Autoimmune encephalitis in psychiatric institutions: current perspectives
Chloe Bost,1–3 Olivier Pascual,2,3 Jérôme Honnorat1–3 1French Reference Center of Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hôpital Neurologique, Bron, France; 2Synatac Team, NeuroMyoGene Institut, INSERM U1...
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Dove Medical Press
2016-10-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| author | Bost C Pascual O Honnorat J |
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| description | Chloe Bost,1–3 Olivier Pascual,2,3 Jérôme Honnorat1–3 1French Reference Center of Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hôpital Neurologique, Bron, France; 2Synatac Team, NeuroMyoGene Institut, INSERM U1217/CNRS UMR5310, Lyon, France; 3University Claude Bernard Lyon 1, Lyon, France Abstract: Autoimmune encephalitis is a rare and newly described group of diseases involving autoantibodies directed against synaptic and neuronal cell surface antigens. It comprises a wide range of neuropsychiatric symptoms. Sensitive and specific diagnostic tests such as cell-based assay are primordial for the detection of neuronal cell surface antibodies in patients’ cerebrospinal fluid or serum and determine the treatment and follow-up of the patients. As neurological symptoms are fairly well described in the literature, this review focuses on the nature of psychiatric symptoms occurring at the onset or during the course of the diseases. In order to help the diagnosis, the main neurological symptoms of the most representative synaptic and neuronal cell surface autoantibodies were detailed. Finally, the exploration of these autoantibodies for almost a decade allowed us to present an overview of autoimmune encephalitis incidence in psychiatric disease and the general guidelines for the management of psychiatric manifestations. For the majority of autoimmune encephalitis, the prognosis depends on the rapidity of the detection, identification, and the management of the disease. Because the presence of pronounced psychiatric symptoms drives patients to psychiatric institutions and can hinder the diagnosis, the aim of this work is to provide clues to help earlier detection by physicians and thus provide better medical care to patients. Keywords: neuroimmunology, autoantibodies, organic psychosis, dementia, schizophrenia |
| format | Article |
| id | doaj-art-3f2eebd9eb5741328d853bde495b3650 |
| institution | Kabale University |
| issn | 1178-2021 |
| language | English |
| publishDate | 2016-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj-art-3f2eebd9eb5741328d853bde495b36502025-08-20T03:27:01ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212016-10-01Volume 12Issue 12775278729717Autoimmune encephalitis in psychiatric institutions: current perspectivesBost CPascual OHonnorat J0French Reference Centre on Paraneoplastic Neurological SyndromeChloe Bost,1–3 Olivier Pascual,2,3 Jérôme Honnorat1–3 1French Reference Center of Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hôpital Neurologique, Bron, France; 2Synatac Team, NeuroMyoGene Institut, INSERM U1217/CNRS UMR5310, Lyon, France; 3University Claude Bernard Lyon 1, Lyon, France Abstract: Autoimmune encephalitis is a rare and newly described group of diseases involving autoantibodies directed against synaptic and neuronal cell surface antigens. It comprises a wide range of neuropsychiatric symptoms. Sensitive and specific diagnostic tests such as cell-based assay are primordial for the detection of neuronal cell surface antibodies in patients’ cerebrospinal fluid or serum and determine the treatment and follow-up of the patients. As neurological symptoms are fairly well described in the literature, this review focuses on the nature of psychiatric symptoms occurring at the onset or during the course of the diseases. In order to help the diagnosis, the main neurological symptoms of the most representative synaptic and neuronal cell surface autoantibodies were detailed. Finally, the exploration of these autoantibodies for almost a decade allowed us to present an overview of autoimmune encephalitis incidence in psychiatric disease and the general guidelines for the management of psychiatric manifestations. For the majority of autoimmune encephalitis, the prognosis depends on the rapidity of the detection, identification, and the management of the disease. Because the presence of pronounced psychiatric symptoms drives patients to psychiatric institutions and can hinder the diagnosis, the aim of this work is to provide clues to help earlier detection by physicians and thus provide better medical care to patients. Keywords: neuroimmunology, autoantibodies, organic psychosis, dementia, schizophreniahttps://www.dovepress.com/autoimmune-encephalitis-in-psychiatric-institutions-current-perspectiv-peer-reviewed-fulltext-article-NDTautoantibodiesencephalitispsychiatryguidelines |
| spellingShingle | Bost C Pascual O Honnorat J Autoimmune encephalitis in psychiatric institutions: current perspectives Neuropsychiatric Disease and Treatment autoantibodies encephalitis psychiatry guidelines |
| title | Autoimmune encephalitis in psychiatric institutions: current perspectives |
| title_full | Autoimmune encephalitis in psychiatric institutions: current perspectives |
| title_fullStr | Autoimmune encephalitis in psychiatric institutions: current perspectives |
| title_full_unstemmed | Autoimmune encephalitis in psychiatric institutions: current perspectives |
| title_short | Autoimmune encephalitis in psychiatric institutions: current perspectives |
| title_sort | autoimmune encephalitis in psychiatric institutions current perspectives |
| topic | autoantibodies encephalitis psychiatry guidelines |
| url | https://www.dovepress.com/autoimmune-encephalitis-in-psychiatric-institutions-current-perspectiv-peer-reviewed-fulltext-article-NDT |
| work_keys_str_mv | AT bostc autoimmuneencephalitisinpsychiatricinstitutionscurrentperspectives AT pascualo autoimmuneencephalitisinpsychiatricinstitutionscurrentperspectives AT honnoratj autoimmuneencephalitisinpsychiatricinstitutionscurrentperspectives |