Patient-centred Preferences for Biologic Therapies in Moderate to Severe Psoriasis in Vietnam: A Discrete Choice Experiment
Psoriasis is a chronic autoimmune disease that significantly impairs patients’ quality of life. With the growing availability of biologic drugs – each varying in efficacy, safety, dosing, and cost – treatment decisions have become increasingly complex. A study conducted from March to July 2024 surve...
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| Language: | English |
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Medical Journals Sweden
2025-05-01
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| Series: | Acta Dermato-Venereologica |
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| Online Access: | https://medicaljournalssweden.se/actadv/article/view/42840 |
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| author | Chuyen Thi Hong Nguyen Xuan Thi Mai Nguyen Trung The Van |
| author_facet | Chuyen Thi Hong Nguyen Xuan Thi Mai Nguyen Trung The Van |
| author_sort | Chuyen Thi Hong Nguyen |
| collection | DOAJ |
| description | Psoriasis is a chronic autoimmune disease that significantly impairs patients’ quality of life. With the growing availability of biologic drugs – each varying in efficacy, safety, dosing, and cost – treatment decisions have become increasingly complex. A study conducted from March to July 2024 surveyed 302 Vietnamese patients with moderate to severe psoriasis to assess preferences for biologic therapies. Using a discrete choice experiment (DCE), participants evaluated 6 treatment attributes: short-term efficacy, long-term efficacy, sustained efficacy after drug withdrawal, frequency of administration, copayment, and risk of serious infection. Preference data were analysed using conditional logit models. Analysis revealed that treatment cost (relative importance [RI]: 31.4%) and long-term efficacy (RI: 25.3%) were the most critical factors influencing patient decisions, while sustained efficacy after withdrawal and early onset of efficacy were less impactful. Long-term efficacy and cost consistently ranked highest across all patient subgroups, with variations depending on demographic and clinical characteristics. These findings provide practical guidance for clinicians to incorporate patient preferences into the selection of biologic therapies, with particular emphasis on treatment cost and long-term efficacy. The significant influence of treatment cost also highlights the need for healthcare policymakers in Vietnam to enhance reimbursement policies and financial support programmes, improving access and equity in psoriasis care.
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| format | Article |
| id | doaj-art-3f2c4900934b4101bddd0995ad267b44 |
| institution | OA Journals |
| issn | 0001-5555 1651-2057 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj-art-3f2c4900934b4101bddd0995ad267b442025-08-20T02:14:15ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572025-05-0110510.2340/actadv.v105.42840Patient-centred Preferences for Biologic Therapies in Moderate to Severe Psoriasis in Vietnam: A Discrete Choice ExperimentChuyen Thi Hong Nguyen0Xuan Thi Mai Nguyen1Trung The Van2Department of Dermatology, University of Medicine and Pharmacy at Ho Chi Minh City, VietnamDepartment of Dermatology, University of Medicine and Pharmacy at Ho Chi Minh City, VietnamDepartment of Dermatology, University of Medicine and Pharmacy at Ho Chi Minh City, VietnamPsoriasis is a chronic autoimmune disease that significantly impairs patients’ quality of life. With the growing availability of biologic drugs – each varying in efficacy, safety, dosing, and cost – treatment decisions have become increasingly complex. A study conducted from March to July 2024 surveyed 302 Vietnamese patients with moderate to severe psoriasis to assess preferences for biologic therapies. Using a discrete choice experiment (DCE), participants evaluated 6 treatment attributes: short-term efficacy, long-term efficacy, sustained efficacy after drug withdrawal, frequency of administration, copayment, and risk of serious infection. Preference data were analysed using conditional logit models. Analysis revealed that treatment cost (relative importance [RI]: 31.4%) and long-term efficacy (RI: 25.3%) were the most critical factors influencing patient decisions, while sustained efficacy after withdrawal and early onset of efficacy were less impactful. Long-term efficacy and cost consistently ranked highest across all patient subgroups, with variations depending on demographic and clinical characteristics. These findings provide practical guidance for clinicians to incorporate patient preferences into the selection of biologic therapies, with particular emphasis on treatment cost and long-term efficacy. The significant influence of treatment cost also highlights the need for healthcare policymakers in Vietnam to enhance reimbursement policies and financial support programmes, improving access and equity in psoriasis care. https://medicaljournalssweden.se/actadv/article/view/42840PsoriasisBiologicspatient preferencesdecision making |
| spellingShingle | Chuyen Thi Hong Nguyen Xuan Thi Mai Nguyen Trung The Van Patient-centred Preferences for Biologic Therapies in Moderate to Severe Psoriasis in Vietnam: A Discrete Choice Experiment Acta Dermato-Venereologica Psoriasis Biologics patient preferences decision making |
| title | Patient-centred Preferences for Biologic Therapies in Moderate to Severe Psoriasis in Vietnam: A Discrete Choice Experiment |
| title_full | Patient-centred Preferences for Biologic Therapies in Moderate to Severe Psoriasis in Vietnam: A Discrete Choice Experiment |
| title_fullStr | Patient-centred Preferences for Biologic Therapies in Moderate to Severe Psoriasis in Vietnam: A Discrete Choice Experiment |
| title_full_unstemmed | Patient-centred Preferences for Biologic Therapies in Moderate to Severe Psoriasis in Vietnam: A Discrete Choice Experiment |
| title_short | Patient-centred Preferences for Biologic Therapies in Moderate to Severe Psoriasis in Vietnam: A Discrete Choice Experiment |
| title_sort | patient centred preferences for biologic therapies in moderate to severe psoriasis in vietnam a discrete choice experiment |
| topic | Psoriasis Biologics patient preferences decision making |
| url | https://medicaljournalssweden.se/actadv/article/view/42840 |
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