Cerebral inflammatory amyloid angiopathy: response to treatment
ABSTRACT Cerebral Amyloid Angiopathy (CAA) is a small vessel disease associated with β-amyloid (Aβ) deposition in cortical and leptomeningeal vessels. Traditionally diagnosed through invasive methods, it can now be identified via advanced imaging modalities, enhancing non-invasive diagnostic accurac...
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| Format: | Article |
| Language: | English |
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Associação Neurologia Cognitiva e do Comportamento
2025-08-01
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| Series: | Dementia & Neuropsychologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642025000100803&lng=en&tlng=en |
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| _version_ | 1849329488635101184 |
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| author | João Roberto Ribeiro Pimenta Júlian Letícia Freitas Maria Sheila Guimarães Rocha Sonia Maria Dozzi Brucki |
| author_facet | João Roberto Ribeiro Pimenta Júlian Letícia Freitas Maria Sheila Guimarães Rocha Sonia Maria Dozzi Brucki |
| author_sort | João Roberto Ribeiro Pimenta |
| collection | DOAJ |
| description | ABSTRACT Cerebral Amyloid Angiopathy (CAA) is a small vessel disease associated with β-amyloid (Aβ) deposition in cortical and leptomeningeal vessels. Traditionally diagnosed through invasive methods, it can now be identified via advanced imaging modalities, enhancing non-invasive diagnostic accuracy. A subset of patients exhibits an inflammatory presentation, termed Inflammatory Cerebral Amyloid Angiopathy (CAA-RI), characterized by cognitive decline, behavioral changes, and neurological deficits. This study highlighted two cases of CAA-RI with subacute onset, detailed clinical progression, and distinct MRI findings consistent with revised diagnostic criteria, enabling early suspicion. Both cases showed significant improvement with immunosuppressive therapy, reinforcing the potentially reversible nature of CAA-RI and the importance of early recognition. This article underscores the relevance of advanced imaging in the differential diagnosis of CAA and the potential for improved patient outcomes with timely treatment. |
| format | Article |
| id | doaj-art-3f5d8bc7e0fe4f16befc4ae13f7b6ecc |
| institution | Kabale University |
| issn | 1980-5764 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| record_format | Article |
| series | Dementia & Neuropsychologia |
| spelling | doaj-art-3f5d8bc7e0fe4f16befc4ae13f7b6ecc2025-08-20T03:47:16ZengAssociação Neurologia Cognitiva e do ComportamentoDementia & Neuropsychologia1980-57642025-08-011910.1590/1980-5764-dn-2024-0263Cerebral inflammatory amyloid angiopathy: response to treatmentJoão Roberto Ribeiro Pimentahttps://orcid.org/0000-0003-2609-2890Júlian Letícia Freitashttps://orcid.org/0000-0002-7119-3423Maria Sheila Guimarães Rochahttps://orcid.org/0000-0003-4312-3994Sonia Maria Dozzi Bruckihttps://orcid.org/0000-0002-8303-6732ABSTRACT Cerebral Amyloid Angiopathy (CAA) is a small vessel disease associated with β-amyloid (Aβ) deposition in cortical and leptomeningeal vessels. Traditionally diagnosed through invasive methods, it can now be identified via advanced imaging modalities, enhancing non-invasive diagnostic accuracy. A subset of patients exhibits an inflammatory presentation, termed Inflammatory Cerebral Amyloid Angiopathy (CAA-RI), characterized by cognitive decline, behavioral changes, and neurological deficits. This study highlighted two cases of CAA-RI with subacute onset, detailed clinical progression, and distinct MRI findings consistent with revised diagnostic criteria, enabling early suspicion. Both cases showed significant improvement with immunosuppressive therapy, reinforcing the potentially reversible nature of CAA-RI and the importance of early recognition. This article underscores the relevance of advanced imaging in the differential diagnosis of CAA and the potential for improved patient outcomes with timely treatment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642025000100803&lng=en&tlng=enCerebral Amyloid AngiopathyAmyloid Beta-PeptidesImmunosuppression TherapyMagnetic Resonance Imaging |
| spellingShingle | João Roberto Ribeiro Pimenta Júlian Letícia Freitas Maria Sheila Guimarães Rocha Sonia Maria Dozzi Brucki Cerebral inflammatory amyloid angiopathy: response to treatment Dementia & Neuropsychologia Cerebral Amyloid Angiopathy Amyloid Beta-Peptides Immunosuppression Therapy Magnetic Resonance Imaging |
| title | Cerebral inflammatory amyloid angiopathy: response to treatment |
| title_full | Cerebral inflammatory amyloid angiopathy: response to treatment |
| title_fullStr | Cerebral inflammatory amyloid angiopathy: response to treatment |
| title_full_unstemmed | Cerebral inflammatory amyloid angiopathy: response to treatment |
| title_short | Cerebral inflammatory amyloid angiopathy: response to treatment |
| title_sort | cerebral inflammatory amyloid angiopathy response to treatment |
| topic | Cerebral Amyloid Angiopathy Amyloid Beta-Peptides Immunosuppression Therapy Magnetic Resonance Imaging |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642025000100803&lng=en&tlng=en |
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