Generating neurons in the embryonic and adult brain: compared principles and mechanisms
Neurogenesis is a lifelong process, generating neurons in the right amount, time and place and with the correct identity to permit the growth, function, plasticity and repair of the nervous system, notably the brain. Neurogenesis originates from neural progenitor cells (NPs), endowed with the capaci...
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Académie des sciences
2024-11-01
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| Series: | Comptes Rendus Biologies |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.167/ |
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| author | Chouly, Mathilde Bally-Cuif, Laure |
| author_facet | Chouly, Mathilde Bally-Cuif, Laure |
| author_sort | Chouly, Mathilde |
| collection | DOAJ |
| description | Neurogenesis is a lifelong process, generating neurons in the right amount, time and place and with the correct identity to permit the growth, function, plasticity and repair of the nervous system, notably the brain. Neurogenesis originates from neural progenitor cells (NPs), endowed with the capacity to divide, renew to maintain the progenitor population, or commit to engage in the neurogenesis process. In the adult brain, these progenitors are classically called neural stem cells (NSCs). We review here the commonalities and differences between NPs and NSCs, in their cellular and molecular attributes but also in their potential, regulators and lineage, in the embryonic and adult brains. Our comparison is based on the two most studied model systems, namely the telencephalon of the zebrafish and mouse. We also discuss how the population of embryonic NPs gives rise to adult NSCs, and outstanding questions pertaining to this transition. |
| format | Article |
| id | doaj-art-3f1da7f57ee3425498c0104f54fd6dec |
| institution | Kabale University |
| issn | 1768-3238 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus Biologies |
| spelling | doaj-art-3f1da7f57ee3425498c0104f54fd6dec2025-02-07T10:37:47ZengAcadémie des sciencesComptes Rendus Biologies1768-32382024-11-01347G119922110.5802/crbiol.16710.5802/crbiol.167Generating neurons in the embryonic and adult brain: compared principles and mechanismsChouly, Mathilde0Bally-Cuif, Laure1https://orcid.org/0000-0001-6611-6274Institut Pasteur, Université Paris Cité, CNRS UMR3738, Zebrafish Neurogenetics Unit, F-75015 Paris, France; Sorbonne Université, Collège doctoral, 75005 Paris, FranceInstitut Pasteur, Université Paris Cité, CNRS UMR3738, Zebrafish Neurogenetics Unit, F-75015 Paris, FranceNeurogenesis is a lifelong process, generating neurons in the right amount, time and place and with the correct identity to permit the growth, function, plasticity and repair of the nervous system, notably the brain. Neurogenesis originates from neural progenitor cells (NPs), endowed with the capacity to divide, renew to maintain the progenitor population, or commit to engage in the neurogenesis process. In the adult brain, these progenitors are classically called neural stem cells (NSCs). We review here the commonalities and differences between NPs and NSCs, in their cellular and molecular attributes but also in their potential, regulators and lineage, in the embryonic and adult brains. Our comparison is based on the two most studied model systems, namely the telencephalon of the zebrafish and mouse. We also discuss how the population of embryonic NPs gives rise to adult NSCs, and outstanding questions pertaining to this transition.https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.167/Neural progenitorNeural stem cellZebrafishMousePalliumNotch signaling |
| spellingShingle | Chouly, Mathilde Bally-Cuif, Laure Generating neurons in the embryonic and adult brain: compared principles and mechanisms Comptes Rendus Biologies Neural progenitor Neural stem cell Zebrafish Mouse Pallium Notch signaling |
| title | Generating neurons in the embryonic and adult brain: compared principles and mechanisms |
| title_full | Generating neurons in the embryonic and adult brain: compared principles and mechanisms |
| title_fullStr | Generating neurons in the embryonic and adult brain: compared principles and mechanisms |
| title_full_unstemmed | Generating neurons in the embryonic and adult brain: compared principles and mechanisms |
| title_short | Generating neurons in the embryonic and adult brain: compared principles and mechanisms |
| title_sort | generating neurons in the embryonic and adult brain compared principles and mechanisms |
| topic | Neural progenitor Neural stem cell Zebrafish Mouse Pallium Notch signaling |
| url | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.167/ |
| work_keys_str_mv | AT choulymathilde generatingneuronsintheembryonicandadultbraincomparedprinciplesandmechanisms AT ballycuiflaure generatingneuronsintheembryonicandadultbraincomparedprinciplesandmechanisms |