The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate.
Homeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation, but whether post-transcriptional mechanisms can regulate this process is unknown. Here, we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and di...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-12-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002403&type=printable |
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| _version_ | 1849725614321303552 |
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| author | Sandra Blanco Agata Kurowski Jennifer Nichols Fiona M Watt Salvador Aznar Benitah Michaela Frye |
| author_facet | Sandra Blanco Agata Kurowski Jennifer Nichols Fiona M Watt Salvador Aznar Benitah Michaela Frye |
| author_sort | Sandra Blanco |
| collection | DOAJ |
| description | Homeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation, but whether post-transcriptional mechanisms can regulate this process is unknown. Here, we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin. In the epidermis, this methyltransferase is found in a defined sub-population of hair follicle stem cells poised to undergo lineage commitment, and its depletion results in enhanced quiescence and aberrant stem cell differentiation. Our results reveal that post-transcriptional RNA methylation can play a previously unappreciated role in controlling stem cell fate. |
| format | Article |
| id | doaj-art-3f09e8b8c1c54a4dbd5553c1cc99f2f5 |
| institution | DOAJ |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2011-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-3f09e8b8c1c54a4dbd5553c1cc99f2f52025-08-20T03:10:25ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042011-12-01712e100240310.1371/journal.pgen.1002403The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate.Sandra BlancoAgata KurowskiJennifer NicholsFiona M WattSalvador Aznar BenitahMichaela FryeHomeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation, but whether post-transcriptional mechanisms can regulate this process is unknown. Here, we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin. In the epidermis, this methyltransferase is found in a defined sub-population of hair follicle stem cells poised to undergo lineage commitment, and its depletion results in enhanced quiescence and aberrant stem cell differentiation. Our results reveal that post-transcriptional RNA methylation can play a previously unappreciated role in controlling stem cell fate.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002403&type=printable |
| spellingShingle | Sandra Blanco Agata Kurowski Jennifer Nichols Fiona M Watt Salvador Aznar Benitah Michaela Frye The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. PLoS Genetics |
| title | The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. |
| title_full | The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. |
| title_fullStr | The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. |
| title_full_unstemmed | The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. |
| title_short | The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. |
| title_sort | rna methyltransferase misu nsun2 poises epidermal stem cells to differentiate |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002403&type=printable |
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