Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications
Burns are soft tissue injuries that require particular care for wound healing. Current tissue engineering approaches are aimed at identifying the most efficient treatment combinations to restore the tissue properties and function by using adapted scaffolds or delivery platforms for tissue repair and...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/4513108 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552349862723584 |
|---|---|
| author | Sorina Dinescu Simona Rebeca Ignat Andreea Daniela Lazar Ștefania Marin Elena Danilă Maria M. Marin Denisa Ioana Udeanu Mihaela Violeta Ghica Mădălina G. Albu-Kaya Marieta Costache |
| author_facet | Sorina Dinescu Simona Rebeca Ignat Andreea Daniela Lazar Ștefania Marin Elena Danilă Maria M. Marin Denisa Ioana Udeanu Mihaela Violeta Ghica Mădălina G. Albu-Kaya Marieta Costache |
| author_sort | Sorina Dinescu |
| collection | DOAJ |
| description | Burns are soft tissue injuries that require particular care for wound healing. Current tissue engineering approaches are aimed at identifying the most efficient treatment combinations to restore the tissue properties and function by using adapted scaffolds or delivery platforms for tissue repair and regeneration by triggering molecules. To reduce the inflammation associated with skin burns, the addition of an anti-inflammatory factor in these scaffolds would greatly increase the quality of the therapy. Therefore, this study is aimed at obtaining and validating a novel multiparticulate system based on a collagen matrix with controlled delivery of flufenamic acid anti-inflammatory drug for burn wound healing applications. In this work, we have characterized the properties and biocompatibility of these multiparticulate drug delivery systems (MDDS) and we have demonstrated their efficiency against burns and soft tissue lesions, particularly when the drug was microencapsulated, and thus with a controlled release. This study contributes to the advancement in therapy of burns and burn wound healing applications. |
| format | Article |
| id | doaj-art-3f7343408bf94346a02914eb960c8d8f |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-3f7343408bf94346a02914eb960c8d8f2025-02-03T05:58:54ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/45131084513108Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing ApplicationsSorina Dinescu0Simona Rebeca Ignat1Andreea Daniela Lazar2Ștefania Marin3Elena Danilă4Maria M. Marin5Denisa Ioana Udeanu6Mihaela Violeta Ghica7Mădălina G. Albu-Kaya8Marieta Costache9Department of Biochemistry and Molecular Biology, University of Bucharest, Bucharest 050095, RomaniaDepartment of Biochemistry and Molecular Biology, University of Bucharest, Bucharest 050095, RomaniaDepartment of Biochemistry and Molecular Biology, University of Bucharest, Bucharest 050095, RomaniaDepartment of Collagen Research, Division of Leather and Footwear Research Institute, The National Research & Development Institute for Textiles and Leather, Bucharest 031215, RomaniaDepartment of Collagen Research, Division of Leather and Footwear Research Institute, The National Research & Development Institute for Textiles and Leather, Bucharest 031215, RomaniaDepartment of Collagen Research, Division of Leather and Footwear Research Institute, The National Research & Development Institute for Textiles and Leather, Bucharest 031215, RomaniaDepartment of Clinical Laboratory and Food Safety, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest 020956, RomaniaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest 020956, RomaniaDepartment of Collagen Research, Division of Leather and Footwear Research Institute, The National Research & Development Institute for Textiles and Leather, Bucharest 031215, RomaniaDepartment of Biochemistry and Molecular Biology, University of Bucharest, Bucharest 050095, RomaniaBurns are soft tissue injuries that require particular care for wound healing. Current tissue engineering approaches are aimed at identifying the most efficient treatment combinations to restore the tissue properties and function by using adapted scaffolds or delivery platforms for tissue repair and regeneration by triggering molecules. To reduce the inflammation associated with skin burns, the addition of an anti-inflammatory factor in these scaffolds would greatly increase the quality of the therapy. Therefore, this study is aimed at obtaining and validating a novel multiparticulate system based on a collagen matrix with controlled delivery of flufenamic acid anti-inflammatory drug for burn wound healing applications. In this work, we have characterized the properties and biocompatibility of these multiparticulate drug delivery systems (MDDS) and we have demonstrated their efficiency against burns and soft tissue lesions, particularly when the drug was microencapsulated, and thus with a controlled release. This study contributes to the advancement in therapy of burns and burn wound healing applications.http://dx.doi.org/10.1155/2019/4513108 |
| spellingShingle | Sorina Dinescu Simona Rebeca Ignat Andreea Daniela Lazar Ștefania Marin Elena Danilă Maria M. Marin Denisa Ioana Udeanu Mihaela Violeta Ghica Mădălina G. Albu-Kaya Marieta Costache Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications Journal of Immunology Research |
| title | Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications |
| title_full | Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications |
| title_fullStr | Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications |
| title_full_unstemmed | Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications |
| title_short | Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications |
| title_sort | efficiency of multiparticulate delivery systems loaded with flufenamic acid designed for burn wound healing applications |
| url | http://dx.doi.org/10.1155/2019/4513108 |
| work_keys_str_mv | AT sorinadinescu efficiencyofmultiparticulatedeliverysystemsloadedwithflufenamicaciddesignedforburnwoundhealingapplications AT simonarebecaignat efficiencyofmultiparticulatedeliverysystemsloadedwithflufenamicaciddesignedforburnwoundhealingapplications AT andreeadanielalazar efficiencyofmultiparticulatedeliverysystemsloadedwithflufenamicaciddesignedforburnwoundhealingapplications AT stefaniamarin efficiencyofmultiparticulatedeliverysystemsloadedwithflufenamicaciddesignedforburnwoundhealingapplications AT elenadanila efficiencyofmultiparticulatedeliverysystemsloadedwithflufenamicaciddesignedforburnwoundhealingapplications AT mariammarin efficiencyofmultiparticulatedeliverysystemsloadedwithflufenamicaciddesignedforburnwoundhealingapplications AT denisaioanaudeanu efficiencyofmultiparticulatedeliverysystemsloadedwithflufenamicaciddesignedforburnwoundhealingapplications AT mihaelavioletaghica efficiencyofmultiparticulatedeliverysystemsloadedwithflufenamicaciddesignedforburnwoundhealingapplications AT madalinagalbukaya efficiencyofmultiparticulatedeliverysystemsloadedwithflufenamicaciddesignedforburnwoundhealingapplications AT marietacostache efficiencyofmultiparticulatedeliverysystemsloadedwithflufenamicaciddesignedforburnwoundhealingapplications |