Cutaneous Scrotal Metastasis Secondary to Primary Prostate Adenocarcinoma Responding to Immunotherapy
This case demonstrates the aggressive progression of prostate adenocarcinoma, failing 3 treatment regimens. Although the patient initially responded to treatments, he developed cutaneous metastasis. Genomic tumor analysis of scrotal tissue confirmed targetable molecular mutations. Treatment with sys...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2022-12-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0682 |
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| _version_ | 1850202443719114752 |
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| author | Celine A. Fadel Andre M. Kallab |
| author_facet | Celine A. Fadel Andre M. Kallab |
| author_sort | Celine A. Fadel |
| collection | DOAJ |
| description | This case demonstrates the aggressive progression of prostate adenocarcinoma, failing 3 treatment regimens. Although the patient initially responded to treatments, he developed cutaneous metastasis. Genomic tumor analysis of scrotal tissue confirmed targetable molecular mutations. Treatment with systemic immunotherapy was initiated with complete resolution of disease. This case reveals the rare metastasis of prostate adenocarcinoma to the scrotum with advanced refractory cancer and the successful response to immunotherapy. It illustrates the importance of tumor genomic testing in advanced refractory prostate cancer. |
| format | Article |
| id | doaj-art-3eecec1025914e2ca74f8bc0d998ea3b |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-3eecec1025914e2ca74f8bc0d998ea3b2025-08-20T02:11:46ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642022-12-0111010.7326/aimcc.2022.0682Cutaneous Scrotal Metastasis Secondary to Primary Prostate Adenocarcinoma Responding to ImmunotherapyCeline A. Fadel0Andre M. Kallab11Internal Medicine Residency: Northeast Georgia Medical Center, Gainesville, Georgia2Department of Hematology-Oncology: Northeast Georgia Diagnostic Clinic, Gainesville, GeorgiaThis case demonstrates the aggressive progression of prostate adenocarcinoma, failing 3 treatment regimens. Although the patient initially responded to treatments, he developed cutaneous metastasis. Genomic tumor analysis of scrotal tissue confirmed targetable molecular mutations. Treatment with systemic immunotherapy was initiated with complete resolution of disease. This case reveals the rare metastasis of prostate adenocarcinoma to the scrotum with advanced refractory cancer and the successful response to immunotherapy. It illustrates the importance of tumor genomic testing in advanced refractory prostate cancer.https://www.acpjournals.org/doi/10.7326/aimcc.2022.0682 |
| spellingShingle | Celine A. Fadel Andre M. Kallab Cutaneous Scrotal Metastasis Secondary to Primary Prostate Adenocarcinoma Responding to Immunotherapy Annals of Internal Medicine: Clinical Cases |
| title | Cutaneous Scrotal Metastasis Secondary to Primary Prostate Adenocarcinoma Responding to Immunotherapy |
| title_full | Cutaneous Scrotal Metastasis Secondary to Primary Prostate Adenocarcinoma Responding to Immunotherapy |
| title_fullStr | Cutaneous Scrotal Metastasis Secondary to Primary Prostate Adenocarcinoma Responding to Immunotherapy |
| title_full_unstemmed | Cutaneous Scrotal Metastasis Secondary to Primary Prostate Adenocarcinoma Responding to Immunotherapy |
| title_short | Cutaneous Scrotal Metastasis Secondary to Primary Prostate Adenocarcinoma Responding to Immunotherapy |
| title_sort | cutaneous scrotal metastasis secondary to primary prostate adenocarcinoma responding to immunotherapy |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0682 |
| work_keys_str_mv | AT celineafadel cutaneousscrotalmetastasissecondarytoprimaryprostateadenocarcinomarespondingtoimmunotherapy AT andremkallab cutaneousscrotalmetastasissecondarytoprimaryprostateadenocarcinomarespondingtoimmunotherapy |