Severe angiostrongyliasis with neuropsychiatric symptoms in vulnerable adults: Early diagnosis via next-generation sequencing and successful treatment
Angiostrongylus cantonensis (AC) is a parasite that occasionally infects humans, causing eosinophilic meningitis (EM). In this study, we identified two adult males with severe angiostrongyliasis being treated at the ICU. Both presented with mental and behavioral abnormalities and were initially trea...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Journal of Infection and Public Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S187603412500108X |
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| author | Xiaomiao Tang Juanjuan Wu Yefeng Yang Yingqiong Wang Chengji Jin Chengzhi Xie Mei Wang Run Liu Xiaozhi Wang Fengyun Wang Jing Wang |
| author_facet | Xiaomiao Tang Juanjuan Wu Yefeng Yang Yingqiong Wang Chengji Jin Chengzhi Xie Mei Wang Run Liu Xiaozhi Wang Fengyun Wang Jing Wang |
| author_sort | Xiaomiao Tang |
| collection | DOAJ |
| description | Angiostrongylus cantonensis (AC) is a parasite that occasionally infects humans, causing eosinophilic meningitis (EM). In this study, we identified two adult males with severe angiostrongyliasis being treated at the ICU. Both presented with mental and behavioral abnormalities and were initially treated for psychiatric disorders before showing symptoms like cough, fever, and altered consciousness. Patient 1, a homeless individual, presented with elevated eosinophil levels and typical meningitis symptoms, prompting an early diagnosis of EM that was later confirmed via next-generation sequencing (NGS) of the cerebrospinal fluid. Patient 2, who had schizophrenia as a pre-existing condition, did not exhibit the typical signs of meningitis but was nonetheless detected via NGS. Both patients responded well to corticosteroids and anthelmintics. A review of case reports underscores heightened infection risks among children with pica and vulnerable adults, including those with mental disorders or homelessness. The use of NGS is effective for the early diagnosis and treatment of severe angiostrongyliasis, especially in those with atypical symptoms. |
| format | Article |
| id | doaj-art-3f3eb67754504085b98ef818e9ffa02d |
| institution | DOAJ |
| issn | 1876-0341 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj-art-3f3eb67754504085b98ef818e9ffa02d2025-08-20T03:08:24ZengElsevierJournal of Infection and Public Health1876-03412025-05-0118510275910.1016/j.jiph.2025.102759Severe angiostrongyliasis with neuropsychiatric symptoms in vulnerable adults: Early diagnosis via next-generation sequencing and successful treatmentXiaomiao Tang0Juanjuan Wu1Yefeng Yang2Yingqiong Wang3Chengji Jin4Chengzhi Xie5Mei Wang6Run Liu7Xiaozhi Wang8Fengyun Wang9Jing Wang10Department of Respiratory Medicine, Second Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Respiratory Medicine, Second Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Respiratory Medicine, Second Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Respiratory Medicine, Second Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Respiratory Medicine, Second Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Critical Care Medicine, Second Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Critical Care Medicine, Second Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Critical Care Medicine, Second Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Critical Care Medicine, Second Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Critical Care Medicine, Second Affiliated Hospital of Hainan Medical University, Haikou, China; Correspondence to: No.368, Yihai Avenue, Longhua District, Haikou, Hainan Province, China.Department of Respiratory Medicine, Second Affiliated Hospital of Hainan Medical University, Haikou, China; NHC Key Laboratory of Tropical Disease Control, Hainan Medical University, Haikou, China; Correspondence to: No.368, Yihai Avenue, Longhua District, Haikou, Hainan Province, China.Angiostrongylus cantonensis (AC) is a parasite that occasionally infects humans, causing eosinophilic meningitis (EM). In this study, we identified two adult males with severe angiostrongyliasis being treated at the ICU. Both presented with mental and behavioral abnormalities and were initially treated for psychiatric disorders before showing symptoms like cough, fever, and altered consciousness. Patient 1, a homeless individual, presented with elevated eosinophil levels and typical meningitis symptoms, prompting an early diagnosis of EM that was later confirmed via next-generation sequencing (NGS) of the cerebrospinal fluid. Patient 2, who had schizophrenia as a pre-existing condition, did not exhibit the typical signs of meningitis but was nonetheless detected via NGS. Both patients responded well to corticosteroids and anthelmintics. A review of case reports underscores heightened infection risks among children with pica and vulnerable adults, including those with mental disorders or homelessness. The use of NGS is effective for the early diagnosis and treatment of severe angiostrongyliasis, especially in those with atypical symptoms.http://www.sciencedirect.com/science/article/pii/S187603412500108XAngiostrongyliasisEosinophilic meningitisEarly diagnosisNext-generation sequencingVulnerable groups |
| spellingShingle | Xiaomiao Tang Juanjuan Wu Yefeng Yang Yingqiong Wang Chengji Jin Chengzhi Xie Mei Wang Run Liu Xiaozhi Wang Fengyun Wang Jing Wang Severe angiostrongyliasis with neuropsychiatric symptoms in vulnerable adults: Early diagnosis via next-generation sequencing and successful treatment Journal of Infection and Public Health Angiostrongyliasis Eosinophilic meningitis Early diagnosis Next-generation sequencing Vulnerable groups |
| title | Severe angiostrongyliasis with neuropsychiatric symptoms in vulnerable adults: Early diagnosis via next-generation sequencing and successful treatment |
| title_full | Severe angiostrongyliasis with neuropsychiatric symptoms in vulnerable adults: Early diagnosis via next-generation sequencing and successful treatment |
| title_fullStr | Severe angiostrongyliasis with neuropsychiatric symptoms in vulnerable adults: Early diagnosis via next-generation sequencing and successful treatment |
| title_full_unstemmed | Severe angiostrongyliasis with neuropsychiatric symptoms in vulnerable adults: Early diagnosis via next-generation sequencing and successful treatment |
| title_short | Severe angiostrongyliasis with neuropsychiatric symptoms in vulnerable adults: Early diagnosis via next-generation sequencing and successful treatment |
| title_sort | severe angiostrongyliasis with neuropsychiatric symptoms in vulnerable adults early diagnosis via next generation sequencing and successful treatment |
| topic | Angiostrongyliasis Eosinophilic meningitis Early diagnosis Next-generation sequencing Vulnerable groups |
| url | http://www.sciencedirect.com/science/article/pii/S187603412500108X |
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