A bioinformatics analysis of the correlation between hepatic ischemia–reperfusion injury and postoperative cognitive dysfunction
BackgroundPostoperative cognitive dysfunction (POCD) is a common postoperative complication that is prevalent in elderly people. An increasing number of elderly patients are undergoing surgery. As a result, the number of patients presenting with POCD is increasing. Previous studies have demonstrated...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2025.1607446/full |
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| author | Qing Hu Haijie Liu Yunfei Bao Zhihao Feng Hongbo Zhang Jianling Li |
| author_facet | Qing Hu Haijie Liu Yunfei Bao Zhihao Feng Hongbo Zhang Jianling Li |
| author_sort | Qing Hu |
| collection | DOAJ |
| description | BackgroundPostoperative cognitive dysfunction (POCD) is a common postoperative complication that is prevalent in elderly people. An increasing number of elderly patients are undergoing surgery. As a result, the number of patients presenting with POCD is increasing. Previous studies have demonstrated that hepatic ischemia–reperfusion injury (HIRI) in mice is associated with postoperative cognitive impairment. Therefore, this study investigated the relationship between POCD and HIRI using bioinformatics research methods.MethodsThe Gene Expression Omnibus (GEO) database GSE202565 and GeneCards data were selected for correlation analysis using bioinformatics analysis methods. The GSE112713 dataset from the GEO database was chosen for preliminary validation of the screened hub genes.ResultsWe analyzed the dataset GSE202565 for differences in gene expression before and after hepatic post-ischemic reperfusion and obtained a total of 53 genes by identifying POCD-related genes. We also screened these 53 genes again and obtained 10 hub genes, which were analyzed and used for correlation prediction. Finally, these 10 hub genes were partially and preliminarily validated using the dataset GSE112713.ConclusionHIRI is closely related to POCD, and reducing the occurrence of HIRI may become one of the ways to avoid or improve postoperative cognitive impairment in the future. |
| format | Article |
| id | doaj-art-3f1790d1dc3e45f9bd6b5fbf809c06d0 |
| institution | DOAJ |
| issn | 1664-8021 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj-art-3f1790d1dc3e45f9bd6b5fbf809c06d02025-08-20T03:15:20ZengFrontiers Media S.A.Frontiers in Genetics1664-80212025-07-011610.3389/fgene.2025.16074461607446A bioinformatics analysis of the correlation between hepatic ischemia–reperfusion injury and postoperative cognitive dysfunctionQing Hu0Haijie Liu1Yunfei Bao2Zhihao Feng3Hongbo Zhang4Jianling Li5The Affiliated Hospital of Chengde Medical University, Hebei Province Key Laboratory of Pan-Vascular Diseases Chengde, Hebei, ChinaThe Affiliated Hospital of Chengde Medical University, Hebei Province Key Laboratory of Pan-Vascular Diseases Chengde, Hebei, ChinaThe Affiliated Hospital of Chengde Medical University, Hebei Province Key Laboratory of Pan-Vascular Diseases Chengde, Hebei, ChinaThe Affiliated Hospital of Chengde Medical University, Hebei Province Key Laboratory of Pan-Vascular Diseases Chengde, Hebei, ChinaChengde Medical University, Chengde, ChinaThe Affiliated Hospital of Chengde Medical University, Hebei Province Key Laboratory of Pan-Vascular Diseases Chengde, Hebei, ChinaBackgroundPostoperative cognitive dysfunction (POCD) is a common postoperative complication that is prevalent in elderly people. An increasing number of elderly patients are undergoing surgery. As a result, the number of patients presenting with POCD is increasing. Previous studies have demonstrated that hepatic ischemia–reperfusion injury (HIRI) in mice is associated with postoperative cognitive impairment. Therefore, this study investigated the relationship between POCD and HIRI using bioinformatics research methods.MethodsThe Gene Expression Omnibus (GEO) database GSE202565 and GeneCards data were selected for correlation analysis using bioinformatics analysis methods. The GSE112713 dataset from the GEO database was chosen for preliminary validation of the screened hub genes.ResultsWe analyzed the dataset GSE202565 for differences in gene expression before and after hepatic post-ischemic reperfusion and obtained a total of 53 genes by identifying POCD-related genes. We also screened these 53 genes again and obtained 10 hub genes, which were analyzed and used for correlation prediction. Finally, these 10 hub genes were partially and preliminarily validated using the dataset GSE112713.ConclusionHIRI is closely related to POCD, and reducing the occurrence of HIRI may become one of the ways to avoid or improve postoperative cognitive impairment in the future.https://www.frontiersin.org/articles/10.3389/fgene.2025.1607446/fullliver ischemia–reperfusion injurypostoperative cognitive dysfunctionbioinformatics analysisdrug–gene interaction predictionmiRNA prediction |
| spellingShingle | Qing Hu Haijie Liu Yunfei Bao Zhihao Feng Hongbo Zhang Jianling Li A bioinformatics analysis of the correlation between hepatic ischemia–reperfusion injury and postoperative cognitive dysfunction Frontiers in Genetics liver ischemia–reperfusion injury postoperative cognitive dysfunction bioinformatics analysis drug–gene interaction prediction miRNA prediction |
| title | A bioinformatics analysis of the correlation between hepatic ischemia–reperfusion injury and postoperative cognitive dysfunction |
| title_full | A bioinformatics analysis of the correlation between hepatic ischemia–reperfusion injury and postoperative cognitive dysfunction |
| title_fullStr | A bioinformatics analysis of the correlation between hepatic ischemia–reperfusion injury and postoperative cognitive dysfunction |
| title_full_unstemmed | A bioinformatics analysis of the correlation between hepatic ischemia–reperfusion injury and postoperative cognitive dysfunction |
| title_short | A bioinformatics analysis of the correlation between hepatic ischemia–reperfusion injury and postoperative cognitive dysfunction |
| title_sort | bioinformatics analysis of the correlation between hepatic ischemia reperfusion injury and postoperative cognitive dysfunction |
| topic | liver ischemia–reperfusion injury postoperative cognitive dysfunction bioinformatics analysis drug–gene interaction prediction miRNA prediction |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2025.1607446/full |
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