Interrelation of indicators of oxygen metabolism of neutrophils and antiendotoxin immune as a marker of the postoperative period in patients with acute colonic obstruction
One of the most severe common diseases in abdominal surgery requiring emergency surgical intervention is acute colonic obstruction. The focus of purulent inflammation in the abdominal cavity serves as a source of concentration of antimicrobial mechanisms, among which the central role is played by ne...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Open Systems Publication
2023-07-01
|
| Series: | Лечащий Врач |
| Subjects: | |
| Online Access: | https://journal.lvrach.ru/jour/article/view/1076 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | One of the most severe common diseases in abdominal surgery requiring emergency surgical intervention is acute colonic obstruction. The focus of purulent inflammation in the abdominal cavity serves as a source of concentration of antimicrobial mechanisms, among which the central role is played by neutrophilic granulocytes and factors cooperating with them. The target was to study the indicators of oxygen metabolism of neutrophilic granulocytes at the stage of the postoperative period in patients with ABO and a marker of increasing endotoxinemia. The article reflects effective approaches to monitoring the course of the postoperative period in 157 patients operated on for acute colonic obstruction. The main group (first) consisted of 97 (61.78%) patients, in the abdominal cavity of which a purulent-inflammatory process was detected. The comparison group (second) included 60 (38.22%) patients with a smooth course of the disease. The control group consisted of 23 conditionally healthy people. Special research methods included the assessment of the state of the microbicidal function of neutrophilic granulocytes using reactive spontaneous (SSLCL) and zymosan-induced luminol-dependent chemiluminescence tests (ILZHL). Specific indicators of humoral AB immunity were recorded by determining the concentration of antibodies to lipopolysaccharide (LPS) antigens of E. coli O14, glycolipid (HLP) of Pseudomonas aeruginosa Re-mutant, Proteus mirabilis. An analysis of the SLCL parameters in all patients upon admission revealed their significant increase, and in the main group it persisted for 7-8 days. A different dynamics of neutrophilic granulocytes biocidal activity was noted in these patients during the study of AB protection. Through a dynamic study of the indicators of oxygen metabolism and specific antiendotoxin immunity of gram-negative intestinal microflora, their direct dependence on the clinical course and the development of pyoinflammatory complications was established. It was noted that 2-3 days after the surgical intervention in patients of the main group, there was a significant decrease in the indicators of HLP, LPS E. coli O14 and Proteus mirabilis, which closely correlated with the lack of reserves of antimicrobial biocidal activity of neutrophilic granulocytes. Delayed stabilization of indicators preceded an unfavorable outcome of the course of the disease. The relationship between the parameters of oxygen metabolism of neutrophilic granulocytes and specific antiendotoxin immunity was established, which reflects the nature of the course of the postoperative period in patients with AIO. Testing of indicators of the biocidal reserve of neutrophilic granulocytes according to the reaction of ILZHL can be used as a screening indication of the prognosis of the course of the postoperative period and the formation of pyoinflammatory complications. |
|---|---|
| ISSN: | 1560-5175 2687-1181 |