Classical Paal-Knorr Cyclization for Synthesis of Pyrrole-Based Aryl Hydrazones and In Vitro/In Vivo Evaluation on Pharmacological Models of Parkinson’s Disease

Classical Paal-Knorr Cyclization for Synthesis of Pyrrole-Based Aryl Hydrazones and In Vitro/In Vivo Evaluation on Pharmacological Models of Parkinson’s Disease

Some studies performed in our laboratory on pyrrole and its derivatives pointed towards the enrichment of the evaluations of these promising chemical structures for the potential treatment of neurodegenerative conditions in general and Parkinson’s disease in particular. A classical Paal-Knorr cycliz...

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Bibliographic Details
Main Authors: Maya Georgieva, Martin Sharkov, Emilio Mateev, Diana Tzankova, Georgi Popov, Vasil Manov, Alexander Zlatkov, Rumyana Simeonova, Magdalena Kondeva-Burdina
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
synthesis
pyrrole
hydrazone
in vivo
Parkinson’s
Online Access:https://www.mdpi.com/1420-3049/30/15/3154
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