Comparative Analysis of Time to All-cause Treatment Discontinuation and Rehospitalization among Early-phase Schizophrenia Patients Discharged on Long-acting Injectable Antipsychotics versus Oral Antipsychotics
Objectives: The early phase of schizophrenia is crucial in determining the long-term prognosis for patients with schizophrenia. In this study, we intended to compare time to all-cause discontinuation and rehospitalization within one year for early-phase schizophrenia patients discharged on long-acti...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
|
| Series: | Taiwanese Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/tpsy.tpsy_9_25 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850200972858490880 |
|---|---|
| author | Ta-Chun Lin Ching-Hua Lin Huei-Ping Chiu |
| author_facet | Ta-Chun Lin Ching-Hua Lin Huei-Ping Chiu |
| author_sort | Ta-Chun Lin |
| collection | DOAJ |
| description | Objectives:
The early phase of schizophrenia is crucial in determining the long-term prognosis for patients with schizophrenia. In this study, we intended to compare time to all-cause discontinuation and rehospitalization within one year for early-phase schizophrenia patients discharged on long-acting injectable antipsychotics (LAIs) versus oral antipsychotics (OAPs).
Methods:
We analyzed data of early-phase schizophrenia patients, defined as having a duration of illness of at least six months and no more than seven years, discharged on either LAIs or OAPs from a psychiatric hospital in southern Taiwan between 2006 and 2021. Survival analysis was used to compare the time to all-cause discontinuation and rehospitalization within one year of discharge between LAIs and OAPs. With the temporal trend test and Cochran–Armitage trend test, we analyzed patients using LAIs, at discharge within the study period.
Results:
We included 2,301 patients for analysis. The LAIs group (n = 355) had a significantly longer time to all-cause discontinuation (p < 0.05) and a significantly longer time to rehospitalization (p < 0.01) than the OAPs group (n = 1,946). Patients with LAI use at discharge significantly demonstrated a significant increase from the first period to the last period (Z = 6.555, p < 0.001). Among patients discharged on LAIs, the prescription rate of second-generation antipsychotic LAIs was significantly increased over time (Z = 10.430, p < 0.001).
Conclusion:
For early-phase schizophrenia, LAIs were superior to OAPs in lengthening the time to all-cause discontinuation and rehospitalization. LAIs may be considered to prescribe initially, rather than being reserved solely for patients experiencing multiple relapses or displaying nonadherence to OAPs. |
| format | Article |
| id | doaj-art-3ef17cb0c82c444081fe7a87f6f06536 |
| institution | OA Journals |
| issn | 1028-3684 2666-2078 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Taiwanese Journal of Psychiatry |
| spelling | doaj-art-3ef17cb0c82c444081fe7a87f6f065362025-08-20T02:12:10ZengWolters Kluwer Medknow PublicationsTaiwanese Journal of Psychiatry1028-36842666-20782025-01-01391354110.4103/tpsy.tpsy_9_25Comparative Analysis of Time to All-cause Treatment Discontinuation and Rehospitalization among Early-phase Schizophrenia Patients Discharged on Long-acting Injectable Antipsychotics versus Oral AntipsychoticsTa-Chun LinChing-Hua LinHuei-Ping ChiuObjectives: The early phase of schizophrenia is crucial in determining the long-term prognosis for patients with schizophrenia. In this study, we intended to compare time to all-cause discontinuation and rehospitalization within one year for early-phase schizophrenia patients discharged on long-acting injectable antipsychotics (LAIs) versus oral antipsychotics (OAPs). Methods: We analyzed data of early-phase schizophrenia patients, defined as having a duration of illness of at least six months and no more than seven years, discharged on either LAIs or OAPs from a psychiatric hospital in southern Taiwan between 2006 and 2021. Survival analysis was used to compare the time to all-cause discontinuation and rehospitalization within one year of discharge between LAIs and OAPs. With the temporal trend test and Cochran–Armitage trend test, we analyzed patients using LAIs, at discharge within the study period. Results: We included 2,301 patients for analysis. The LAIs group (n = 355) had a significantly longer time to all-cause discontinuation (p < 0.05) and a significantly longer time to rehospitalization (p < 0.01) than the OAPs group (n = 1,946). Patients with LAI use at discharge significantly demonstrated a significant increase from the first period to the last period (Z = 6.555, p < 0.001). Among patients discharged on LAIs, the prescription rate of second-generation antipsychotic LAIs was significantly increased over time (Z = 10.430, p < 0.001). Conclusion: For early-phase schizophrenia, LAIs were superior to OAPs in lengthening the time to all-cause discontinuation and rehospitalization. LAIs may be considered to prescribe initially, rather than being reserved solely for patients experiencing multiple relapses or displaying nonadherence to OAPs.https://journals.lww.com/10.4103/tpsy.tpsy_9_25antipsychotic adherencefirst-generation antipsychoticssecond-generation antipsychoticsrelapse prevention |
| spellingShingle | Ta-Chun Lin Ching-Hua Lin Huei-Ping Chiu Comparative Analysis of Time to All-cause Treatment Discontinuation and Rehospitalization among Early-phase Schizophrenia Patients Discharged on Long-acting Injectable Antipsychotics versus Oral Antipsychotics Taiwanese Journal of Psychiatry antipsychotic adherence first-generation antipsychotics second-generation antipsychotics relapse prevention |
| title | Comparative Analysis of Time to All-cause Treatment Discontinuation and Rehospitalization among Early-phase Schizophrenia Patients Discharged on Long-acting Injectable Antipsychotics versus Oral Antipsychotics |
| title_full | Comparative Analysis of Time to All-cause Treatment Discontinuation and Rehospitalization among Early-phase Schizophrenia Patients Discharged on Long-acting Injectable Antipsychotics versus Oral Antipsychotics |
| title_fullStr | Comparative Analysis of Time to All-cause Treatment Discontinuation and Rehospitalization among Early-phase Schizophrenia Patients Discharged on Long-acting Injectable Antipsychotics versus Oral Antipsychotics |
| title_full_unstemmed | Comparative Analysis of Time to All-cause Treatment Discontinuation and Rehospitalization among Early-phase Schizophrenia Patients Discharged on Long-acting Injectable Antipsychotics versus Oral Antipsychotics |
| title_short | Comparative Analysis of Time to All-cause Treatment Discontinuation and Rehospitalization among Early-phase Schizophrenia Patients Discharged on Long-acting Injectable Antipsychotics versus Oral Antipsychotics |
| title_sort | comparative analysis of time to all cause treatment discontinuation and rehospitalization among early phase schizophrenia patients discharged on long acting injectable antipsychotics versus oral antipsychotics |
| topic | antipsychotic adherence first-generation antipsychotics second-generation antipsychotics relapse prevention |
| url | https://journals.lww.com/10.4103/tpsy.tpsy_9_25 |
| work_keys_str_mv | AT tachunlin comparativeanalysisoftimetoallcausetreatmentdiscontinuationandrehospitalizationamongearlyphaseschizophreniapatientsdischargedonlongactinginjectableantipsychoticsversusoralantipsychotics AT chinghualin comparativeanalysisoftimetoallcausetreatmentdiscontinuationandrehospitalizationamongearlyphaseschizophreniapatientsdischargedonlongactinginjectableantipsychoticsversusoralantipsychotics AT hueipingchiu comparativeanalysisoftimetoallcausetreatmentdiscontinuationandrehospitalizationamongearlyphaseschizophreniapatientsdischargedonlongactinginjectableantipsychoticsversusoralantipsychotics |