Diagnosis of secondary tuberculosis infection in an asymptomatic elderly with cancer using next-generation sequencing: Case report
In recent years, there has been a notable increase in the prevalence of tumors and tuberculosis (TB), particularly among elderly and immunocompromised populations. Early diagnosis and treatment are crucial for significantly improving patient outcomes. However, traditional diagnostic methods exhibit...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-06-01
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| Series: | Open Life Sciences |
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| Online Access: | https://doi.org/10.1515/biol-2025-1123 |
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| author | Huang Jiahuan Ren Wenbo Hu Weishang Ni Jianfang |
| author_facet | Huang Jiahuan Ren Wenbo Hu Weishang Ni Jianfang |
| author_sort | Huang Jiahuan |
| collection | DOAJ |
| description | In recent years, there has been a notable increase in the prevalence of tumors and tuberculosis (TB), particularly among elderly and immunocompromised populations. Early diagnosis and treatment are crucial for significantly improving patient outcomes. However, traditional diagnostic methods exhibit certain limitations. The rapid advancement of metagenomic next-generation sequencing (mNGS) has shown promising applications in the field of infectious diseases. We describe an 88-year-old male with multiple comorbidities, including newly diagnosed localized prostate cancer, who presented asymptomatically. Routine mNGS screening unexpectedly identified Mycobacterium tuberculosis, suggesting that malignancy may foster immune conditions favoring latent TB reactivation. This case emphasizes mNGS’s role as a rapid, sensitive diagnostic adjunct for occult infections in high-risk populations. |
| format | Article |
| id | doaj-art-3f462df3c03b40cea8f6591e5e700410 |
| institution | Kabale University |
| issn | 2391-5412 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj-art-3f462df3c03b40cea8f6591e5e7004102025-08-20T03:47:20ZengDe GruyterOpen Life Sciences2391-54122025-06-0120152028010.1515/biol-2025-1123Diagnosis of secondary tuberculosis infection in an asymptomatic elderly with cancer using next-generation sequencing: Case reportHuang Jiahuan0Ren Wenbo1Hu Weishang2Ni Jianfang3Geriatric Medicine Center, Department of Geriatric Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaCenter for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaGeriatric Medicine Center, Department No. 2 of Acupuncture & Massage, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaGeriatric Medicine Center, Department of Geriatric Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaIn recent years, there has been a notable increase in the prevalence of tumors and tuberculosis (TB), particularly among elderly and immunocompromised populations. Early diagnosis and treatment are crucial for significantly improving patient outcomes. However, traditional diagnostic methods exhibit certain limitations. The rapid advancement of metagenomic next-generation sequencing (mNGS) has shown promising applications in the field of infectious diseases. We describe an 88-year-old male with multiple comorbidities, including newly diagnosed localized prostate cancer, who presented asymptomatically. Routine mNGS screening unexpectedly identified Mycobacterium tuberculosis, suggesting that malignancy may foster immune conditions favoring latent TB reactivation. This case emphasizes mNGS’s role as a rapid, sensitive diagnostic adjunct for occult infections in high-risk populations.https://doi.org/10.1515/biol-2025-1123metagenomic next-generation sequencingmycobacterium tuberculosiscancerelderly |
| spellingShingle | Huang Jiahuan Ren Wenbo Hu Weishang Ni Jianfang Diagnosis of secondary tuberculosis infection in an asymptomatic elderly with cancer using next-generation sequencing: Case report Open Life Sciences metagenomic next-generation sequencing mycobacterium tuberculosis cancer elderly |
| title | Diagnosis of secondary tuberculosis infection in an asymptomatic elderly with cancer using next-generation sequencing: Case report |
| title_full | Diagnosis of secondary tuberculosis infection in an asymptomatic elderly with cancer using next-generation sequencing: Case report |
| title_fullStr | Diagnosis of secondary tuberculosis infection in an asymptomatic elderly with cancer using next-generation sequencing: Case report |
| title_full_unstemmed | Diagnosis of secondary tuberculosis infection in an asymptomatic elderly with cancer using next-generation sequencing: Case report |
| title_short | Diagnosis of secondary tuberculosis infection in an asymptomatic elderly with cancer using next-generation sequencing: Case report |
| title_sort | diagnosis of secondary tuberculosis infection in an asymptomatic elderly with cancer using next generation sequencing case report |
| topic | metagenomic next-generation sequencing mycobacterium tuberculosis cancer elderly |
| url | https://doi.org/10.1515/biol-2025-1123 |
| work_keys_str_mv | AT huangjiahuan diagnosisofsecondarytuberculosisinfectioninanasymptomaticelderlywithcancerusingnextgenerationsequencingcasereport AT renwenbo diagnosisofsecondarytuberculosisinfectioninanasymptomaticelderlywithcancerusingnextgenerationsequencingcasereport AT huweishang diagnosisofsecondarytuberculosisinfectioninanasymptomaticelderlywithcancerusingnextgenerationsequencingcasereport AT nijianfang diagnosisofsecondarytuberculosisinfectioninanasymptomaticelderlywithcancerusingnextgenerationsequencingcasereport |