Research Progress of Liquid Biopsy Based on DNA Methylation in Tumor Diagnosis and Treatment
Liquid biopsy has been gradually applied to the clinical diagnosis and treatment of tumors because of its non-invasive and real-time reflection of the tumor status, as well as the convenience of sample collection, which allows the detection of primary or metastatic malignant tumors and reflects the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/12/1634 |
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| author | Yunxia Bao Xianzhao Wang Bingjie Zeng Yichun Shi Yiman Huang Yiwen Huang Shuang Shang Liang Shan Lifang Ma |
| author_facet | Yunxia Bao Xianzhao Wang Bingjie Zeng Yichun Shi Yiman Huang Yiwen Huang Shuang Shang Liang Shan Lifang Ma |
| author_sort | Yunxia Bao |
| collection | DOAJ |
| description | Liquid biopsy has been gradually applied to the clinical diagnosis and treatment of tumors because of its non-invasive and real-time reflection of the tumor status, as well as the convenience of sample collection, which allows the detection of primary or metastatic malignant tumors and reflects the heterogeneity of the tumors. DNA methylation, which is a type of epigenetic modification, is essential in the progression of tumors. This review introduces the common DNA methylation analysis methods and discusses their advantages and disadvantages, focusing on the new progress of DNA methylation-based liquid biopsy in tumor diagnosis and treatment. |
| format | Article |
| id | doaj-art-3f2df6f3b65548f8a33cf0c2869ed3c3 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-3f2df6f3b65548f8a33cf0c2869ed3c32024-12-27T14:14:00ZengMDPI AGBiomolecules2218-273X2024-12-011412163410.3390/biom14121634Research Progress of Liquid Biopsy Based on DNA Methylation in Tumor Diagnosis and TreatmentYunxia Bao0Xianzhao Wang1Bingjie Zeng2Yichun Shi3Yiman Huang4Yiwen Huang5Shuang Shang6Liang Shan7Lifang Ma8Department of Clinical Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, ChinaLiquid biopsy has been gradually applied to the clinical diagnosis and treatment of tumors because of its non-invasive and real-time reflection of the tumor status, as well as the convenience of sample collection, which allows the detection of primary or metastatic malignant tumors and reflects the heterogeneity of the tumors. DNA methylation, which is a type of epigenetic modification, is essential in the progression of tumors. This review introduces the common DNA methylation analysis methods and discusses their advantages and disadvantages, focusing on the new progress of DNA methylation-based liquid biopsy in tumor diagnosis and treatment.https://www.mdpi.com/2218-273X/14/12/1634DNA methylationtumorepigeneticliquid biopsy |
| spellingShingle | Yunxia Bao Xianzhao Wang Bingjie Zeng Yichun Shi Yiman Huang Yiwen Huang Shuang Shang Liang Shan Lifang Ma Research Progress of Liquid Biopsy Based on DNA Methylation in Tumor Diagnosis and Treatment Biomolecules DNA methylation tumor epigenetic liquid biopsy |
| title | Research Progress of Liquid Biopsy Based on DNA Methylation in Tumor Diagnosis and Treatment |
| title_full | Research Progress of Liquid Biopsy Based on DNA Methylation in Tumor Diagnosis and Treatment |
| title_fullStr | Research Progress of Liquid Biopsy Based on DNA Methylation in Tumor Diagnosis and Treatment |
| title_full_unstemmed | Research Progress of Liquid Biopsy Based on DNA Methylation in Tumor Diagnosis and Treatment |
| title_short | Research Progress of Liquid Biopsy Based on DNA Methylation in Tumor Diagnosis and Treatment |
| title_sort | research progress of liquid biopsy based on dna methylation in tumor diagnosis and treatment |
| topic | DNA methylation tumor epigenetic liquid biopsy |
| url | https://www.mdpi.com/2218-273X/14/12/1634 |
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