Mechanism and Therapeutic Progress of One-Carbon Metabolic Key Enzyme: Serine Hydroxymethyltransferase 2 in Cancer

Mechanism and Therapeutic Progress of One-Carbon Metabolic Key Enzyme: Serine Hydroxymethyltransferase 2 in Cancer

Serine hydroxymethyltransferase 2 (SHMT2) is a crucial mitochondrial enzyme in 1-carbon (1C) metabolism. It catalyzes the conversion of serine to glycine, generating 1C units essential for purine and pyrimidine synthesis, thereby supporting DNA replication and repair. Abnormally high expression is a...

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Bibliographic Details
Main Authors:	Siqiang Zhu, Yuan Liu, Hao Chen, Xingyu Zhu, Xinyu Liu, Kang Xu, Yaodong Sang, Liang Shang, Wei Chong, Leping Li
Format:	Article
Language:	English
Published:	SAGE Publishing 2025-05-01
Series:	Clinical Medicine Insights: Oncology
Online Access:	https://doi.org/10.1177/11795549251331755
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