Enhancing human ACE2 expression in mouse models to improve COVID‐19 research

Enhancing human ACE2 expression in mouse models to improve COVID‐19 research

Mice are one of the most common biological models for laboratory use. However, wild‐type mice are not susceptible to COVID‐19 infection due to the low affinity of mouse ACE2, the entry protein for SARS‐CoV‐2. Although mice with human ACE2 (hACE2) driven by Ace2 promoter reflect its tissue specificit...

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Bibliographic Details
Main Authors: Sun Jiaoyang, Cheng Shaofei, Hong Guangliang, Quan Xiongzhi, Lin Haofeng, Mao Rui, Johannes Grillari, Shi Zheng‐Li, Chen Jiekai, Liu Meiqin, Wu Haoyu, Wu Guangming
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:FEBS Open Bio
Subjects:
COVID‐19
hACE2
mouse model
β‐globin
Online Access:https://doi.org/10.1002/2211-5463.13934
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