Relationship Between Location of Cell Transplantation and Recovery for Intracerebral Stem Cell Transplantation for Chronic Traumatic Brain Injury: Post-hoc Analysis of STEMTRA Trial
Traumatic brain injury is a world-leading cause of disability. Current treatments are not sufficient to promote neurological recovery. Intracerebral transplantation of allogeneic mesenchymal stem cells, specifically SB623, has shown promise in achieving better neurological recovery compared with a s...
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| Language: | English |
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Mary Ann Liebert
2025-01-01
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| Series: | Neurotrauma Reports |
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| Online Access: | https://www.liebertpub.com/doi/10.1089/neur.2024.0130 |
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| author | Masahito Kawabori Yasuaki Karasawa Jun Suenaga Hajime Nakamura Hideaki Imai Takao Yasuhara Naoki Tani Tatsuya Sasaki Takashi Kawasaki Kenta Totsuka Dai Chida Yoichi M. Ito Tetsuya Yamamoto Isao Date Shota Tanaka Haruhiko Kishima Miki Fujimura |
| author_facet | Masahito Kawabori Yasuaki Karasawa Jun Suenaga Hajime Nakamura Hideaki Imai Takao Yasuhara Naoki Tani Tatsuya Sasaki Takashi Kawasaki Kenta Totsuka Dai Chida Yoichi M. Ito Tetsuya Yamamoto Isao Date Shota Tanaka Haruhiko Kishima Miki Fujimura |
| author_sort | Masahito Kawabori |
| collection | DOAJ |
| description | Traumatic brain injury is a world-leading cause of disability. Current treatments are not sufficient to promote neurological recovery. Intracerebral transplantation of allogeneic mesenchymal stem cells, specifically SB623, has shown promise in achieving better neurological recovery compared with a sham surgery group in the STEMTRA trial. However, the optimal location for cell transplantation remains unclear, as transplanted lesions vary between patients. This study aimed to explore the relationship between functional recovery and the location of transplanted lesions. This study included all Japanese subjects from the STEMTRA trial who were assigned to the cell transplantation group. Functional recovery was assessed by the difference in Fugl–Meyer Motor Scale (FMMS) scores between the screening period and 24 or 48 weeks post-transplantation. An FMMS score improvement of >8 was defined as an improved group. Lesions responsible for motor deficits were categorized into three groups: motor cortex (Cortex), deep white matter (DWM), or both (Cortex and DWM). Data on the 15 transplanted sites per patient were obtained from surgical navigation software, and the distance from the damaged area to the transplanted sites was calculated. Twelve patients were included in this post-hoc analysis. No patients in the 2.5 × 106 cells group showed improvement and were therefore excluded from further analysis. Five patients were categorized into the Cortex group and four into the DWM group. The distance between the transplanted site and the injury point ranged from 0 to 39 mm. A moderate to strong trend of correlations was observed, suggesting that a shorter distance is preferable for the motor cortex group, while a greater distance is preferable for the DWM group. The optimal site for stem cell transplantation may be different from the damaged site of the patient; however, a further large number cohort is necessary to elucidate this hypothesis. |
| format | Article |
| id | doaj-art-3f280ff985ab413c86f951d97eeea255 |
| institution | OA Journals |
| issn | 2689-288X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Neurotrauma Reports |
| spelling | doaj-art-3f280ff985ab413c86f951d97eeea2552025-08-20T02:30:54ZengMary Ann LiebertNeurotrauma Reports2689-288X2025-01-016110611410.1089/neur.2024.0130Relationship Between Location of Cell Transplantation and Recovery for Intracerebral Stem Cell Transplantation for Chronic Traumatic Brain Injury: Post-hoc Analysis of STEMTRA TrialMasahito Kawabori0Yasuaki Karasawa1Jun Suenaga2Hajime Nakamura3Hideaki Imai4Takao Yasuhara5Naoki Tani6Tatsuya Sasaki7Takashi Kawasaki8Kenta Totsuka9Dai Chida10Yoichi M. Ito11Tetsuya Yamamoto12Isao Date13Shota Tanaka14Haruhiko Kishima15Miki Fujimura16Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.Department of Neurosurgery, Yokohama City University School of Medicine, Yokohama, Japan.Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan.Department of Neurosurgery, JCHO Tokyo Shinjuku Medical Center, Tokyo, Japan.Department of Neurological Surgery, Okayama University Graduate School of Medicine, Okayama University Hospital, Okayama, Japan.Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan.Department of Neurological Surgery, Okayama University Graduate School of Medicine, Okayama University Hospital, Okayama, Japan.Department of Neurosurgery, Yokohama City University School of Medicine, Yokohama, Japan.Micron, Inc., Tokyo, Japan.SanBio, Inc., Tokyo, Japan.Biostatistics Division, Institute of Health Science Innovation for Medical Care, Hokkaido University Hospital, Sapporo, Japan.Department of Neurosurgery, Yokohama City University School of Medicine, Yokohama, Japan.Department of Neurological Surgery, Okayama University Graduate School of Medicine, Okayama University Hospital, Okayama, Japan.Department of Neurological Surgery, Okayama University Graduate School of Medicine, Okayama University Hospital, Okayama, Japan.Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan.Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.Traumatic brain injury is a world-leading cause of disability. Current treatments are not sufficient to promote neurological recovery. Intracerebral transplantation of allogeneic mesenchymal stem cells, specifically SB623, has shown promise in achieving better neurological recovery compared with a sham surgery group in the STEMTRA trial. However, the optimal location for cell transplantation remains unclear, as transplanted lesions vary between patients. This study aimed to explore the relationship between functional recovery and the location of transplanted lesions. This study included all Japanese subjects from the STEMTRA trial who were assigned to the cell transplantation group. Functional recovery was assessed by the difference in Fugl–Meyer Motor Scale (FMMS) scores between the screening period and 24 or 48 weeks post-transplantation. An FMMS score improvement of >8 was defined as an improved group. Lesions responsible for motor deficits were categorized into three groups: motor cortex (Cortex), deep white matter (DWM), or both (Cortex and DWM). Data on the 15 transplanted sites per patient were obtained from surgical navigation software, and the distance from the damaged area to the transplanted sites was calculated. Twelve patients were included in this post-hoc analysis. No patients in the 2.5 × 106 cells group showed improvement and were therefore excluded from further analysis. Five patients were categorized into the Cortex group and four into the DWM group. The distance between the transplanted site and the injury point ranged from 0 to 39 mm. A moderate to strong trend of correlations was observed, suggesting that a shorter distance is preferable for the motor cortex group, while a greater distance is preferable for the DWM group. The optimal site for stem cell transplantation may be different from the damaged site of the patient; however, a further large number cohort is necessary to elucidate this hypothesis.https://www.liebertpub.com/doi/10.1089/neur.2024.0130chronicintracerebral transplantationrecoverystem celltraumatic brain injury |
| spellingShingle | Masahito Kawabori Yasuaki Karasawa Jun Suenaga Hajime Nakamura Hideaki Imai Takao Yasuhara Naoki Tani Tatsuya Sasaki Takashi Kawasaki Kenta Totsuka Dai Chida Yoichi M. Ito Tetsuya Yamamoto Isao Date Shota Tanaka Haruhiko Kishima Miki Fujimura Relationship Between Location of Cell Transplantation and Recovery for Intracerebral Stem Cell Transplantation for Chronic Traumatic Brain Injury: Post-hoc Analysis of STEMTRA Trial Neurotrauma Reports chronic intracerebral transplantation recovery stem cell traumatic brain injury |
| title | Relationship Between Location of Cell Transplantation and Recovery for Intracerebral Stem Cell Transplantation for Chronic Traumatic Brain Injury: Post-hoc Analysis of STEMTRA Trial |
| title_full | Relationship Between Location of Cell Transplantation and Recovery for Intracerebral Stem Cell Transplantation for Chronic Traumatic Brain Injury: Post-hoc Analysis of STEMTRA Trial |
| title_fullStr | Relationship Between Location of Cell Transplantation and Recovery for Intracerebral Stem Cell Transplantation for Chronic Traumatic Brain Injury: Post-hoc Analysis of STEMTRA Trial |
| title_full_unstemmed | Relationship Between Location of Cell Transplantation and Recovery for Intracerebral Stem Cell Transplantation for Chronic Traumatic Brain Injury: Post-hoc Analysis of STEMTRA Trial |
| title_short | Relationship Between Location of Cell Transplantation and Recovery for Intracerebral Stem Cell Transplantation for Chronic Traumatic Brain Injury: Post-hoc Analysis of STEMTRA Trial |
| title_sort | relationship between location of cell transplantation and recovery for intracerebral stem cell transplantation for chronic traumatic brain injury post hoc analysis of stemtra trial |
| topic | chronic intracerebral transplantation recovery stem cell traumatic brain injury |
| url | https://www.liebertpub.com/doi/10.1089/neur.2024.0130 |
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