Dexmedetomidine versus Midazolam in Procedural Sedation. A Systematic Review of Efficacy and Safety.
<h4>Objectives</h4>To systematically review the literature comparing the efficacy and safety of dexmedetomidine and midazolam when used for procedural sedation.<h4>Materials and methods</h4>We searched MEDLINE, EMBASE and COCHRANE for clinical trials comparing dexmedetomidine...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0169525&type=printable |
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| author | Clemens R M Barends Anthony Absalom Baucke van Minnen Arjan Vissink Anita Visser |
| author_facet | Clemens R M Barends Anthony Absalom Baucke van Minnen Arjan Vissink Anita Visser |
| author_sort | Clemens R M Barends |
| collection | DOAJ |
| description | <h4>Objectives</h4>To systematically review the literature comparing the efficacy and safety of dexmedetomidine and midazolam when used for procedural sedation.<h4>Materials and methods</h4>We searched MEDLINE, EMBASE and COCHRANE for clinical trials comparing dexmedetomidine and midazolam for procedural sedation up to June 20, 2016. Inclusion criteria: clinical trial, human subjects, adult subjects (≥18 years), article written in English, German, French or Dutch, use of study medication for conscious sedation and at least one group receiving dexmedetomidine and one group receiving midazolam. Exclusion criteria: patients in intensive care, pediatric subjects and per protocol use of additional sedative medication other than rescue medication. Outcome measures for efficacy comparison were patient and clinician satisfaction scores and pain scores; outcome measures for safety comparison were hypotension, hypoxia, and circulatory and respiratory complications.<h4>Results</h4>We identified 89 papers, of which 12 satisfied the inclusion and exclusion criteria; 883 patients were included in these studies. Dexmedetomidine was associated with higher patient and operator satisfaction than midazolam. Patients receiving dexmedetomidine experienced less pain and had lower analgesic requirements. Respiratory and hemodynamic safety were similar.<h4>Conclusions</h4>Dexmedetomidine is a promising alternative to midazolam for use in procedural sedation. Dexmedetomidine provides more comfort during the procedure for the patient and clinician. If carefully titrated, the safety profiles are similar. |
| format | Article |
| id | doaj-art-3ef73d95eaac41e7b6125f1a9ee0edff |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-3ef73d95eaac41e7b6125f1a9ee0edff2025-08-20T02:20:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01121e016952510.1371/journal.pone.0169525Dexmedetomidine versus Midazolam in Procedural Sedation. A Systematic Review of Efficacy and Safety.Clemens R M BarendsAnthony AbsalomBaucke van MinnenArjan VissinkAnita Visser<h4>Objectives</h4>To systematically review the literature comparing the efficacy and safety of dexmedetomidine and midazolam when used for procedural sedation.<h4>Materials and methods</h4>We searched MEDLINE, EMBASE and COCHRANE for clinical trials comparing dexmedetomidine and midazolam for procedural sedation up to June 20, 2016. Inclusion criteria: clinical trial, human subjects, adult subjects (≥18 years), article written in English, German, French or Dutch, use of study medication for conscious sedation and at least one group receiving dexmedetomidine and one group receiving midazolam. Exclusion criteria: patients in intensive care, pediatric subjects and per protocol use of additional sedative medication other than rescue medication. Outcome measures for efficacy comparison were patient and clinician satisfaction scores and pain scores; outcome measures for safety comparison were hypotension, hypoxia, and circulatory and respiratory complications.<h4>Results</h4>We identified 89 papers, of which 12 satisfied the inclusion and exclusion criteria; 883 patients were included in these studies. Dexmedetomidine was associated with higher patient and operator satisfaction than midazolam. Patients receiving dexmedetomidine experienced less pain and had lower analgesic requirements. Respiratory and hemodynamic safety were similar.<h4>Conclusions</h4>Dexmedetomidine is a promising alternative to midazolam for use in procedural sedation. Dexmedetomidine provides more comfort during the procedure for the patient and clinician. If carefully titrated, the safety profiles are similar.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0169525&type=printable |
| spellingShingle | Clemens R M Barends Anthony Absalom Baucke van Minnen Arjan Vissink Anita Visser Dexmedetomidine versus Midazolam in Procedural Sedation. A Systematic Review of Efficacy and Safety. PLoS ONE |
| title | Dexmedetomidine versus Midazolam in Procedural Sedation. A Systematic Review of Efficacy and Safety. |
| title_full | Dexmedetomidine versus Midazolam in Procedural Sedation. A Systematic Review of Efficacy and Safety. |
| title_fullStr | Dexmedetomidine versus Midazolam in Procedural Sedation. A Systematic Review of Efficacy and Safety. |
| title_full_unstemmed | Dexmedetomidine versus Midazolam in Procedural Sedation. A Systematic Review of Efficacy and Safety. |
| title_short | Dexmedetomidine versus Midazolam in Procedural Sedation. A Systematic Review of Efficacy and Safety. |
| title_sort | dexmedetomidine versus midazolam in procedural sedation a systematic review of efficacy and safety |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0169525&type=printable |
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