Metabolic interplay between endometrial cancer and tumor-associated macrophages: lactate-induced M2 polarization enhances tumor progression

Metabolic interplay between endometrial cancer and tumor-associated macrophages: lactate-induced M2 polarization enhances tumor progression

Abstract Tumor-associated macrophages (TAMs), abundant within the tumor microenvironment, are key mediators of immunosuppression and represent promising therapeutic targets. Metabolic crosstalk between tumor cells and TAMs is a critical regulator of immune phenotype switching. However, the interacti...

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Bibliographic Details
Main Authors: Xiaodie Liu, Heming Sun, Jing Liang, Huan Yu, Ming Xue, Yuebo Li, Wenhui Li, Ying Xu, Bin Ling, Dingqing Feng
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Endometrial cancer
Tumor-associated macrophages
Metabolism reprogramming
Aerobic glycolysis
Lactate
Epithelial-mesenchymal transition
Online Access:https://doi.org/10.1186/s12967-025-06235-6
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https://doi.org/10.1186/s12967-025-06235-6

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