Vaginal Dysplasia and HIV: An African American and Caribbean American Cohort Study
Background. Vaginal cancer is a rare disease with poor clinical outcomes and limited therapeutic options. In the United States (US), minority women and older women are disproportionately diagnosed with late-stage vaginal cancer. Sociodemographic characteristics, risk behaviors, and cooccurring condi...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2019/6189837 |
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| author | Lunthita M. Duthely Jose A. Carugno Cayla Y. Suthumphong Erica B. Feldman JoNell E. Potter |
| author_facet | Lunthita M. Duthely Jose A. Carugno Cayla Y. Suthumphong Erica B. Feldman JoNell E. Potter |
| author_sort | Lunthita M. Duthely |
| collection | DOAJ |
| description | Background. Vaginal cancer is a rare disease with poor clinical outcomes and limited therapeutic options. In the United States (US), minority women and older women are disproportionately diagnosed with late-stage vaginal cancer. Sociodemographic characteristics, risk behaviors, and cooccurring conditions are linked to vaginal intraepithelial neoplasia (VaIN). The diagnosis of VaIN is more prevalent among older women and women living with HIV (WLWH). The Caribbean basin has one of the highest rates of anogenital cancers in the Western Hemisphere. In the US, vaginal infections are more prevalent among Caribbean women, and these infections contribute to higher rates of Human Papilloma Virus (HPV). Given the high rate of anogenital cancers in the Caribbean and the high rates of HPV among Caribbean women in the US, we sought to describe the occurrence of VaIN in a cohort of Black non-Hispanic WLWH. The cohort was followed by an interdisciplinary team of providers with the University of Miami, Miller School of Medicine. Results. Caribbean Americans were living with HIV longer and more were uninsured; more African Americans endorsed cigarette and illicit substance use. Caribbean Americans trended towards the highest grades of VaIN (VaIN 2+) at baseline, but more African Americans progressed to VaIN 2+ in subsequent biopsies. Conclusion. In this cohort of Caribbean American and African American women living with HIV diagnosed with VaIN, Caribbean Americans had the highest grade of VaIN at baseline, but more African Americans progressed to more advanced stages of the disease. |
| format | Article |
| id | doaj-art-3f2bace2fd90413fa157598080bb5d47 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-3f2bace2fd90413fa157598080bb5d472025-02-03T05:53:55ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982019-01-01201910.1155/2019/61898376189837Vaginal Dysplasia and HIV: An African American and Caribbean American Cohort StudyLunthita M. Duthely0Jose A. Carugno1Cayla Y. Suthumphong2Erica B. Feldman3JoNell E. Potter4Department of Obstetrics and Gynecology, Division of Research and Special Projects Miami, University of Miami Miller School of Medicine, Miami 33101, USADepartment of Obstetrics and Gynecology, University of Miami Miller School of Medicine, Miami 33101, USADepartment of Medical Education, University of Miami Miller School of Medicine, Miami 33101, USADepartment of Medical Education, University of Miami Miller School of Medicine, Miami 33101, USADepartment of Obstetrics and Gynecology, Division of Research and Special Projects Miami, University of Miami Miller School of Medicine, Miami 33101, USABackground. Vaginal cancer is a rare disease with poor clinical outcomes and limited therapeutic options. In the United States (US), minority women and older women are disproportionately diagnosed with late-stage vaginal cancer. Sociodemographic characteristics, risk behaviors, and cooccurring conditions are linked to vaginal intraepithelial neoplasia (VaIN). The diagnosis of VaIN is more prevalent among older women and women living with HIV (WLWH). The Caribbean basin has one of the highest rates of anogenital cancers in the Western Hemisphere. In the US, vaginal infections are more prevalent among Caribbean women, and these infections contribute to higher rates of Human Papilloma Virus (HPV). Given the high rate of anogenital cancers in the Caribbean and the high rates of HPV among Caribbean women in the US, we sought to describe the occurrence of VaIN in a cohort of Black non-Hispanic WLWH. The cohort was followed by an interdisciplinary team of providers with the University of Miami, Miller School of Medicine. Results. Caribbean Americans were living with HIV longer and more were uninsured; more African Americans endorsed cigarette and illicit substance use. Caribbean Americans trended towards the highest grades of VaIN (VaIN 2+) at baseline, but more African Americans progressed to VaIN 2+ in subsequent biopsies. Conclusion. In this cohort of Caribbean American and African American women living with HIV diagnosed with VaIN, Caribbean Americans had the highest grade of VaIN at baseline, but more African Americans progressed to more advanced stages of the disease.http://dx.doi.org/10.1155/2019/6189837 |
| spellingShingle | Lunthita M. Duthely Jose A. Carugno Cayla Y. Suthumphong Erica B. Feldman JoNell E. Potter Vaginal Dysplasia and HIV: An African American and Caribbean American Cohort Study Interdisciplinary Perspectives on Infectious Diseases |
| title | Vaginal Dysplasia and HIV: An African American and Caribbean American Cohort Study |
| title_full | Vaginal Dysplasia and HIV: An African American and Caribbean American Cohort Study |
| title_fullStr | Vaginal Dysplasia and HIV: An African American and Caribbean American Cohort Study |
| title_full_unstemmed | Vaginal Dysplasia and HIV: An African American and Caribbean American Cohort Study |
| title_short | Vaginal Dysplasia and HIV: An African American and Caribbean American Cohort Study |
| title_sort | vaginal dysplasia and hiv an african american and caribbean american cohort study |
| url | http://dx.doi.org/10.1155/2019/6189837 |
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