RhoA/ROCK2 signaling pathway regulates Mn-induced alterations in tight junction proteins leading to cognitive dysfunction in mice

RhoA/ROCK2 signaling pathway regulates Mn-induced alterations in tight junction proteins leading to cognitive dysfunction in mice

Elevated manganese (Mn) exposure has been implicated in a broad spectrum of neurological disorders, including motor dysfunction and cognitive deficits. Previous studies have demonstrated that Mn induces neurotoxicity by disrupting the integrity of the blood–brain barrier (BBB), a critical regulator...

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Bibliographic Details
Main Authors: Yan Ma, Honggang Chen, Yuxin Jiang, Diya Wang, Michael Aschner, Wenjing Luo, Peng Su
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Current Research in Toxicology
Subjects:
Manganese
Tight Junction
RhoA
Gastrodin
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X24000604
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