Hexosamine biosynthesis disruption impairs GPI production and arrests Plasmodium falciparum growth at schizont stages.

Hexosamine biosynthesis disruption impairs GPI production and arrests Plasmodium falciparum growth at schizont stages.

UDP-N-acetylglucosamine (UDP-GlcNAc) is a crucial sugar nucleotide for glycan synthesis in eukaryotes. In the malaria parasite Plasmodium falciparum, UDP-GlcNAc is synthesized via the hexosamine biosynthetic pathway (HBP) and is essential for glycosylphosphatidylinositol (GPI) anchor production, the...

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Main Authors: María Pía Alberione, Yunuen Avalos-Padilla, Gabriel W Rangel, Miriam Ramírez, Tais Romero-Uruñuela, Àngel Fenollar, Jonathan Ortega-Barrionuevo, Marcell Crispim, Terry K Smith, Manuel Llinás, Luis Izquierdo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012832
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