Androgen receptor expression in triple negative breast cancer: an Algerian population study
Triple-negative breast cancer (TNBC) is a molecular subtype of breast cancer characterized by the absence of estrogen and progesterone receptors and the lack of HER2 overexpression. TNBC is highly heterogeneous, complicating the identification of new therapeutic targets. However, the expression of t...
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Taylor & Francis Group
2025-12-01
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| Series: | Libyan Journal of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19932820.2025.2535778 |
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| author | Amel Hedjem Amal Kouchkar Amel Ladjeroud Nacera Zerrouki Fatima Benaissa Nasir A. Ibrahim Mohammed Saad Aleissa Nosiba S. Basher Assia Derguini Takfarinas Idres Karim Houali |
| author_facet | Amel Hedjem Amal Kouchkar Amel Ladjeroud Nacera Zerrouki Fatima Benaissa Nasir A. Ibrahim Mohammed Saad Aleissa Nosiba S. Basher Assia Derguini Takfarinas Idres Karim Houali |
| author_sort | Amel Hedjem |
| collection | DOAJ |
| description | Triple-negative breast cancer (TNBC) is a molecular subtype of breast cancer characterized by the absence of estrogen and progesterone receptors and the lack of HER2 overexpression. TNBC is highly heterogeneous, complicating the identification of new therapeutic targets. However, the expression of the androgen receptor (AR) in the luminal androgen receptor (LAR TNBC) subgroup has opened the door to alternative therapeutic approaches. This study aimed to assess AR expression and correlate it with clinicopathological factors in 160 early-stage TNBC patients treated from February 2015 to February 2017. Our findings reveal that AR expression is observed in 16.87% (27/160) of ≥1% AR positivity cases. Moreover, a significant 12.5% (20/160) was found in ≥10% AR positive cases. Positive AR expression was inversely correlated with a high Ki-67 proliferation index and with the basal immunophenotype. The five-year survival rate for our cohort was 83.12%, and no significant association between AR expression and overall survival was observed (p = 0.77). The study highlights the potential role of AR expression in TNBC and its implications for therapeutic strategies, although no significant association with overall survival was found. |
| format | Article |
| id | doaj-art-3f2d92ae9d3d4aa8a2ba22eeb64447af |
| institution | DOAJ |
| issn | 1993-2820 1819-6357 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Libyan Journal of Medicine |
| spelling | doaj-art-3f2d92ae9d3d4aa8a2ba22eeb64447af2025-08-20T02:41:14ZengTaylor & Francis GroupLibyan Journal of Medicine1993-28201819-63572025-12-0120110.1080/19932820.2025.2535778Androgen receptor expression in triple negative breast cancer: an Algerian population studyAmel Hedjem0Amal Kouchkar1Amel Ladjeroud2Nacera Zerrouki3Fatima Benaissa4Nasir A. Ibrahim5Mohammed Saad Aleissa6Nosiba S. Basher7Assia Derguini8Takfarinas Idres9Karim Houali10Department of Biology, Faculty of Sciences, University M’hamed Bougara, Boumerdes, AlgeriaDepartment of Pathology, Pierre and Marie Curie Cancer Center, Algiers, AlgeriaDepartment of Medical, Pierre and Marie Curie Cancer Center, Algiers, AlgeriaLaboratoire Ressources Naturelles, University Mouloud Maameri, Tizi Ouzou, AlgeriaLaboratory of Biomathematics, Biophysics, Biochemistry and Scientometry L3BS, University of Bejaia, Bejaïa, AlgeriaBiology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi ArabiaBiology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi ArabiaBiology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi ArabiaMicrobial Ecology Laboratory, FSNV, Abderrahmane MIRA University, Bejaïa, AlgeriaLaboratory for Livestock Animal Production and Health Research, Rabie Bouchama National Veterinary School of Algiers, Algiers, AlgeriaLaboratory of Analytic Biochemistry and Biotechnology (LABAB), Department of Biochemistry and Microbiology, Faculty of Biological and Agronomic Sciences, Mouloud Mammeri University, Tizi-Ouzou, AlgeriaTriple-negative breast cancer (TNBC) is a molecular subtype of breast cancer characterized by the absence of estrogen and progesterone receptors and the lack of HER2 overexpression. TNBC is highly heterogeneous, complicating the identification of new therapeutic targets. However, the expression of the androgen receptor (AR) in the luminal androgen receptor (LAR TNBC) subgroup has opened the door to alternative therapeutic approaches. This study aimed to assess AR expression and correlate it with clinicopathological factors in 160 early-stage TNBC patients treated from February 2015 to February 2017. Our findings reveal that AR expression is observed in 16.87% (27/160) of ≥1% AR positivity cases. Moreover, a significant 12.5% (20/160) was found in ≥10% AR positive cases. Positive AR expression was inversely correlated with a high Ki-67 proliferation index and with the basal immunophenotype. The five-year survival rate for our cohort was 83.12%, and no significant association between AR expression and overall survival was observed (p = 0.77). The study highlights the potential role of AR expression in TNBC and its implications for therapeutic strategies, although no significant association with overall survival was found.https://www.tandfonline.com/doi/10.1080/19932820.2025.2535778Triple-negative breast cancerandrogen receptorchemotherapyestrogen receptorHER2TNBC classification |
| spellingShingle | Amel Hedjem Amal Kouchkar Amel Ladjeroud Nacera Zerrouki Fatima Benaissa Nasir A. Ibrahim Mohammed Saad Aleissa Nosiba S. Basher Assia Derguini Takfarinas Idres Karim Houali Androgen receptor expression in triple negative breast cancer: an Algerian population study Libyan Journal of Medicine Triple-negative breast cancer androgen receptor chemotherapy estrogen receptor HER2 TNBC classification |
| title | Androgen receptor expression in triple negative breast cancer: an Algerian population study |
| title_full | Androgen receptor expression in triple negative breast cancer: an Algerian population study |
| title_fullStr | Androgen receptor expression in triple negative breast cancer: an Algerian population study |
| title_full_unstemmed | Androgen receptor expression in triple negative breast cancer: an Algerian population study |
| title_short | Androgen receptor expression in triple negative breast cancer: an Algerian population study |
| title_sort | androgen receptor expression in triple negative breast cancer an algerian population study |
| topic | Triple-negative breast cancer androgen receptor chemotherapy estrogen receptor HER2 TNBC classification |
| url | https://www.tandfonline.com/doi/10.1080/19932820.2025.2535778 |
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