The Protective Effects of Ultraviolet A1 Irradiation on Spontaneous Lupus Erythematosus-Like Skin Lesions in MRL/lpr Mice
We investigated the effects of ultraviolet A1 (UVA1) irradiation on spontaneous lupus erythematosus- (LE-) like skin lesions of MRL/lpr mice, using a disease prevention model. UVA1 irradiation significantly inhibited the development of LE-like skin lesions, without obvious changes of the disease inc...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2009/673952 |
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| author | Naoya Mikita Nobuo Kanazawa Takashi Yoshimasu Takaharu Ikeda Hong-jin Li Yuki Yamamoto Fukumi Furukawa |
| author_facet | Naoya Mikita Nobuo Kanazawa Takashi Yoshimasu Takaharu Ikeda Hong-jin Li Yuki Yamamoto Fukumi Furukawa |
| author_sort | Naoya Mikita |
| collection | DOAJ |
| description | We investigated the effects of ultraviolet A1 (UVA1) irradiation on spontaneous lupus erythematosus- (LE-) like skin lesions of MRL/lpr mice, using a disease prevention model. UVA1 irradiation significantly inhibited the development of LE-like skin lesions, without obvious changes of the disease including renal disease and serum antinuclear antibody levels. Besides the massive infiltration of mast cells in the LE-like skin lesions, in the nonlesional skins, more mast cells infiltrated in the UVA1-irradiated group compared with the nonirradiated group. Although apoptotic cells were remarkably seen in the dermis of UVA1-irradiated mice, those cells were hardly detectable in the dermis of the nonirradiated mice without skin lesions. Further analysis showed that some of those apoptotic cells were mast cells. Thus, UVA1 might exert its effects, at least in part, through the induction of the apoptosis of pathogenic mast cells. Our results supported the clinical efficacy of UVA1 irradiation for skin lesions of lupus patients. |
| format | Article |
| id | doaj-art-3f3ed8787f584b9f829135f4f8d4ddb4 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-3f3ed8787f584b9f829135f4f8d4ddb42025-08-20T03:35:51ZengWileyClinical and Developmental Immunology1740-25221740-25302009-01-01200910.1155/2009/673952673952The Protective Effects of Ultraviolet A1 Irradiation on Spontaneous Lupus Erythematosus-Like Skin Lesions in MRL/lpr MiceNaoya Mikita0Nobuo Kanazawa1Takashi Yoshimasu2Takaharu Ikeda3Hong-jin Li4Yuki Yamamoto5Fukumi Furukawa6Department of Dermatology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, JapanDepartment of Dermatology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, JapanDepartment of Dermatology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, JapanDepartment of Dermatology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, JapanDepartment of Dermatology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, JapanDepartment of Dermatology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, JapanDepartment of Dermatology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, JapanWe investigated the effects of ultraviolet A1 (UVA1) irradiation on spontaneous lupus erythematosus- (LE-) like skin lesions of MRL/lpr mice, using a disease prevention model. UVA1 irradiation significantly inhibited the development of LE-like skin lesions, without obvious changes of the disease including renal disease and serum antinuclear antibody levels. Besides the massive infiltration of mast cells in the LE-like skin lesions, in the nonlesional skins, more mast cells infiltrated in the UVA1-irradiated group compared with the nonirradiated group. Although apoptotic cells were remarkably seen in the dermis of UVA1-irradiated mice, those cells were hardly detectable in the dermis of the nonirradiated mice without skin lesions. Further analysis showed that some of those apoptotic cells were mast cells. Thus, UVA1 might exert its effects, at least in part, through the induction of the apoptosis of pathogenic mast cells. Our results supported the clinical efficacy of UVA1 irradiation for skin lesions of lupus patients.http://dx.doi.org/10.1155/2009/673952 |
| spellingShingle | Naoya Mikita Nobuo Kanazawa Takashi Yoshimasu Takaharu Ikeda Hong-jin Li Yuki Yamamoto Fukumi Furukawa The Protective Effects of Ultraviolet A1 Irradiation on Spontaneous Lupus Erythematosus-Like Skin Lesions in MRL/lpr Mice Clinical and Developmental Immunology |
| title | The Protective Effects of Ultraviolet A1 Irradiation on Spontaneous Lupus Erythematosus-Like Skin Lesions in MRL/lpr Mice |
| title_full | The Protective Effects of Ultraviolet A1 Irradiation on Spontaneous Lupus Erythematosus-Like Skin Lesions in MRL/lpr Mice |
| title_fullStr | The Protective Effects of Ultraviolet A1 Irradiation on Spontaneous Lupus Erythematosus-Like Skin Lesions in MRL/lpr Mice |
| title_full_unstemmed | The Protective Effects of Ultraviolet A1 Irradiation on Spontaneous Lupus Erythematosus-Like Skin Lesions in MRL/lpr Mice |
| title_short | The Protective Effects of Ultraviolet A1 Irradiation on Spontaneous Lupus Erythematosus-Like Skin Lesions in MRL/lpr Mice |
| title_sort | protective effects of ultraviolet a1 irradiation on spontaneous lupus erythematosus like skin lesions in mrl lpr mice |
| url | http://dx.doi.org/10.1155/2009/673952 |
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