Sodium dichloroisocyanurate: a promising candidate for the disinfection of resilient drain biofilm
Summary: Background: Biofilms are complex multicellular communities of microorganisms embedded within a protective matrix which confers resistance to various antimicrobials, including biocides. Biofilms can cause a range of human diseases and are responsible for 1.7 million hospital-acquired infect...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
|
| Series: | Infection Prevention in Practice |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590088925000101 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823864229696897024 |
|---|---|
| author | Abbie Martin Natasha Doyle Tom F. O'Mahony |
| author_facet | Abbie Martin Natasha Doyle Tom F. O'Mahony |
| author_sort | Abbie Martin |
| collection | DOAJ |
| description | Summary: Background: Biofilms are complex multicellular communities of microorganisms embedded within a protective matrix which confers resistance to various antimicrobials, including biocides. Biofilms can cause a range of human diseases and are responsible for 1.7 million hospital-acquired infections in the US annually, providing an economic burden of $11.5 billion in treatment costs. Biofilm contained within drain and plumbing systems may contain pathogenic viruses and bacteria which pose a significant risk to patient safety within healthcare environments. Aim: The aim of this study was to determine if three hospital-grade disinfectants (sodium dichloroisocyanurate, peracetic acid and sodium hypochlorite) were capable of killing microorganisms within biofilm, and thus, determining their potential as candidates for drain biofilm disinfection. Methods: Pseudomonas aeruginosa biofilms were cultivated using the CDC biofilm reactor, a standardised method for determining disinfectant efficacy against biofilm within the United States of America. Each disinfectant was tested using a one-minute contact time, using the highest concentration available on the product label. Findings: The sodium dichloroisocyanurate product was successful in killing biofilm microorganisms, resulting in a log reduction of ≥ 8.70. Peracetic acid reduced biofilm by 3.82 log10 units, followed by sodium hypochlorite, which produced a reduction of 3.78 log10 units. Conclusions: The use of a highly effective disinfectant with proven biofilm efficacy can help ensure patient safety and reduce infection levels. Drains and plumbing systems provide a reservoir for potential pathogens and biofilm; thus, drain disinfection is critical in reducing the instance of hospital-acquired infections. Sodium dichloroisocyanurate may provide a reliable solution for drain applications and subsequently, patient wellbeing and safety. |
| format | Article |
| id | doaj-art-3f525b90c77349c598582d462e0eb96f |
| institution | Kabale University |
| issn | 2590-0889 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Infection Prevention in Practice |
| spelling | doaj-art-3f525b90c77349c598582d462e0eb96f2025-02-09T05:01:03ZengElsevierInfection Prevention in Practice2590-08892025-03-0171100446Sodium dichloroisocyanurate: a promising candidate for the disinfection of resilient drain biofilmAbbie Martin0Natasha Doyle1Tom F. O'Mahony2Microbiology & Validation Technician, R&D Department, Kersia Healthcare, Wexford, IrelandPrincipal R&D Scientist, R&D Department, Kersia Healthcare, Wexford, Ireland; Corresponding author. Address: Principal R&D Scientist, R&D Department, Kersia Healthcare, Wexford, Ireland.R&D Manager Healthcare, R&D Department, Kersia Healthcare, Wexford, IrelandSummary: Background: Biofilms are complex multicellular communities of microorganisms embedded within a protective matrix which confers resistance to various antimicrobials, including biocides. Biofilms can cause a range of human diseases and are responsible for 1.7 million hospital-acquired infections in the US annually, providing an economic burden of $11.5 billion in treatment costs. Biofilm contained within drain and plumbing systems may contain pathogenic viruses and bacteria which pose a significant risk to patient safety within healthcare environments. Aim: The aim of this study was to determine if three hospital-grade disinfectants (sodium dichloroisocyanurate, peracetic acid and sodium hypochlorite) were capable of killing microorganisms within biofilm, and thus, determining their potential as candidates for drain biofilm disinfection. Methods: Pseudomonas aeruginosa biofilms were cultivated using the CDC biofilm reactor, a standardised method for determining disinfectant efficacy against biofilm within the United States of America. Each disinfectant was tested using a one-minute contact time, using the highest concentration available on the product label. Findings: The sodium dichloroisocyanurate product was successful in killing biofilm microorganisms, resulting in a log reduction of ≥ 8.70. Peracetic acid reduced biofilm by 3.82 log10 units, followed by sodium hypochlorite, which produced a reduction of 3.78 log10 units. Conclusions: The use of a highly effective disinfectant with proven biofilm efficacy can help ensure patient safety and reduce infection levels. Drains and plumbing systems provide a reservoir for potential pathogens and biofilm; thus, drain disinfection is critical in reducing the instance of hospital-acquired infections. Sodium dichloroisocyanurate may provide a reliable solution for drain applications and subsequently, patient wellbeing and safety.http://www.sciencedirect.com/science/article/pii/S2590088925000101Infection preventionSodium dichloroisocyanurateBiofilmDrainsDisinfectantsHealthcare associated infections |
| spellingShingle | Abbie Martin Natasha Doyle Tom F. O'Mahony Sodium dichloroisocyanurate: a promising candidate for the disinfection of resilient drain biofilm Infection Prevention in Practice Infection prevention Sodium dichloroisocyanurate Biofilm Drains Disinfectants Healthcare associated infections |
| title | Sodium dichloroisocyanurate: a promising candidate for the disinfection of resilient drain biofilm |
| title_full | Sodium dichloroisocyanurate: a promising candidate for the disinfection of resilient drain biofilm |
| title_fullStr | Sodium dichloroisocyanurate: a promising candidate for the disinfection of resilient drain biofilm |
| title_full_unstemmed | Sodium dichloroisocyanurate: a promising candidate for the disinfection of resilient drain biofilm |
| title_short | Sodium dichloroisocyanurate: a promising candidate for the disinfection of resilient drain biofilm |
| title_sort | sodium dichloroisocyanurate a promising candidate for the disinfection of resilient drain biofilm |
| topic | Infection prevention Sodium dichloroisocyanurate Biofilm Drains Disinfectants Healthcare associated infections |
| url | http://www.sciencedirect.com/science/article/pii/S2590088925000101 |
| work_keys_str_mv | AT abbiemartin sodiumdichloroisocyanurateapromisingcandidateforthedisinfectionofresilientdrainbiofilm AT natashadoyle sodiumdichloroisocyanurateapromisingcandidateforthedisinfectionofresilientdrainbiofilm AT tomfomahony sodiumdichloroisocyanurateapromisingcandidateforthedisinfectionofresilientdrainbiofilm |