Mycobacterium tuberculosis specific CD8(+) T cells rapidly decline with antituberculosis treatment.

Mycobacterium tuberculosis specific CD8(+) T cells rapidly decline with antituberculosis treatment.

<h4>Rationale</h4>Biomarkers associated with response to therapy in tuberculosis could have broad clinical utility. We postulated that the frequency of Mycobacterium tuberculosis (Mtb) specific CD8(+) T cells, by virtue of detecting intracellular infection, could be a surrogate marker of...

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Main Authors: Melissa R Nyendak, Byung Park, Megan D Null, Joy Baseke, Gwendolyn Swarbrick, Harriet Mayanja-Kizza, Mary Nsereko, Denise F Johnson, Phineas Gitta, Alphonse Okwera, Stefan Goldberg, Lorna Bozeman, John L Johnson, W Henry Boom, Deborah A Lewinsohn, David M Lewinsohn, Tuberculosis Research Unit and the Tuberculosis Trials Consortium
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0081564
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