Body mass index, exercise capacity and functional status in chronic heart failure
Abstract Aims This short communication aims to assess the associations of body mass index (BMI) with key functional parameters, including exercise tolerance and functional status, among individuals with chronic heart failure. Methods and results From four chronic heart failure studies ( HF-ACTION [H...
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2025-07-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04998-w |
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| author | Steve R. Noumegni Arnaud D. Kaze Gregg C. Fonarow Justin B. Echouffo-Tcheugui |
| author_facet | Steve R. Noumegni Arnaud D. Kaze Gregg C. Fonarow Justin B. Echouffo-Tcheugui |
| author_sort | Steve R. Noumegni |
| collection | DOAJ |
| description | Abstract Aims This short communication aims to assess the associations of body mass index (BMI) with key functional parameters, including exercise tolerance and functional status, among individuals with chronic heart failure. Methods and results From four chronic heart failure studies ( HF-ACTION [Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training], NEAT-HFpEF [Nitrate’s Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction (HFpEF)], INDIE-HFpEF [Inorganic Nitrite Delivery to Improve Exercise Capacity in HFpEF], and RELAX-HFpEF [Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Heart Failure with Preserved Ejection Fraction]), we studied 2,546 participants (mean age: 60.2 ± 12.8 years, 67.8% men, 43.7% non-Whites individuals, 83% with heart failure with reduced ejection fraction (HFrEF), 17% with heart failure with preserved ejection fraction [HFpEF]). Among them, 52.8% had obesity [n = 1344], 29.8% were overweight [n = 758], and 17.4% had a normal body mass index [n = 444]). One-unit increment in BMI (kg/m2) was associated with a lower 6MWT-D (β: -2.78, 95% CI: -3.54, -2.02), a lower VO2max (β: -0.18, 95% CI: -0.21, -0.15), a lower VO2AT (β: -0.10, 95% CI: -0.12, -0.08), a lower RERpeak (β: -0.003, 95% CI: -0.004, -0.002), a lower QoL (β for ln [KCCQ score]: -0.005, 95% CI: -0.008, -0.002), but not with HRpeak (β: β: -0.04, 95% CI: -0.20, 0.11). After adjustment for confounders, individuals with obesity (BMI ≥ 30 kg/m2) compared to those with a normal BMI had lower 6MWT-D (beta coefficient [β]: -21.02, 95% CI: -34.27, -7.77), VO2max (β: -1.90, 95% CI: -2.42, -1.38), VO2AT (β: -1.16, 95% CI: -1.53, -0.80), RERpeak (β: -0.03, 95% CI: -0.05, -0.02), and QoL (β for ln [KCCQ score]: -0.05, 95% CI: -0.10, -0.0006) levels. However, the obesity and normal BMI groups were not significantly different in terms of HRpeak (β: 1.07, 95% CI: -1.71, 3.85). Conclusions Our study found that in patients with chronic heart failure, increasing body mass index is associated with poor exercise capacity and functional status. Our findings underscore the potential importance of optimizing weight management among individuals with chronic heart failure to improve functional status. |
| format | Article |
| id | doaj-art-3ef55ecba3e346aa9fcfa189883d38f3 |
| institution | DOAJ |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-3ef55ecba3e346aa9fcfa189883d38f32025-08-20T03:04:16ZengBMCBMC Cardiovascular Disorders1471-22612025-07-012511510.1186/s12872-025-04998-wBody mass index, exercise capacity and functional status in chronic heart failureSteve R. Noumegni0Arnaud D. Kaze1Gregg C. Fonarow2Justin B. Echouffo-Tcheugui3Department of Medicine, University of Maryland Midtown CampusDivision of Cardiology, Banner - University Medical Center Phoenix, The University of Arizona College of MedicineAhmanson-UCLA Cardiomyopathy Center, Ronald Reagan UCLA Medical CenterDepartment of Medicine, Johns Hopkins UniversityAbstract Aims This short communication aims to assess the associations of body mass index (BMI) with key functional parameters, including exercise tolerance and functional status, among individuals with chronic heart failure. Methods and results From four chronic heart failure studies ( HF-ACTION [Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training], NEAT-HFpEF [Nitrate’s Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction (HFpEF)], INDIE-HFpEF [Inorganic Nitrite Delivery to Improve Exercise Capacity in HFpEF], and RELAX-HFpEF [Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Heart Failure with Preserved Ejection Fraction]), we studied 2,546 participants (mean age: 60.2 ± 12.8 years, 67.8% men, 43.7% non-Whites individuals, 83% with heart failure with reduced ejection fraction (HFrEF), 17% with heart failure with preserved ejection fraction [HFpEF]). Among them, 52.8% had obesity [n = 1344], 29.8% were overweight [n = 758], and 17.4% had a normal body mass index [n = 444]). One-unit increment in BMI (kg/m2) was associated with a lower 6MWT-D (β: -2.78, 95% CI: -3.54, -2.02), a lower VO2max (β: -0.18, 95% CI: -0.21, -0.15), a lower VO2AT (β: -0.10, 95% CI: -0.12, -0.08), a lower RERpeak (β: -0.003, 95% CI: -0.004, -0.002), a lower QoL (β for ln [KCCQ score]: -0.005, 95% CI: -0.008, -0.002), but not with HRpeak (β: β: -0.04, 95% CI: -0.20, 0.11). After adjustment for confounders, individuals with obesity (BMI ≥ 30 kg/m2) compared to those with a normal BMI had lower 6MWT-D (beta coefficient [β]: -21.02, 95% CI: -34.27, -7.77), VO2max (β: -1.90, 95% CI: -2.42, -1.38), VO2AT (β: -1.16, 95% CI: -1.53, -0.80), RERpeak (β: -0.03, 95% CI: -0.05, -0.02), and QoL (β for ln [KCCQ score]: -0.05, 95% CI: -0.10, -0.0006) levels. However, the obesity and normal BMI groups were not significantly different in terms of HRpeak (β: 1.07, 95% CI: -1.71, 3.85). Conclusions Our study found that in patients with chronic heart failure, increasing body mass index is associated with poor exercise capacity and functional status. Our findings underscore the potential importance of optimizing weight management among individuals with chronic heart failure to improve functional status.https://doi.org/10.1186/s12872-025-04998-wObesityHeart failureExercise capacityQuality of lifeOutcomes |
| spellingShingle | Steve R. Noumegni Arnaud D. Kaze Gregg C. Fonarow Justin B. Echouffo-Tcheugui Body mass index, exercise capacity and functional status in chronic heart failure BMC Cardiovascular Disorders Obesity Heart failure Exercise capacity Quality of life Outcomes |
| title | Body mass index, exercise capacity and functional status in chronic heart failure |
| title_full | Body mass index, exercise capacity and functional status in chronic heart failure |
| title_fullStr | Body mass index, exercise capacity and functional status in chronic heart failure |
| title_full_unstemmed | Body mass index, exercise capacity and functional status in chronic heart failure |
| title_short | Body mass index, exercise capacity and functional status in chronic heart failure |
| title_sort | body mass index exercise capacity and functional status in chronic heart failure |
| topic | Obesity Heart failure Exercise capacity Quality of life Outcomes |
| url | https://doi.org/10.1186/s12872-025-04998-w |
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