Green biosynthesis of bimetallic silver titanium dioxide nanoparticles using Pluchea indica with their anticancer, antimicrobial, and antioxidant activities

Green biosynthesis of bimetallic silver titanium dioxide nanoparticles using Pluchea indica with their anticancer, antimicrobial, and antioxidant activities

Abstract Natural plant extracts provide a cost-effective and eco-friendly option for the synthesis of bimetallic nanoparticles, as opposed to traditional chemical or physical methods. This research involved the bio-fabrication of silver-titanium dioxide bimetallic nanoparticles (Ag-TiO2 BNPs) utiliz...

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Main Authors: Samy Selim, Bahaa M. Badr, Mohamed H. Moustafa, Ebrahim Saied, Fathy M. Elkady, Ayman salama, Abeer S. Aloufi, Noura A. Algamdi, Noura N. Alzahofi, Emad Abada, Mohammed S. Alshammari, Soad K. Al Jaouni, Amr H. Hashem
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Biosynthesis
Bimetallic nanoparticles
Anticancer activity
Antimicrobial activity
Online Access:https://doi.org/10.1038/s41598-025-10349-8
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Summary:Abstract Natural plant extracts provide a cost-effective and eco-friendly option for the synthesis of bimetallic nanoparticles, as opposed to traditional chemical or physical methods. This research involved the bio-fabrication of silver-titanium dioxide bimetallic nanoparticles (Ag-TiO2 BNPs) utilizing the leaf extract of Pluchea indica. The Ag-TiO2 BNPs underwent characterization through UV-vis spectroscopy, FTIR, TEM, XRD, and DLS techniques. The UV-Vis spectroscopy results revealed an absorbance peak at 350 nm, which confirms the successful synthesis of Ag-TiO2 BNPs. TEM observations revealed that the average diameter of the Ag-TiO2 BNPs varied between 10 and 60 nm. The assessment of the anticancer, antibacterial, and antioxidant bioactivities of the biosynthesized Ag-TiO2 BNPs was conducted. Results revealed that the IC50 of Ag-TiO2 BNP against Wi-38 normal cell line was 169.6 µg/mL. Moreover, Ag-TiO2 BNPs exhibited anticancer activity against MCF-7 cancerous cell line with an IC50 of 33.5 µg/mL. Furthermore, the produced Ag-TiO2 BNPs exhibited antibacterial properties against a range of pathogenic bacterial strains, with MIC varying from 31.25 to 62.5 µg/mL. Additionally, Ag-TiO2 BNPs showed antioxidant activity with IC50 225 µg/mL. In conclusion, Ag-TiO2 BNPs was successfully biosynthesized using P. indica leaves, where it had anticancer, antibacterial, and antioxidant properties.
ISSN:2045-2322

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