the personal abilities (θ) scale was used to observe the relationship between θ values and item difficulties.ConclusionThe IRT model based on HFMSE offered a new approach to evaluate functional levels of SMA patients and difficulties of items. The calculation of item guessing, carelessness and difficulty of selected optimal model provides recommendations for better clinical practice of HFMSE. The study offers a new perspective for the assessment of the functions of SMA patients and guidance for the development of rehabilitation programs. |
| format | Article |
| id | doaj-art-3f73e947c2064b83bf0cdcdccc5a1273 |
| institution | OA Journals |
| issn | 2096-0328 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Editorial Office of Rehabilitation Medicine |
| record_format | Article |
| series | 康复学报 |
| spelling | doaj-art-3f73e947c2064b83bf0cdcdccc5a12732025-08-20T02:17:14ZengEditorial Office of Rehabilitation Medicine康复学报2096-03282024-12-013460461076587297An Item Response Theory Model for Functional Assessment of Spinal Muscular Atrophy Based on the Hammersmith Functional Motor Scale ExpandedFAN YabeiCHEN JinjinGE PanliCHENG XiZHANG YichenLIN FengObjectiveTo establish an item response theory (IRT) model for functional assessment of spinal muscular atrophy based on the Hammersmith functional motor scale expanded.MethodsA total of 23 patients with SMA were treated with corrective treatment in the Department of Geriatric Neurology and the Department of Pediatrics of the First Affiliated Hospital with Nanjing Medical University from February 2021 to June 2023. IRT was constructed using these repeated measurement data based on stack design. The comparisons between well-fitted models were based on likelihood ratio. And item guessing, carelessness, difficultyand personal abilities (θ) of selected optimal model were calculated. Differential test functioning (DTF) test was conducted for gender and rehabilitation therapy to test the bias. Monte Carlo simulation was used to prove that the item difficulty distribution of the model was not affected by the sampling process. And person-item plot was drawn according to the median expected difficulty. and the differences in the difficulty of each item in HFMSE scale and personal abilities among each evaluations were discussed.ResultsA total of 32items were included in this study and 4 alternative models were constructed. Three-parametric logistic model was selected as the optimal model with the best fitness (P＞0.05, M2 statistics = 479.75). In 3PLM, the caution of all items was 1, and the discrimination, guessing and difficulty of the items were calculated. There were no DTFs for gender and rehabilitation therapy. The results showed high reliability (Cronbach's α = 0.955, LCRC = 0.981) and validity [θ value is positively correlated with the original total score (P<0.001, r = 0.99)] of 3PLM. There was conversion between personal abilities θ value and the total score of the scale:θ=-1.63 + 0.0651TTS－1.39×10-5TTS2. A person-item plot showing the location of item parameters and individual parameters on the personal abilities (θ) scale was used to observe the relationship between θ values and item difficulties.ConclusionThe IRT model based on HFMSE offered a new approach to evaluate functional levels of SMA patients and difficulties of items. The calculation of item guessing, carelessness and difficulty of selected optimal model provides recommendations for better clinical practice of HFMSE. The study offers a new perspective for the assessment of the functions of SMA patients and guidance for the development of rehabilitation programs.http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2024.06011spinal muscular atrophyHammersmith functional motor scale expandeditem response theoryfunctional analysis |
| spellingShingle | FAN Yabei CHEN Jinjin GE Panli CHENG Xi ZHANG Yichen LIN Feng An Item Response Theory Model for Functional Assessment of Spinal Muscular Atrophy Based on the Hammersmith Functional Motor Scale Expanded 康复学报 spinal muscular atrophy Hammersmith functional motor scale expanded item response theory functional analysis |
| title | An Item Response Theory Model for Functional Assessment of Spinal Muscular Atrophy Based on the Hammersmith Functional Motor Scale Expanded |
| title_full | An Item Response Theory Model for Functional Assessment of Spinal Muscular Atrophy Based on the Hammersmith Functional Motor Scale Expanded |
| title_fullStr | An Item Response Theory Model for Functional Assessment of Spinal Muscular Atrophy Based on the Hammersmith Functional Motor Scale Expanded |
| title_full_unstemmed | An Item Response Theory Model for Functional Assessment of Spinal Muscular Atrophy Based on the Hammersmith Functional Motor Scale Expanded |
| title_short | An Item Response Theory Model for Functional Assessment of Spinal Muscular Atrophy Based on the Hammersmith Functional Motor Scale Expanded |
| title_sort | item response theory model for functional assessment of spinal muscular atrophy based on the hammersmith functional motor scale expanded |
| topic | spinal muscular atrophy Hammersmith functional motor scale expanded item response theory functional analysis |
| url | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2024.06011 |
| work_keys_str_mv | AT fanyabei anitemresponsetheorymodelforfunctionalassessmentofspinalmuscularatrophybasedonthehammersmithfunctionalmotorscaleexpanded AT chenjinjin anitemresponsetheorymodelforfunctionalassessmentofspinalmuscularatrophybasedonthehammersmithfunctionalmotorscaleexpanded AT gepanli anitemresponsetheorymodelforfunctionalassessmentofspinalmuscularatrophybasedonthehammersmithfunctionalmotorscaleexpanded AT chengxi anitemresponsetheorymodelforfunctionalassessmentofspinalmuscularatrophybasedonthehammersmithfunctionalmotorscaleexpanded AT zhangyichen anitemresponsetheorymodelforfunctionalassessmentofspinalmuscularatrophybasedonthehammersmithfunctionalmotorscaleexpanded AT linfeng anitemresponsetheorymodelforfunctionalassessmentofspinalmuscularatrophybasedonthehammersmithfunctionalmotorscaleexpanded AT fanyabei itemresponsetheorymodelforfunctionalassessmentofspinalmuscularatrophybasedonthehammersmithfunctionalmotorscaleexpanded AT chenjinjin itemresponsetheorymodelforfunctionalassessmentofspinalmuscularatrophybasedonthehammersmithfunctionalmotorscaleexpanded AT gepanli itemresponsetheorymodelforfunctionalassessmentofspinalmuscularatrophybasedonthehammersmithfunctionalmotorscaleexpanded AT chengxi itemresponsetheorymodelforfunctionalassessmentofspinalmuscularatrophybasedonthehammersmithfunctionalmotorscaleexpanded AT zhangyichen itemresponsetheorymodelforfunctionalassessmentofspinalmuscularatrophybasedonthehammersmithfunctionalmotorscaleexpanded AT linfeng itemresponsetheorymodelforfunctionalassessmentofspinalmuscularatrophybasedonthehammersmithfunctionalmotorscaleexpanded |