A two-decade bibliometric analysis of tumor-associated macrophages in colorectal cancer research
Tumor-associated macrophages (TAMs), the predominant immune cells in the tumor microenvironment (TME), facilitate proliferation, invasion, metastasis, angiogenesis, chemoresistance, and immunosuppression in colorectal cancer (CRC). The mutual pathological mechanisms remain unclear, necessitating an...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2025.2512656 |
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| author | Yadi Gao Weichen Yuan Jiexiang Zhang Zhiwei Wang Wenwen Cui Zhongan Guan |
| author_facet | Yadi Gao Weichen Yuan Jiexiang Zhang Zhiwei Wang Wenwen Cui Zhongan Guan |
| author_sort | Yadi Gao |
| collection | DOAJ |
| description | Tumor-associated macrophages (TAMs), the predominant immune cells in the tumor microenvironment (TME), facilitate proliferation, invasion, metastasis, angiogenesis, chemoresistance, and immunosuppression in colorectal cancer (CRC). The mutual pathological mechanisms remain unclear, necessitating an in-depth study of the relationship between TAMs and CRC. This paper employs bibliometric methods to analyze TAMs and CRC research literature, aiming to assess current trends, evaluate the research status, and forecast future directions and emerging topics. We searched for publications published in the Web of Science Core Collection (WOSCC) database from January 1, 2001 to July 31, 2024. Following the establishment of specific search criteria for time, publication type, and language, bibliometric analysis and data visualization were conducted using Microsoft Excel, R software, VOSviewer, and CiteSpace. A total of 1,218 publications authored by 8,302 researchers across 61 countries and 1,657 institutions were analyzed. They were published in 427 journals, covering 4,451 keywords and citing 65,174 references. Keyword co-occurrence and literature co-citation analysis identified nuclear factor kappa-B, endothelial growth factor, angiogenesis, polarization, TME, immune response, programmed cell death protein 1 blockade, and metabolism as current research hotspots and trends in this field. Immune therapy and cancer-associated fibroblasts are key research areas, with the potential for further exploration of their mechanisms and targeted therapies. This paper employs bibliometric methods to comprehensively analyze and visualize research papers in TAMs and CRC. It analyzes the TAM-targeting research landscape in CRC, mapping current frontiers and translational potential to position TAMs as a promising immunotherapeutic strategy. |
| format | Article |
| id | doaj-art-3f71fc580ef04d4d80dfeff0c7446634 |
| institution | Kabale University |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-3f71fc580ef04d4d80dfeff0c74466342025-08-20T03:25:12ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2025.2512656A two-decade bibliometric analysis of tumor-associated macrophages in colorectal cancer researchYadi Gao0Weichen Yuan1Jiexiang Zhang2Zhiwei Wang3Wenwen Cui4Zhongan Guan5The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Oncology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaUrology Centre, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaTrauma Center, Binzhou Hospital of Traditional Chinese Medicine, Binzhou, ChinaColorectal Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaColorectal Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaTumor-associated macrophages (TAMs), the predominant immune cells in the tumor microenvironment (TME), facilitate proliferation, invasion, metastasis, angiogenesis, chemoresistance, and immunosuppression in colorectal cancer (CRC). The mutual pathological mechanisms remain unclear, necessitating an in-depth study of the relationship between TAMs and CRC. This paper employs bibliometric methods to analyze TAMs and CRC research literature, aiming to assess current trends, evaluate the research status, and forecast future directions and emerging topics. We searched for publications published in the Web of Science Core Collection (WOSCC) database from January 1, 2001 to July 31, 2024. Following the establishment of specific search criteria for time, publication type, and language, bibliometric analysis and data visualization were conducted using Microsoft Excel, R software, VOSviewer, and CiteSpace. A total of 1,218 publications authored by 8,302 researchers across 61 countries and 1,657 institutions were analyzed. They were published in 427 journals, covering 4,451 keywords and citing 65,174 references. Keyword co-occurrence and literature co-citation analysis identified nuclear factor kappa-B, endothelial growth factor, angiogenesis, polarization, TME, immune response, programmed cell death protein 1 blockade, and metabolism as current research hotspots and trends in this field. Immune therapy and cancer-associated fibroblasts are key research areas, with the potential for further exploration of their mechanisms and targeted therapies. This paper employs bibliometric methods to comprehensively analyze and visualize research papers in TAMs and CRC. It analyzes the TAM-targeting research landscape in CRC, mapping current frontiers and translational potential to position TAMs as a promising immunotherapeutic strategy.https://www.tandfonline.com/doi/10.1080/21645515.2025.2512656Tumor-associated macrophagescolorectal cancerbibliometricsresearch trendshot spots |
| spellingShingle | Yadi Gao Weichen Yuan Jiexiang Zhang Zhiwei Wang Wenwen Cui Zhongan Guan A two-decade bibliometric analysis of tumor-associated macrophages in colorectal cancer research Human Vaccines & Immunotherapeutics Tumor-associated macrophages colorectal cancer bibliometrics research trends hot spots |
| title | A two-decade bibliometric analysis of tumor-associated macrophages in colorectal cancer research |
| title_full | A two-decade bibliometric analysis of tumor-associated macrophages in colorectal cancer research |
| title_fullStr | A two-decade bibliometric analysis of tumor-associated macrophages in colorectal cancer research |
| title_full_unstemmed | A two-decade bibliometric analysis of tumor-associated macrophages in colorectal cancer research |
| title_short | A two-decade bibliometric analysis of tumor-associated macrophages in colorectal cancer research |
| title_sort | two decade bibliometric analysis of tumor associated macrophages in colorectal cancer research |
| topic | Tumor-associated macrophages colorectal cancer bibliometrics research trends hot spots |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2025.2512656 |
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