Recent advances of P38MAPK signaling pathway in diabetic nephropathy
As one of the most serious chronic complications of diabetes, diabetic nephropathy is a major cause of chronic renal failure.P38 MAPK is an important signal transduction molecule in MAPK signal pathway.It accelerates the process of diabetic nephropathy by stimulating the production of reactive oxyge...
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| Main Authors: | , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2021-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57903965&Fpath=home&index=0 |
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| Summary: | As one of the most serious chronic complications of diabetes, diabetic nephropathy is a major cause of chronic renal failure.P38 MAPK is an important signal transduction molecule in MAPK signal pathway.It accelerates the process of diabetic nephropathy by stimulating the production of reactive oxygen species, boosting the release of inflammatory mediators, regulating renin-angiotensin system and affecting the formation and degradation of glomerular mesangial matrix.And p38 MAPK inhibitor and traditional Chinese medicine with p38 MAPK as therapeutic target are expected to become new pharmaceutical preparations for diabetic nephropathy. |
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| ISSN: | 1671-2390 |