Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure
In the present study, the CA III and IV autoantibodies, CA activity, antioxidant enzymes and cytokines in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), diabetes, hypertensive renal disease, and heart failure were investigated. The anti-CA III antibody titers in patients with RA, SLE...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/354594 |
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| author | Chengeng Liu Yue Wei Jianmin Wang Langan Pi Jianjun Huang Peichang Wang |
| author_facet | Chengeng Liu Yue Wei Jianmin Wang Langan Pi Jianjun Huang Peichang Wang |
| author_sort | Chengeng Liu |
| collection | DOAJ |
| description | In the present study, the CA III and IV autoantibodies, CA activity, antioxidant enzymes and cytokines in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), diabetes, hypertensive renal disease, and heart failure were investigated. The anti-CA III antibody titers in patients with RA, SLE, and type 1 diabetes (T1D) were significantly higher than that in control groups (P<0.05). The anti-CA IV antibody titers in patients with RA, SLE, type 1 diabetic nephropathy (T1DN), and heart failure were significantly higher than that in control groups (P<0.05) while anti-CA IV antibody could suppress the total CA activity. The SOD and GPx levels in patients with RA, SLE, and T1DN were significantly lower than that in control groups (P<0.05). IL-6, IL-17, IFN-γ, and TNF-α levels were significantly higher in SLE group compared with the control group (P<0.05). Weak but significant correlations were found between anti-CA III antibodies and ESR in RA (r=0.403, P=0.013) and SLE patients (r=0.397, P=0.007). These results suggested that the generation of CA III and IV autoantibodies, antioxidant enzymes, and cytokines might influence each other and CA autoantibodies might affect the normal physiology function of CA. |
| format | Article |
| id | doaj-art-3f2767059f4949c1987eb3efdb509001 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-3f2767059f4949c1987eb3efdb5090012025-02-03T01:10:34ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/354594354594Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart FailureChengeng Liu0Yue Wei1Jianmin Wang2Langan Pi3Jianjun Huang4Peichang Wang5Department of Clinical Laboratory, Xuanwu Hospital, Capital Medical University, 45 Changchun Road, Beijing 100053, ChinaDepartment of Oncology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, ChinaDepartment of Clinical Immune, Xiangya School of Medicine, Central South University, Changsha 410078, Hunan, ChinaDepartment of Clinical Immune, Xiangya School of Medicine, Central South University, Changsha 410078, Hunan, ChinaDepartment of Clinical Immune, Xiangya School of Medicine, Central South University, Changsha 410078, Hunan, ChinaDepartment of Clinical Laboratory, Xuanwu Hospital, Capital Medical University, 45 Changchun Road, Beijing 100053, ChinaIn the present study, the CA III and IV autoantibodies, CA activity, antioxidant enzymes and cytokines in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), diabetes, hypertensive renal disease, and heart failure were investigated. The anti-CA III antibody titers in patients with RA, SLE, and type 1 diabetes (T1D) were significantly higher than that in control groups (P<0.05). The anti-CA IV antibody titers in patients with RA, SLE, type 1 diabetic nephropathy (T1DN), and heart failure were significantly higher than that in control groups (P<0.05) while anti-CA IV antibody could suppress the total CA activity. The SOD and GPx levels in patients with RA, SLE, and T1DN were significantly lower than that in control groups (P<0.05). IL-6, IL-17, IFN-γ, and TNF-α levels were significantly higher in SLE group compared with the control group (P<0.05). Weak but significant correlations were found between anti-CA III antibodies and ESR in RA (r=0.403, P=0.013) and SLE patients (r=0.397, P=0.007). These results suggested that the generation of CA III and IV autoantibodies, antioxidant enzymes, and cytokines might influence each other and CA autoantibodies might affect the normal physiology function of CA.http://dx.doi.org/10.1155/2012/354594 |
| spellingShingle | Chengeng Liu Yue Wei Jianmin Wang Langan Pi Jianjun Huang Peichang Wang Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure Clinical and Developmental Immunology |
| title | Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure |
| title_full | Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure |
| title_fullStr | Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure |
| title_full_unstemmed | Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure |
| title_short | Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure |
| title_sort | carbonic anhydrases iii and iv autoantibodies in rheumatoid arthritis systemic lupus erythematosus diabetes hypertensive renal disease and heart failure |
| url | http://dx.doi.org/10.1155/2012/354594 |
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