Small extracellular vesicles from human umbilical cord mesenchymal stem cells delivering miR-202-5p alleviate renal ischemia-reperfusion injury by targeting the GOLIM4/PI3K/AKT axis

Small extracellular vesicles from human umbilical cord mesenchymal stem cells delivering miR-202-5p alleviate renal ischemia-reperfusion injury by targeting the GOLIM4/PI3K/AKT axis

BackgroundIschemia–reperfusion injury (IRI) is a leading contributor to acute kidney injury (AKI), resulting in severe renal dysfunction and increased mortality. Despite progress in medical research, effective therapies for IRI remain limited. Recently, small extracellular vesicles (sEVs) originatin...

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Bibliographic Details
Main Authors: Xiang Peng, Wei Shi, Haitao Yu, Zhenwei Feng, Zongjie Wei, Weiyang He, Xin Gou, Yongpeng Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
renal ischemia reperfusion injury
acute kidney injury
human umbilical cord mesenchymal stem cells
small extracellular vesicles
miR-202-5p
GOLIM4
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1586174/full
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