Research progress of SOCS in autoimmune diseases: mechanisms and therapeutic implications
Suppressor of cytokine signaling (SOCS) is a family of regulatory factors whose expression can be induced by various cytokines, growth factors, and hormones. Autoimmune diseases, chronic inflammatory conditions caused by abnormal immune responses, involve overactive T-cells and B-cells, excessive au...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1604271/full |
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| author | Rongqi Cui Jing Zhang |
| author_facet | Rongqi Cui Jing Zhang |
| author_sort | Rongqi Cui |
| collection | DOAJ |
| description | Suppressor of cytokine signaling (SOCS) is a family of regulatory factors whose expression can be induced by various cytokines, growth factors, and hormones. Autoimmune diseases, chronic inflammatory conditions caused by abnormal immune responses, involve overactive T-cells and B-cells, excessive autoantibody production, and damage to multiple organs and systems. The pathogenic mechanisms of autoimmune diseases are complex, and SOCS proteins, particularly SOCS1, SOCS2, SOCS3, and SOCS5, regulate cytokine receptor signaling through distinct mechanisms, thereby participating in the development and progression of autoimmune diseases. This positions SOCS proteins as potential therapeutic targets for modulating dysregulated immune responses in autoimmune diseases. |
| format | Article |
| id | doaj-art-3f2aa48802fa4048bed3739fc5124995 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-3f2aa48802fa4048bed3739fc51249952025-08-20T03:28:01ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-07-011610.3389/fimmu.2025.16042711604271Research progress of SOCS in autoimmune diseases: mechanisms and therapeutic implicationsRongqi Cui0Jing Zhang1China Medical University, Shenyang, Liaoning, ChinaDepartment of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaSuppressor of cytokine signaling (SOCS) is a family of regulatory factors whose expression can be induced by various cytokines, growth factors, and hormones. Autoimmune diseases, chronic inflammatory conditions caused by abnormal immune responses, involve overactive T-cells and B-cells, excessive autoantibody production, and damage to multiple organs and systems. The pathogenic mechanisms of autoimmune diseases are complex, and SOCS proteins, particularly SOCS1, SOCS2, SOCS3, and SOCS5, regulate cytokine receptor signaling through distinct mechanisms, thereby participating in the development and progression of autoimmune diseases. This positions SOCS proteins as potential therapeutic targets for modulating dysregulated immune responses in autoimmune diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1604271/fullSOCSautoimmune diseasesimmunityJAK-STATcytokines |
| spellingShingle | Rongqi Cui Jing Zhang Research progress of SOCS in autoimmune diseases: mechanisms and therapeutic implications Frontiers in Immunology SOCS autoimmune diseases immunity JAK-STAT cytokines |
| title | Research progress of SOCS in autoimmune diseases: mechanisms and therapeutic implications |
| title_full | Research progress of SOCS in autoimmune diseases: mechanisms and therapeutic implications |
| title_fullStr | Research progress of SOCS in autoimmune diseases: mechanisms and therapeutic implications |
| title_full_unstemmed | Research progress of SOCS in autoimmune diseases: mechanisms and therapeutic implications |
| title_short | Research progress of SOCS in autoimmune diseases: mechanisms and therapeutic implications |
| title_sort | research progress of socs in autoimmune diseases mechanisms and therapeutic implications |
| topic | SOCS autoimmune diseases immunity JAK-STAT cytokines |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1604271/full |
| work_keys_str_mv | AT rongqicui researchprogressofsocsinautoimmunediseasesmechanismsandtherapeuticimplications AT jingzhang researchprogressofsocsinautoimmunediseasesmechanismsandtherapeuticimplications |