Advances in the relationship between AP-1 and tumorigenesis, development and therapy resistance
Abstract Activating protein 1 (AP-1) is a transcription factor composed of several protein families, Jun proteins and Fos proteins are the components of AP-1. AP-1 is involved in various cellular processes, such as proliferation, differentiation, apoptosis and inflammation. For tumor cells, AP-1 is...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01783-1 |
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| _version_ | 1832585628154331136 |
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| author | Xinni Xue Zhiwei Li Jiahui Zhao Ziyi Zhao Zhihang Li Yong Li Yawen Liu Huan He |
| author_facet | Xinni Xue Zhiwei Li Jiahui Zhao Ziyi Zhao Zhihang Li Yong Li Yawen Liu Huan He |
| author_sort | Xinni Xue |
| collection | DOAJ |
| description | Abstract Activating protein 1 (AP-1) is a transcription factor composed of several protein families, Jun proteins and Fos proteins are the components of AP-1. AP-1 is involved in various cellular processes, such as proliferation, differentiation, apoptosis and inflammation. For tumor cells, AP-1 is considered to be a driver whose activity is associated with dysfunction and the onset, development, invasion, and migration of cancer. In addition, AP-1 has been reported to be involved in the drug resistance and radiation resistance of tumor cells during the treatment process. Therefore, AP-1 is a potential target for cancer therapy. At present, a number of inhibitors targeting AP-1 have been developed and have shown certain anti-cancer effects. However, due to the complex structure and function of AP-1, different structures of AP-1 show different effects in different tumor cells, and more studies are needed to reveal its mechanism of action. This article introduces the relationship between AP-1 and tumor development, summarize the current studies and developments of AP-1 related drugs, and provide the future development values of AP-1. |
| format | Article |
| id | doaj-art-3f0de95b44c34926acfd98b2979e317b |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-3f0de95b44c34926acfd98b2979e317b2025-01-26T12:40:00ZengSpringerDiscover Oncology2730-60112025-01-0116111510.1007/s12672-025-01783-1Advances in the relationship between AP-1 and tumorigenesis, development and therapy resistanceXinni Xue0Zhiwei Li1Jiahui Zhao2Ziyi Zhao3Zhihang Li4Yong Li5Yawen Liu6Huan He7NHC Key Laboratory of Radiobiology, School of Public Health, Jilin UniversityNHC Key Laboratory of Radiobiology, School of Public Health, Jilin UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin UniversityNHC Key Laboratory of Radiobiology, School of Public Health, Jilin UniversityAbstract Activating protein 1 (AP-1) is a transcription factor composed of several protein families, Jun proteins and Fos proteins are the components of AP-1. AP-1 is involved in various cellular processes, such as proliferation, differentiation, apoptosis and inflammation. For tumor cells, AP-1 is considered to be a driver whose activity is associated with dysfunction and the onset, development, invasion, and migration of cancer. In addition, AP-1 has been reported to be involved in the drug resistance and radiation resistance of tumor cells during the treatment process. Therefore, AP-1 is a potential target for cancer therapy. At present, a number of inhibitors targeting AP-1 have been developed and have shown certain anti-cancer effects. However, due to the complex structure and function of AP-1, different structures of AP-1 show different effects in different tumor cells, and more studies are needed to reveal its mechanism of action. This article introduces the relationship between AP-1 and tumor development, summarize the current studies and developments of AP-1 related drugs, and provide the future development values of AP-1.https://doi.org/10.1007/s12672-025-01783-1AP-1TumorsTumorigenesisDrug resistanceRadiation resistance |
| spellingShingle | Xinni Xue Zhiwei Li Jiahui Zhao Ziyi Zhao Zhihang Li Yong Li Yawen Liu Huan He Advances in the relationship between AP-1 and tumorigenesis, development and therapy resistance Discover Oncology AP-1 Tumors Tumorigenesis Drug resistance Radiation resistance |
| title | Advances in the relationship between AP-1 and tumorigenesis, development and therapy resistance |
| title_full | Advances in the relationship between AP-1 and tumorigenesis, development and therapy resistance |
| title_fullStr | Advances in the relationship between AP-1 and tumorigenesis, development and therapy resistance |
| title_full_unstemmed | Advances in the relationship between AP-1 and tumorigenesis, development and therapy resistance |
| title_short | Advances in the relationship between AP-1 and tumorigenesis, development and therapy resistance |
| title_sort | advances in the relationship between ap 1 and tumorigenesis development and therapy resistance |
| topic | AP-1 Tumors Tumorigenesis Drug resistance Radiation resistance |
| url | https://doi.org/10.1007/s12672-025-01783-1 |
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