The Association Between the CALLY Index and All-Cause Mortality in Patients with COPD: Results from the Cohort Study of NHANES 2007–2010

Yu Ding,1 Yuxia Liu,2 Jianjian Yu,2 Chengsen Cai,2 Lina Fu,2 Jie Zhu,3 Shengzhen Yang,4 Yu Jiang,1 Jun Wang2 1The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, The Second Af...

Full description

Saved in:
Bibliographic Details
Main Authors: Ding Y, Liu Y, Yu J, Cai C, Fu L, Zhu J, Yang S, Jiang Y, Wang J
Format: Article
Language:English
Published: Dove Medical Press 2025-01-01
Series:International Journal of COPD
Subjects:
Online Access:https://www.dovepress.com/the-association-between-the-cally-index-and-all-cause-mortality-in-pat-peer-reviewed-fulltext-article-COPD
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832590386498895872
author Ding Y
Liu Y
Yu J
Cai C
Fu L
Zhu J
Yang S
Jiang Y
Wang J
author_facet Ding Y
Liu Y
Yu J
Cai C
Fu L
Zhu J
Yang S
Jiang Y
Wang J
author_sort Ding Y
collection DOAJ
description Yu Ding,1 Yuxia Liu,2 Jianjian Yu,2 Chengsen Cai,2 Lina Fu,2 Jie Zhu,3 Shengzhen Yang,4 Yu Jiang,1 Jun Wang2 1The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 3Department of Pharmacy, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 4Department of Pulmonary, Rizhao Hospital of Traditional Chinese Medicine, Rizhao, People’s Republic of ChinaCorrespondence: Jun Wang, Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China, Email jnwj660606@163.comPurpose: The C-reactive protein (CRP)–albumin–lymphocyte (CALLY) index is a newly developed biomarker that combines measurements of CRP, serum albumin, and lymphocyte count. This index provides a thorough assessment of a patient’s inflammation level, nutritional condition, and immunological function. The objective of this study is to examine the correlation between the CALLY index and all-cause mortality in COPD patients.Methods: We calculated the CALLY index using data from the National Health and Nutrition Examination Survey (NHANES) for the 2007– 2008 and 2009– 2010 cycles, extracted from the participants’ peripheral blood samples. The study utilized Kaplan-Meier curves, restricted cubic spline (RCS) curves, and Cox regression analysis to evaluate the relationship between the CALLY index and the risk of all-cause mortality in COPD patients. To assess the predictive accuracy of the CALLY index, we calculated the area under the receiver operating characteristic (ROC) curve (AUC).Results: The study included 1,048 participants and found a significant negative correlation between the CALLY index and all-cause mortality in patients with COPD. The CALLY index was a major predictor of survival in COPD patients [fully adjusted model: in the 3rd quartile, HR = 1.61, 95% CI: 1.02– 2.52, p = 0.039; in the 2nd quartile, HR = 2.11, 95% CI: 1.22– 3.65, p = 0.008; in the 1st quartile, HR = 3.12, 95% CI: 2.00– 4.85, p < 0.001]. The RCS curves demonstrated a non-linear association between the CALLY index and all-cause mortality in COPD patients. The areas under the curve (AUC) in predicting 5- and 10-year all-cause mortality were 0.693 and 0.656.Conclusion: The CALLY index has a strong relationship with all-cause mortality in patients with COPD in the US and could serve as a prognostic biomarker for these patients.Keywords: chronic obstructive pulmonary disease, the C-reactive protein–albumin–lymphocyte index, national health and nutrition examination survey, biomarker
format Article
id doaj-art-3f38a612d4d7482fbf16568cc1287963
institution Kabale University
issn 1178-2005
language English
publishDate 2025-01-01
publisher Dove Medical Press
record_format Article
series International Journal of COPD
spelling doaj-art-3f38a612d4d7482fbf16568cc12879632025-01-23T18:50:33ZengDove Medical PressInternational Journal of COPD1178-20052025-01-01Volume 2015916999504The Association Between the CALLY Index and All-Cause Mortality in Patients with COPD: Results from the Cohort Study of NHANES 2007&ndash;2010Ding YLiu YYu JCai CFu LZhu JYang SJiang YWang JYu Ding,1 Yuxia Liu,2 Jianjian Yu,2 Chengsen Cai,2 Lina Fu,2 Jie Zhu,3 Shengzhen Yang,4 Yu Jiang,1 Jun Wang2 1The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 3Department of Pharmacy, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 4Department of Pulmonary, Rizhao Hospital of Traditional Chinese Medicine, Rizhao, People’s Republic of ChinaCorrespondence: Jun Wang, Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China, Email jnwj660606@163.comPurpose: The C-reactive protein (CRP)–albumin–lymphocyte (CALLY) index is a newly developed biomarker that combines measurements of CRP, serum albumin, and lymphocyte count. This index provides a thorough assessment of a patient’s inflammation level, nutritional condition, and immunological function. The objective of this study is to examine the correlation between the CALLY index and all-cause mortality in COPD patients.Methods: We calculated the CALLY index using data from the National Health and Nutrition Examination Survey (NHANES) for the 2007– 2008 and 2009– 2010 cycles, extracted from the participants’ peripheral blood samples. The study utilized Kaplan-Meier curves, restricted cubic spline (RCS) curves, and Cox regression analysis to evaluate the relationship between the CALLY index and the risk of all-cause mortality in COPD patients. To assess the predictive accuracy of the CALLY index, we calculated the area under the receiver operating characteristic (ROC) curve (AUC).Results: The study included 1,048 participants and found a significant negative correlation between the CALLY index and all-cause mortality in patients with COPD. The CALLY index was a major predictor of survival in COPD patients [fully adjusted model: in the 3rd quartile, HR = 1.61, 95% CI: 1.02– 2.52, p = 0.039; in the 2nd quartile, HR = 2.11, 95% CI: 1.22– 3.65, p = 0.008; in the 1st quartile, HR = 3.12, 95% CI: 2.00– 4.85, p < 0.001]. The RCS curves demonstrated a non-linear association between the CALLY index and all-cause mortality in COPD patients. The areas under the curve (AUC) in predicting 5- and 10-year all-cause mortality were 0.693 and 0.656.Conclusion: The CALLY index has a strong relationship with all-cause mortality in patients with COPD in the US and could serve as a prognostic biomarker for these patients.Keywords: chronic obstructive pulmonary disease, the C-reactive protein–albumin–lymphocyte index, national health and nutrition examination survey, biomarkerhttps://www.dovepress.com/the-association-between-the-cally-index-and-all-cause-mortality-in-pat-peer-reviewed-fulltext-article-COPDchronic obstructive pulmonary diseasethe c-reactive protein–albumin–lymphocyte indexnational health and nutrition examination surveybiomarker.
spellingShingle Ding Y
Liu Y
Yu J
Cai C
Fu L
Zhu J
Yang S
Jiang Y
Wang J
The Association Between the CALLY Index and All-Cause Mortality in Patients with COPD: Results from the Cohort Study of NHANES 2007&ndash;2010
International Journal of COPD
chronic obstructive pulmonary disease
the c-reactive protein–albumin–lymphocyte index
national health and nutrition examination survey
biomarker.
title The Association Between the CALLY Index and All-Cause Mortality in Patients with COPD: Results from the Cohort Study of NHANES 2007&ndash;2010
title_full The Association Between the CALLY Index and All-Cause Mortality in Patients with COPD: Results from the Cohort Study of NHANES 2007&ndash;2010
title_fullStr The Association Between the CALLY Index and All-Cause Mortality in Patients with COPD: Results from the Cohort Study of NHANES 2007&ndash;2010
title_full_unstemmed The Association Between the CALLY Index and All-Cause Mortality in Patients with COPD: Results from the Cohort Study of NHANES 2007&ndash;2010
title_short The Association Between the CALLY Index and All-Cause Mortality in Patients with COPD: Results from the Cohort Study of NHANES 2007&ndash;2010
title_sort association between the cally index and all cause mortality in patients with copd results from the cohort study of nhanes 2007 ndash 2010
topic chronic obstructive pulmonary disease
the c-reactive protein–albumin–lymphocyte index
national health and nutrition examination survey
biomarker.
url https://www.dovepress.com/the-association-between-the-cally-index-and-all-cause-mortality-in-pat-peer-reviewed-fulltext-article-COPD
work_keys_str_mv AT dingy theassociationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT liuy theassociationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT yuj theassociationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT caic theassociationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT ful theassociationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT zhuj theassociationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT yangs theassociationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT jiangy theassociationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT wangj theassociationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT dingy associationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT liuy associationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT yuj associationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT caic associationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT ful associationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT zhuj associationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT yangs associationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT jiangy associationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010
AT wangj associationbetweenthecallyindexandallcausemortalityinpatientswithcopdresultsfromthecohortstudyofnhanes2007ndash2010