Over-expression of miR-101 alleviates ventricular remodelingin rat models with acute myocardial infarction by inhibiting JAK2/STAT3 signaling

Over-expression of miR-101 alleviates ventricular remodelingin rat models with acute myocardial infarction by inhibiting JAK2/STAT3 signaling

Objective To explore the effect and underlying molecular mechanism of miR-101 on ventricular remodeling in rats after acute myocardial infarction (AMI). Methods The AMI rat model was established using the left anterior descending coronary artery ligation method. The AMI rats were randomly divided i...

Full description

Saved in:

Bibliographic Details
Main Author:	WU Bo, GUO Hao, ZHONG Zhao, LIU Junfang, WANG Qi, GUO Jibo
Format:	Article
Language:	zho
Published:	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2025-03-01
Series:	Jichu yixue yu linchuang
Subjects:	mir-101\|jak2/stat3 signaling pathway\|acute myocardial infarction\|ventricular remodeling\|myocardial fibrosis
Online Access:	https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-3-281-281.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Baricitinib represses the myocardial fibrosis via blocking JAK/STAT and TGF-β1 pathways in vivo and in vitro
by: Renlei Feng, et al.
Published: (2025-01-01)

JAK/STAT signaling as a key regulator of ferroptosis: mechanisms and therapeutic potentials in cancer and diseases
by: Yimeng Dai, et al.
Published: (2025-03-01)

JAK-STAT inhibitors in noninfectious uveitis – A review
by: Richa Pyare, et al.
Published: (2025-06-01)

JAK-STAT Signaling in Autoimmunity and Cancer
by: Parveen S, et al.
Published: (2025-05-01)

MiR-618 suppresses the proliferation, invasion, and migration of non-small lung cancer via the JAK2/STAT3 axis
by: Ziyuan Chen, et al.
Published: (2024-12-01)

Mechanism of Qingdai in Alleviating Acute Lung Injury by Inhibiting the JAK2/STAT3 Signaling Pathway
by: Qi L, et al.
Published: (2024-12-01)

Left ventricular remodeling in normotensive Wistar rats exposed to intermittent hypoxia of different duration
by: Yu. M. Kolesnyk, et al.
Published: (2023-04-01)

The role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of gout
by: Zeng Zhang, et al.
Published: (2025-03-01)

JAK/STAT signaling in hepatocellular carcinoma
by: Justin Jit Hin Tang, et al.
Published: (2020-03-01)

JAK2, STAT3 Gene Polymorphisms in Turkish Patients with Behçet’s Disease
by: Darya Farhoomand Aksoy, et al.
Published: (2024-01-01)

Left ventricular remodeling in patients with right ventricular myocardial infarction
by: M. T. Beyshenkulov,, et al.
Published: (2015-12-01)

Iron in ventricular remodeling and aneurysms post-myocardial infarction
by: Wang Zuoyan, et al.
Published: (2024-12-01)

Tanshinone I promotes angiogenesis and improves ventricular remodeling post-myocardial infarction via ALDH2 signaling-mediated ferroptosis inhibition
by: Feng Zhang, et al.
Published: (2025-06-01)

Inhibitory effect of doxycycline on mmp2/9 and its improvement in cardiac function and left ventricular remodeling after myocardial infarction in rats
by: Fenli ZHANG, et al.
Published: (2025-05-01)

Arbutin alleviates Mycoplasma gallinarum-induced damage caused by pulmonary fibrosis via the JAK2/STAT3 pathway
by: Ting Liu, et al.
Published: (2024-12-01)

Regulatory T cells: a promising new therapeutic target in ventricular remodeling after myocardial infarction
by: Yiran Qin, et al.
Published: (2025-04-01)

The role of IL‐6/JAK/STAT signal in female infertility caused by hydrosalpinx
by: Jia Deng, et al.
Published: (2023-06-01)

Roles of Autophagy, Mitophagy, and Mitochondria in Left Ventricular Remodeling after Myocardial Infarction
by: Xin Zhang, et al.
Published: (2025-03-01)

Targeting the JAK-STAT pathway in colorectal cancer: mechanisms, clinical implications, and therapeutic potential
by: Penghui Li, et al.
Published: (2024-11-01)

Role of Speckle Tracking in the Evaluation of Left Ventricular Remodeling After Streptokinase Infusion in Patients with Acute Anterior Myocardial Infarction
by: Sh. I. Farag, et al.
Published: (2020-12-01)

The Hyperactivation of JAK-STAT Signaling Connects Inborn Errors of Immunity and Autoimmune Diseases
by: JIANG Yi, et al.
Published: (2024-10-01)

Association between insulin resistance and left ventricular remodeling after STEMI in patients without a history of diabetes mellitus
by: YANG Chendie, et al.
Published: (2025-03-01)

JAK2/STAT3 Signaling in Myeloid Cells Contributes to Obesity-Induced Inflammation and Insulin Resistance
by: Chunyan Zhang, et al.
Published: (2025-08-01)

YWHAG promotes the progression of lung adenocarcinoma through the JAK2/STAT3 pathway
by: Hongmei Zheng, et al.
Published: (2025-03-01)

Early markers of pathological left ventricular remodeling in patients after ST-elevation myocardial infarction according to speckle-tracking echocardiography
by: V. E. Oleinikov, et al.
Published: (2022-07-01)

CDCA4 promotes bladder cancer progression by JAK/STAT signaling pathway
by: Peng Wan, et al.
Published: (2025-01-01)

Convallatoxin inhibits proliferation and angiogenesis of glioma cells via regulating JAK/STAT3 pathway
by: Hao Zhongfei, et al.
Published: (2025-04-01)

Chlamydia trachomatis modulates the expression of JAK-STAT signaling components to attenuate the type II interferon response of epithelial cells
by: Francis L. Fontanilla, et al.
Published: (2024-10-01)

Heart remodeling in patients with acute Q-wave myocardial infarction in the presence of left bundle branch block
by: V. D. Syvolap, et al.
Published: (2018-06-01)

Exploration of JAK/STAT pathway activation in ulcerative colitis reveals sex-dependent activation of JAK2/STAT3 in the inflammatory response
by: Cristina Calviño-Suárez, et al.
Published: (2025-07-01)

Excessive activation of JAK-STAT signaling contributes to inflammation induced by acute Vibrio infection in shrimp
by: Hongliang Zuo, et al.
Published: (2025-12-01)

Glycyrrhiza uralensis Fisch. suppresses cell migration via ROS and JAK/STAT signalling pathways in Drosophila
by: Fangfei Zhou, et al.
Published: (2025-06-01)

Efficient Generation of Megakaryocyte Progenitors and Platelets From HSPCs via JAK2/STAT3 Signaling
by: Huicong Liu, et al.
Published: (2025-06-01)

Keratin 6A promotes skin inflammation through JAK1-STAT3 activation in keratinocytes
by: Mengting Chen, et al.
Published: (2025-05-01)

Synergistic effects of anlotinib and DDP on breast cancer: targeting the VEGF/JAK2/STAT3 axis
by: Hongmei Zhang, et al.
Published: (2024-10-01)

Lyophilized MSC-EVs attenuates COVID-19 pathogenesis by regulating the JAK/STAT pathway
by: Nesrine Ebrahim, et al.
Published: (2025-05-01)

JAK inhibitors: a new choice for diabetes mellitus?
by: Mengjun Zhou, et al.
Published: (2025-01-01)

Effects of Sodium Cantharidinate on Proliferation and Apoptosis of Gastric Cancer Cells by Inhibiting JAK2/STAT3 Pathway
by: Xinghong LIU, et al.
Published: (2024-11-01)

Effects of SGLT2 inhibitors on cardiac autonomic activity and ventricular remodeling in patients with acute myocardial infarction: study protocol for a clinical trial
by: Jun Wan, et al.
Published: (2025-07-01)

Vitamin A family suppresses periodontitis by restoring mitochondrial metabolic reprogramming in macrophages through JAK-STAT pathway
by: Zishuo Cheng, et al.
Published: (2025-01-01)