CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS
Аbstract. The aim of present study was to investigate an influence of polyclonal activators upon cytokine-producing function of peripheral blood cells in the patients with colorectal adenocarcinomas. It was revealed that the stimulated production of IL-1β, IL-1ra, IL-2, IL-17, IL-18 and IFNγ by whol...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/519 |
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| author | A. V. Sosnina A. I. Autenshlyus N. V. Velikaya N. A. Varaksin M. Yu. Rukhavishnikov E. S. Mikhailova D. V. Morozov S. A. Fursov N. V. Agarina |
| author_facet | A. V. Sosnina A. I. Autenshlyus N. V. Velikaya N. A. Varaksin M. Yu. Rukhavishnikov E. S. Mikhailova D. V. Morozov S. A. Fursov N. V. Agarina |
| author_sort | A. V. Sosnina |
| collection | DOAJ |
| description | Аbstract. The aim of present study was to investigate an influence of polyclonal activators upon cytokine-producing function of peripheral blood cells in the patients with colorectal adenocarcinomas. It was revealed that the stimulated production of IL-1β, IL-1ra, IL-2, IL-17, IL-18 and IFNγ by whole blood cells treated with polyclonal activators was significantly decreased in colorectal cancer patients, as compared to healthy individuals. The stimulated IL-1ra and IL-17 production was depressed during the tumor progression, along with increased release of TNFα and IL-8. It was found that the stimulation index of polyclonal activators upon production of IL-17 by whole blood cells (i.e., a cytokine production ratio of stimulated versus resting cells) may be used as a reliable pre-surgery predictor of tumor invasion, the latter being an important histopathological parameter for clinical oncologists. (Med. Immunol., 2011, vol. 13, N 2-3, pp 197-204 |
| format | Article |
| id | doaj-art-3f70631f593e47abb394e9ed784d1edf |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-3f70631f593e47abb394e9ed784d1edf2025-08-20T03:37:46ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01132-319720410.15789/1563-0625-2011-2-3-197-204516CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTSA. V. Sosnina0A. I. Autenshlyus1N. V. VelikayaN. A. Varaksin2M. Yu. Rukhavishnikov3E. S. Mikhailova4D. V. Morozov5S. A. Fursov6N. V. Agarina7НИИ молекулярной биологии и биофизики СО РАМН, г. НовосибирскНИИ молекулярной биологии и биофизики СО РАМН, г. НовосибирскЗАО «Вектор-Бест», г. НовосибирскЗАО «Вектор-Бест», г. НовосибирскНИИ молекулярной биологии и биофизики СО РАМН, г. НовосибирскНИИ молекулярной биологии и биофизики СО РАМН, г. НовосибирскНовосибирский областной онкологический диспансер, г. НовосибирскНовосибирский областной онкологический диспансер, г. НовосибирскАbstract. The aim of present study was to investigate an influence of polyclonal activators upon cytokine-producing function of peripheral blood cells in the patients with colorectal adenocarcinomas. It was revealed that the stimulated production of IL-1β, IL-1ra, IL-2, IL-17, IL-18 and IFNγ by whole blood cells treated with polyclonal activators was significantly decreased in colorectal cancer patients, as compared to healthy individuals. The stimulated IL-1ra and IL-17 production was depressed during the tumor progression, along with increased release of TNFα and IL-8. It was found that the stimulation index of polyclonal activators upon production of IL-17 by whole blood cells (i.e., a cytokine production ratio of stimulated versus resting cells) may be used as a reliable pre-surgery predictor of tumor invasion, the latter being an important histopathological parameter for clinical oncologists. (Med. Immunol., 2011, vol. 13, N 2-3, pp 197-204https://www.mimmun.ru/mimmun/article/view/519cytokinespolyclonal activatorscolorectal cancera |
| spellingShingle | A. V. Sosnina A. I. Autenshlyus N. V. Velikaya N. A. Varaksin M. Yu. Rukhavishnikov E. S. Mikhailova D. V. Morozov S. A. Fursov N. V. Agarina CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS Медицинская иммунология cytokines polyclonal activators colorectal cancera |
| title | CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS |
| title_full | CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS |
| title_fullStr | CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS |
| title_full_unstemmed | CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS |
| title_short | CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS |
| title_sort | cytokine producing function of peripheral blood cells in colorectal cancer patients |
| topic | cytokines polyclonal activators colorectal cancera |
| url | https://www.mimmun.ru/mimmun/article/view/519 |
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