Association of DHEAS levels with COVID19 severity, gender, age, comorbidities, and management strategies
Abstract COVID-19 has globally impacted millions. This study investigates DHEAS (dehydroepiandrosterone sulfate) as a factor for COVID-19 progression, analyzing its relationship with disease status, temporal patterns, age, gender, and comorbidities to improve outcomes. DHEAS was quantified with a co...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-05919-9 |
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| author | Tahereh Jamali Sussan Kaboudanian Ardestani Mohammad-Reza Vaez-Mahdavi Arezou Rezaei Mohammad Mehdi Naghizadeh Fatemeh Tuserkani HosseinAli Khazaei Ali Khodadadi Bahman Khazaei Keivan Latifi Tooba Ghazanfari |
| author_facet | Tahereh Jamali Sussan Kaboudanian Ardestani Mohammad-Reza Vaez-Mahdavi Arezou Rezaei Mohammad Mehdi Naghizadeh Fatemeh Tuserkani HosseinAli Khazaei Ali Khodadadi Bahman Khazaei Keivan Latifi Tooba Ghazanfari |
| author_sort | Tahereh Jamali |
| collection | DOAJ |
| description | Abstract COVID-19 has globally impacted millions. This study investigates DHEAS (dehydroepiandrosterone sulfate) as a factor for COVID-19 progression, analyzing its relationship with disease status, temporal patterns, age, gender, and comorbidities to improve outcomes. DHEAS was quantified with a competitive chemiluminescent immunoassay. We conducted DHEAS analysis across different days. COVID-19 patients, particularly inpatients, have lower DHEAS levels compared to controls. DHEAS levels in COVID-19 patients showed a dynamic pattern, with an initial decline followed by recovery. The scatter plot analysis suggested COVID-19 could increase the age-related decline in DHEAS among males. Comorbidities, including hypertension, heart disease, and diabetes mellitus, were prevalent among COVID-19 patients and correlated with disease severity. Hypertension moderated the relationship between hospitalization and DHEAS, especially in females. Our findings showed a significant association between lower DHEAS and COVID-19 severity, along with temporal dynamics. COVID-19’s potential to increase the age-related decline in DHEAS, especially in males, underscores its intricate relationship with age. Hypertension’s influence on DHEAS suggests a gender-specific effect, emphasizing tailored management approaches. These findings offer valuable insights into the interaction between COVID-19, hormonal dynamics, and demographic factors, suggesting that DHEAS levels may play a role in the pathophysiology of the disease and could be considered alongside other markers. |
| format | Article |
| id | doaj-art-3f4f13e645734d70837fe2caabdcd17c |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-3f4f13e645734d70837fe2caabdcd17c2025-08-20T03:03:40ZengNature PortfolioScientific Reports2045-23222025-07-0115111410.1038/s41598-025-05919-9Association of DHEAS levels with COVID19 severity, gender, age, comorbidities, and management strategiesTahereh Jamali0Sussan Kaboudanian Ardestani1Mohammad-Reza Vaez-Mahdavi2Arezou Rezaei3Mohammad Mehdi Naghizadeh4Fatemeh Tuserkani5HosseinAli Khazaei6Ali Khodadadi7Bahman Khazaei8Keivan Latifi9Tooba Ghazanfari10Immunoregulation Research Center, Shahed UniversityInstitute of Biochemistry and Biophysics, University of TehranDepartment of Health Equity, Immunoregulation Research Center, Shahed UniversitySchool of Biological Science, Damghan UniversityNon Communicable Diseases Research Center, Fasa University of Medical ScienceImmunoregulation Research Center, Shahed UniversityClinical Immunology Research Center (CIRC) of Zahedan, University of Medical SciencesDepartment of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical SciencesClinical Immunology Research Center (CIRC) of Zahedan, University of Medical Sciences10- Critical Care Medicine, Department of Anesthesiology, School of Allied Medical Sciences, Mazandaran University of Medical ScienceImmunoregulation Research Center, Shahed UniversityAbstract COVID-19 has globally impacted millions. This study investigates DHEAS (dehydroepiandrosterone sulfate) as a factor for COVID-19 progression, analyzing its relationship with disease status, temporal patterns, age, gender, and comorbidities to improve outcomes. DHEAS was quantified with a competitive chemiluminescent immunoassay. We conducted DHEAS analysis across different days. COVID-19 patients, particularly inpatients, have lower DHEAS levels compared to controls. DHEAS levels in COVID-19 patients showed a dynamic pattern, with an initial decline followed by recovery. The scatter plot analysis suggested COVID-19 could increase the age-related decline in DHEAS among males. Comorbidities, including hypertension, heart disease, and diabetes mellitus, were prevalent among COVID-19 patients and correlated with disease severity. Hypertension moderated the relationship between hospitalization and DHEAS, especially in females. Our findings showed a significant association between lower DHEAS and COVID-19 severity, along with temporal dynamics. COVID-19’s potential to increase the age-related decline in DHEAS, especially in males, underscores its intricate relationship with age. Hypertension’s influence on DHEAS suggests a gender-specific effect, emphasizing tailored management approaches. These findings offer valuable insights into the interaction between COVID-19, hormonal dynamics, and demographic factors, suggesting that DHEAS levels may play a role in the pathophysiology of the disease and could be considered alongside other markers.https://doi.org/10.1038/s41598-025-05919-9COVID-19DHEASInpatientsOutpatientsComorbidity diseases |
| spellingShingle | Tahereh Jamali Sussan Kaboudanian Ardestani Mohammad-Reza Vaez-Mahdavi Arezou Rezaei Mohammad Mehdi Naghizadeh Fatemeh Tuserkani HosseinAli Khazaei Ali Khodadadi Bahman Khazaei Keivan Latifi Tooba Ghazanfari Association of DHEAS levels with COVID19 severity, gender, age, comorbidities, and management strategies Scientific Reports COVID-19 DHEAS Inpatients Outpatients Comorbidity diseases |
| title | Association of DHEAS levels with COVID19 severity, gender, age, comorbidities, and management strategies |
| title_full | Association of DHEAS levels with COVID19 severity, gender, age, comorbidities, and management strategies |
| title_fullStr | Association of DHEAS levels with COVID19 severity, gender, age, comorbidities, and management strategies |
| title_full_unstemmed | Association of DHEAS levels with COVID19 severity, gender, age, comorbidities, and management strategies |
| title_short | Association of DHEAS levels with COVID19 severity, gender, age, comorbidities, and management strategies |
| title_sort | association of dheas levels with covid19 severity gender age comorbidities and management strategies |
| topic | COVID-19 DHEAS Inpatients Outpatients Comorbidity diseases |
| url | https://doi.org/10.1038/s41598-025-05919-9 |
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