Role of microbiota in pain: From bench to bedside
Abstract Interactions between the microbiota and host have been proven to be critical regulators of homeostasis, and pain perception is no exception. Emerging evidence has identified the mechanisms by which microbiota dysbiosis contributes to hyperalgesia and revealed the potential value of microbio...
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| Format: | Article |
| Language: | English |
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Wiley
2025-03-01
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| Series: | iMetaOmics |
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| Online Access: | https://doi.org/10.1002/imo2.58 |
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| _version_ | 1849715786242850816 |
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| author | Huiguang Ren Bo Cao Qixuan Xu Ruiyang Zhao Hanghang Li Bo Wei |
| author_facet | Huiguang Ren Bo Cao Qixuan Xu Ruiyang Zhao Hanghang Li Bo Wei |
| author_sort | Huiguang Ren |
| collection | DOAJ |
| description | Abstract Interactions between the microbiota and host have been proven to be critical regulators of homeostasis, and pain perception is no exception. Emerging evidence has identified the mechanisms by which microbiota dysbiosis contributes to hyperalgesia and revealed the potential value of microbiota‐associated therapies in pain management. Herein, the authors introduce the basic knowledge of pain and microbiota for readers who are not simultaneously majoring in these two fields. The clarified mechanisms underlying the regulation of pain by the microbiota are outlined in terms of three ways. This review summarizes the current advancements in pain management and microbiology research for clinicians who wish to focus on this area. Probiotics, fecal microbiota transplantation, and other methods of microbiota modulation for pain management have entered clinical translation. The authors further propose the present limitations and prospects for high‐quality development of preclinical and clinical investigations. Importantly, despite the large amount of attention given to gut bacteria, this review also puts forward great expectations on the role of nongut and nonbacterial microbiota in pain sensation. Efforts to decipher the mechanisms of microbiota functions will help to promote achievements in pain management from bench to bedside. |
| format | Article |
| id | doaj-art-3f45b6d143504bf9ab7031a0b461ffdf |
| institution | DOAJ |
| issn | 2996-9506 2996-9514 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | iMetaOmics |
| spelling | doaj-art-3f45b6d143504bf9ab7031a0b461ffdf2025-08-20T03:13:12ZengWileyiMetaOmics2996-95062996-95142025-03-0121n/an/a10.1002/imo2.58Role of microbiota in pain: From bench to bedsideHuiguang Ren0Bo Cao1Qixuan Xu2Ruiyang Zhao3Hanghang Li4Bo Wei5Department of General Surgery, First Medical Center Chinese PLA General Hospital Beijing ChinaDepartment of General Surgery, First Medical Center Chinese PLA General Hospital Beijing ChinaDepartment of General Surgery, First Medical Center Chinese PLA General Hospital Beijing ChinaDepartment of General Surgery, First Medical Center Chinese PLA General Hospital Beijing ChinaDepartment of General Surgery, First Medical Center Chinese PLA General Hospital Beijing ChinaDepartment of General Surgery, First Medical Center Chinese PLA General Hospital Beijing ChinaAbstract Interactions between the microbiota and host have been proven to be critical regulators of homeostasis, and pain perception is no exception. Emerging evidence has identified the mechanisms by which microbiota dysbiosis contributes to hyperalgesia and revealed the potential value of microbiota‐associated therapies in pain management. Herein, the authors introduce the basic knowledge of pain and microbiota for readers who are not simultaneously majoring in these two fields. The clarified mechanisms underlying the regulation of pain by the microbiota are outlined in terms of three ways. This review summarizes the current advancements in pain management and microbiology research for clinicians who wish to focus on this area. Probiotics, fecal microbiota transplantation, and other methods of microbiota modulation for pain management have entered clinical translation. The authors further propose the present limitations and prospects for high‐quality development of preclinical and clinical investigations. Importantly, despite the large amount of attention given to gut bacteria, this review also puts forward great expectations on the role of nongut and nonbacterial microbiota in pain sensation. Efforts to decipher the mechanisms of microbiota functions will help to promote achievements in pain management from bench to bedside.https://doi.org/10.1002/imo2.58fecal microbiota transplantationmicrobiotaneural circuitpainprobiotics |
| spellingShingle | Huiguang Ren Bo Cao Qixuan Xu Ruiyang Zhao Hanghang Li Bo Wei Role of microbiota in pain: From bench to bedside iMetaOmics fecal microbiota transplantation microbiota neural circuit pain probiotics |
| title | Role of microbiota in pain: From bench to bedside |
| title_full | Role of microbiota in pain: From bench to bedside |
| title_fullStr | Role of microbiota in pain: From bench to bedside |
| title_full_unstemmed | Role of microbiota in pain: From bench to bedside |
| title_short | Role of microbiota in pain: From bench to bedside |
| title_sort | role of microbiota in pain from bench to bedside |
| topic | fecal microbiota transplantation microbiota neural circuit pain probiotics |
| url | https://doi.org/10.1002/imo2.58 |
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